Fomepizole for Ethylene Glycol and Methanol Poisoning

A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. His pH is 7.30, and his urinalysis reveals calcium oxalate crystals, findings consistent with ethylene glycol poisoning. Treatment with fomepizole is recommended. Fomepizole is a competitive inhibitor of...

Full description

Saved in:

Bibliographic Details
Published in	The New England journal of medicine Vol. 360; no. 21; pp. 2216 - 2223
Main Author	Brent, Jeffrey
Format	Journal Article
Language	English
Published	Waltham, MA Massachusetts Medical Society 21.05.2009
Subjects	Acidosis - chemically induced Adult Antidotes - adverse effects Antidotes - therapeutic use Biological and medical sciences Blood Chemical Analysis Chemical industry Ethylene Glycol - blood Ethylene Glycol - poisoning General aspects Humans Male Medical sciences Metabolism Metabolites Methanol - poisoning Osmolar Concentration Paint removers Poisoning - diagnosis Poisoning - drug therapy Poisoning - physiopathology Poisons Practice Guidelines as Topic Pyrazoles - adverse effects Pyrazoles - therapeutic use Suicide, Attempted United States > US Medicine Ethylene glycol Poisoning Antidote Fomepizole Methanol
Online Access	Get full text

Cover

Loading…

Abstract	A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. His pH is 7.30, and his urinalysis reveals calcium oxalate crystals, findings consistent with ethylene glycol poisoning. Treatment with fomepizole is recommended. Fomepizole is a competitive inhibitor of alcohol dehydrogenase that prevents the formation of the toxic metabolites of ethylene glycol and methanol. A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. Treatment with fomepizole is recommended. Fomepizole is a competitive inhibitor of alcohol dehydrogenase that prevents the formation of the toxic metabolites of ethylene glycol and methanol. Foreword This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations. Stage A 35-year-old man is brought to the emergency department by his wife after ingesting automobile antifreeze in an attempt at self-harm. On presentation, the patient is somnolent. He is afebrile and has a blood pressure of 126/72 mm Hg, a pulse rate of 102 beats per minute, and a respiratory rate of 24 breaths per minute. Pulse oximetry shows a hemoglobin saturation of 97% while the patient is breathing ambient air. His physical examination is normal except for tachypnea. His serum electrolyte profile and creatinine level are normal except for a serum carbon dioxide level of 17 mmol per . . .
AbstractList	A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. His pH is 7.30, and his urinalysis reveals calcium oxalate crystals, findings consistent with ethylene glycol poisoning. Treatment with fomepizole is recommended. Fomepizole is a competitive inhibitor of alcohol dehydrogenase that prevents the formation of the toxic metabolites of ethylene glycol and methanol. A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. Treatment with fomepizole is recommended. Fomepizole is a competitive inhibitor of alcohol dehydrogenase that prevents the formation of the toxic metabolites of ethylene glycol and methanol. Foreword This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations. Stage A 35-year-old man is brought to the emergency department by his wife after ingesting automobile antifreeze in an attempt at self-harm. On presentation, the patient is somnolent. He is afebrile and has a blood pressure of 126/72 mm Hg, a pulse rate of 102 beats per minute, and a respiratory rate of 24 breaths per minute. Pulse oximetry shows a hemoglobin saturation of 97% while the patient is breathing ambient air. His physical examination is normal except for tachypnea. His serum electrolyte profile and creatinine level are normal except for a serum carbon dioxide level of 17 mmol per . . . A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. His pH is 7.30, and his urinalysis reveals calcium oxalate crystals, findings consistent with ethylene glycol poisoning. Treatment with fomepizole is recommended. Fomepizole is a competitive inhibitor of alcohol dehydrogenase that prevents the formation of the toxic metabolites of ethylene glycol and methanol.
