Association between high polygenic risk scores and long-term exposure to air pollution in asthma development: a hospital-based case-control study

• Published in: Environmental health Vol. 24; no. 1; pp. 49 - 11
• Main Authors: Chen, I-Chieh, Chen, Yi-Ming, Chen, Yun-Wen, Hsiao, Tzu-Hung, Yang, Hui-Wen, Tang, Kuo-Tung, Lin, Ching-Heng, Chu, Yu-Wen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.07.2025; BioMed Central; BMC
• Subjects: Adult; Aged; Air Pollutants - adverse effects; Air Pollutants - analysis; Air pollution; Air Pollution - adverse effects; Air pollution effects; Allergic diseases; Asthma; Asthma - chemically induced; Asthma - epidemiology; Asthma - genetics; Biobanks; Case studies; Case-Control Studies; Chronic obstructive pulmonary disease; Dermatitis; Electronic health records; Environmental aspects; Environmental Exposure - adverse effects; Epidemiology; Exposure; Female; Genetic aspects; Genetic Risk Score; Genomes; Health aspects; Health care facilities; Health risk assessment; Health risks; Hospitals; Humans; Incidence; Inflammation; Long-term exposure; Low concentrations; Male; Medical records; Middle Aged; Multifactorial Inheritance; Multifactorial traits; Nitrogen dioxide; Particulate Matter; Patients; Pollutants; Polygenic risk score; Precision medicine; Quality control; Quartiles; Retrospective Studies; Rhinitis; Risk; Risk Factors; Scandals; Taiwan - epidemiology; Taiwan; United Kingdom > UK; Polygenic risk score; Long-term exposure; Air pollution; Asthma

Air pollution is widely associated with allergic diseases, including asthma. Although previous studies have suggested an epidemiological link between air pollution and asthma, the combined effects of air pollutants and polygenic risk scores (PRSs) on asthma risk remain incompletely understood. This...