Mutagenic potential of anti-herpes agents

• Published in: Life sciences (1973) Vol. 38; no. 3; p. 281
• Main Authors: De Clercq, E, Cassiman, J J
• Format: Journal Article
• Language: English
• Published: Netherlands 20.01.1986
• Subjects: Acyclovir - pharmacology; Antiviral Agents - pharmacology; Cytosine - analogs & derivatives; Cytosine - pharmacology; Guanine - analogs & derivatives; Guanine - pharmacology; Herpes Simplex - drug therapy; Humans; Lymphocytes - drug effects; Lymphocytes - ultrastructure; Mutagenicity Tests; Sister Chromatid Exchange - drug effects; Uridine - analogs & derivatives; Uridine - pharmacology

A number of anti-herpes agents which are either licensed for clinical use (acyclovir) or subject of clinical studies (bromovinyldeoxyuridine, fluoroiodoaracytidine, dihydroxypropoxymethylguanine) or under preclinical investigation (i.e., fluoroiodoarauridine), fluoromethylarauridine, dihydroxybutylg...