The analgesic and respiratory depressant actions of metorphamide in mice and rabbits
Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. MET induced-analgesia was naloxone reversible and potentiated by bestatin. Naloxonazine, a relatively selective mu 1 blocker, at certain dosage (50 μg per rabbit, icv), could abolish the an...
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| Published in | Neuropeptides (Edinburgh) Vol. 6; no. 2; pp. 121 - 131 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
01.01.1985
Elsevier |
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| Abstract | Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. MET induced-analgesia was naloxone reversible and potentiated by bestatin. Naloxonazine, a relatively selective mu 1 blocker, at certain dosage (50 μg per rabbit, icv), could abolish the analgesia but not the respiratory inhibition produced by MET. Our result indicates that mu 1 receptors mediate the MET induced-analgesia but not its respiratory effect. Since MET is a mu- and kappa-ligand with very low delta activity, the MET induced respiratory depression may be mediated by mu 2 or kappa binding sites. |
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| AbstractList | Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. Results indicates that mu 1 receptors mediate the MET induced-analgesia but not its respiratory effect. Since MEt is a mu- and kappa-ligand with very low delta activity, the MET induced respiratory depression may be mediated by mu 2 or kappa binding sites. Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. MET induced-analgesia was naloxone reversible and potentiated by bestatin. Naloxonazine, a relatively selective mu 1 blocker, at certain dosage (50 micrograms per rabbit, icv), could abolish the analgesia but not the respiratory inhibition produced by MET. Our result indicates that mu 1 receptors mediate the MET induced-analgesia but not its respiratory effect. Since MET is a mu- and kappa-ligand with very low delta activity, the MET induced respiratory depression may be mediated by mu 2 or kappa binding sites. Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. MET induced-analgesia was naloxone reversible and potentiated by bestatin. Naloxonazine, a relatively selective mu 1 blocker, at certain dosage (50 μg per rabbit, icv), could abolish the analgesia but not the respiratory inhibition produced by MET. Our result indicates that mu 1 receptors mediate the MET induced-analgesia but not its respiratory effect. Since MET is a mu- and kappa-ligand with very low delta activity, the MET induced respiratory depression may be mediated by mu 2 or kappa binding sites. |
| Author | Zhang, AnZhong Weber, E. Xu, ShaoFen He, XiaoPin Niu, ShanFu Zhou, KaiRong Chang, J.K. Xu, WeiMin Lu, WenXiao |
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| Cites_doi | 10.1016/0014-2999(80)90518-X 10.1021/jo01136a022 10.1016/0024-3205(80)90470-1 10.1016/0006-8993(77)90699-0 10.1126/science.6256856 10.1152/ajplegacy.1962.203.5.763 10.3727/036012980816952587 10.1016/0024-3205(82)90387-3 10.1038/305721a0 |
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| References_xml | – volume: 5 start-page: 131 year: 1980 end-page: 146 ident: BIB10 article-title: Endorphin and acupuncture analgesia research in the people's republic of china publication-title: Acupuncture & Electro-Therapeutics Res. Int. J. contributor: fullname: Zhang – volume: 203 start-page: 763 year: 1962 end-page: 774 ident: BIB7 article-title: Perfusion of the cerebral ventricular system in unaneathetized goats publication-title: Am. J. 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| Snippet | Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. MET induced-analgesia was naloxone reversible... Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. Results indicates that mu 1 receptors mediate... |
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| SubjectTerms | Analgesics Animals Biological and medical sciences Depression, Chemical Enkephalin, Methionine - analogs & derivatives Enkephalin, Methionine - antagonists & inhibitors Enkephalin, Methionine - pharmacology Female Injections, Intraventricular Male Medical sciences Mice Naloxone - analogs & derivatives Naloxone - pharmacology Neuropharmacology Pharmacology. Drug treatments Rabbits Respiration - drug effects Sensory Thresholds |
| Title | The analgesic and respiratory depressant actions of metorphamide in mice and rabbits |
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