Fomepizole for Ethylene Glycol and Methanol Poisoning

• Published in: The New England journal of medicine Vol. 360; no. 21; pp. 2216 - 2223
• Main Author: Brent, Jeffrey
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 21.05.2009
• Subjects: Acidosis - chemically induced; Adult; Antidotes - adverse effects; Antidotes - therapeutic use; Biological and medical sciences; Blood Chemical Analysis; Chemical industry; Ethylene Glycol - blood; Ethylene Glycol - poisoning; General aspects; Humans; Male; Medical sciences; Metabolism; Metabolites; Methanol - poisoning; Osmolar Concentration; Paint removers; Poisoning - diagnosis; Poisoning - drug therapy; Poisoning - physiopathology; Poisons; Practice Guidelines as Topic; Pyrazoles - adverse effects; Pyrazoles - therapeutic use; Suicide, Attempted; United States > US; Medicine; Ethylene glycol; Poisoning; Antidote; Fomepizole; Methanol

A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. His pH is 7.30, and his urinalysis reveals calcium oxalate crystals, findings consistent with ethylene glycol poisoning. Treatment with fomepizole is recommended. Fomepizole is a competitive inhibitor of...