A hypoxic injury potential in the hippocampal slice

In rat hippocampal slices, neurons in the stratum pyramidale of the CA1 were stimulated orthodromically and antidromically while the resultant extracellular population spikes were monitored. Hypoxic conditions were then induced. After disappearance of the orthodromic population spike, a second ortho...

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Bibliographic Details
Published inBrain research Vol. 453; no. 1-2; p. 357
Main Authors Fairchild, M D, Parsons, J E, Wasterlain, C G, Rinaldi, P C, Wallis, R A
Format Journal Article
LanguageEnglish
Published Netherlands 21.06.1988
Subjects
Action Potentials
Animals
Electric Stimulation
Hippocampus - physiopathology
Hypoxia - physiopathology
In Vitro Techniques
Rats
Time Factors
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Summary:In rat hippocampal slices, neurons in the stratum pyramidale of the CA1 were stimulated orthodromically and antidromically while the resultant extracellular population spikes were monitored. Hypoxic conditions were then induced. After disappearance of the orthodromic population spike, a second orthodromic population spike appeared. We have titled this the hypoxic injury potential since it reflects the onset of permanent injury to neurons in area CA1 of the hippocampus.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(88)90178-3