LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36

• Published in: Pharmacological research Vol. 211; p. 107567
• Main Authors: Leng, Yingrong, Zhang, Yanqiu, Cheng, Yang, Ye, Shengtao, Zheng, Ying, He, Mengmeng, Wu, Enyi, Kong, Lingyi, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2025; Elsevier
• Subjects: Adipose expansion; Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; CD36 Antigens - genetics; CD36 Antigens - metabolism; Disease Progression; Hepatocellular carcinoma; Humans; Lipid Metabolism; Liver - metabolism; Liver - pathology; Liver microenvironment; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; MASH; MASLD; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; PARylation; Poly (ADP-Ribose) Polymerase-1 - genetics; Poly (ADP-Ribose) Polymerase-1 - metabolism; RNA decay; Tumor Microenvironment; RNA decay; Hepatocellular carcinoma; MASH; Liver microenvironment; MASLD; Adipose expansion; PARylation

Limb expression 1-like protein (LIX1L) is an essential player in liver disorders, but its function in metabolic dysfunction-associated steatohepatitis (MASH) and associated hepatocellular carcinoma (HCC) progression remains obscure. Here, we identify LIX1L as a key integrative regulator linking lipi...