Author	Brent, Jeffrey
Author_xml	– sequence: 1 givenname: Jeffrey surname: Brent fullname: Brent, Jeffrey
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21492155$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19458366$$D View this record in MEDLINE/PubMed
BookMark	eNp10c9L7DAQB_Agiq4_jl6lCHqrTpImaY6yrL4n_jrouaRpqlnSZE26h31_vRHXJwrmMgQ-Mwzf2UWbPniD0CGGMwyMn9_Nrm_1CDVwjMkGmmBGaVlVwDfRBIDUZSUk3UG7Kc0hP1zJbbSDZcVqyvkEscswmIX9F5wp-hCL2fiycsab4sqtdHCF8l1xa8YX5fPnIdgUvPXP-2irVy6Zg3XdQ0-Xs8fpn_Lm_urv9OKm1BUWY1kZaqATvJMEtKqpZNBTzDiApD3va9F1rAMlQYtcWy3algMVRDCpSGtquodOP-YuYnhdmjQ2g03aOKe8CcvUcEGYrAnN8PgHnIdl9Hm3hhAqQeZAMjpao2U7mK5ZRDuouGo-08jgZA1U0sr1UXlt039HcngEM5Zd-eF0DClF03-Ngub9Ks23q2RPf3htRzXa4MeorPu1a73NMKTGm_nwi3sDjMWYKw
CODEN	NEJMAG
CitedBy_id	crossref_primary_10_1111_j_1542_4758_2009_00427_x crossref_primary_10_1002_cpt_1306 crossref_primary_10_1016_j_mayocp_2020_07_042 crossref_primary_10_1038_clpt_2010_157 crossref_primary_10_1016_j_ultsonch_2023_106733 crossref_primary_10_2165_11584250_000000000_00000 crossref_primary_10_1080_03602532_2021_1923728 crossref_primary_10_1016_j_emc_2010_03_006 crossref_primary_10_1056_NEJMra1615295 crossref_primary_10_1016_j_annfar_2014_04_010 crossref_primary_10_1080_15563650_2021_1996591 crossref_primary_10_1007_s13181_011_0206_y crossref_primary_10_1093_toxsci_kfq167 crossref_primary_10_3390_jcm12134282 crossref_primary_10_1016_j_drugalcdep_2023_111024 crossref_primary_10_1111_bcpt_12276 crossref_primary_10_1016_j_arcmed_2016_12_010 crossref_primary_10_1111_bcp_16232 crossref_primary_10_1002_jja2_12212 crossref_primary_10_1016_j_jemermed_2020_03_024 crossref_primary_10_5507_bp_2015_008 crossref_primary_10_17986_blm_1336 crossref_primary_10_1007_s13730_022_00744_9 crossref_primary_10_1016_j_cca_2013_09_039 crossref_primary_10_1016_j_pedneo_2013_08_009 crossref_primary_10_1056_NEJMc091309 crossref_primary_10_1111_bcp_12824 crossref_primary_10_1177_0897190011400552 crossref_primary_10_1016_j_addr_2015_05_017 crossref_primary_10_5507_bp_2014_056 crossref_primary_10_1016_j_poly_2022_115914 crossref_primary_10_1089_ars_2021_0102 crossref_primary_10_7759_cureus_57868 crossref_primary_10_1155_2013_638057 crossref_primary_10_1016_S0034_9356_11_70028_7 crossref_primary_10_1007_s11560_016_0078_x crossref_primary_10_1177_2374289517708309 crossref_primary_10_1024_1661_8157_a003071 crossref_primary_10_36290_vnl_2019_076 crossref_primary_10_1007_s12028_023_01821_2 crossref_primary_10_1016_j_jcrc_2017_03_001 crossref_primary_10_1016_j_taap_2020_115317 crossref_primary_10_1021_acs_jmedchem_0c01502 crossref_primary_10_22537_jksct_2023_00014 crossref_primary_10_1080_15563650903086444 crossref_primary_10_1136_bcr_2013_202809 crossref_primary_10_1002_mma_5129 crossref_primary_10_1016_j_annfar_2010_11_022 crossref_primary_10_3109_15563650_2015_1056880 crossref_primary_10_1378_chest_10_2548 crossref_primary_10_1053_j_ajkd_2016_02_058 crossref_primary_10_1007_s00063_013_0223_5 crossref_primary_10_3109_15563650_2011_630320 crossref_primary_10_1016_j_emc_2022_01_008 crossref_primary_10_1093_ndtplus_sfr009 crossref_primary_10_1097_CNQ_0000000000000439 crossref_primary_10_2310_8000_2012_120526 crossref_primary_10_1007_s11739_017_1687_8 crossref_primary_10_1016_j_forsciint_2010_02_021 crossref_primary_10_1016_j_transproceed_2016_04_003 crossref_primary_10_1016_j_cca_2011_10_034 crossref_primary_10_3109_15563650_2010_495347 crossref_primary_10_3109_15563650_2012_683197 crossref_primary_10_1016_j_annfar_2014_02_010 crossref_primary_10_4155_fmc_2023_0285 crossref_primary_10_3390_jox14030065 crossref_primary_10_1136_bcr_2015_214272 crossref_primary_10_1007_s00467_023_06157_9 crossref_primary_10_1111_bcp_15596 crossref_primary_10_1016_j_jemermed_2019_04_026 crossref_primary_10_1002_jja2_12269 crossref_primary_10_1111_bcp_15594 crossref_primary_10_11144_Javeriana_umed61_2_etil crossref_primary_10_1097_PEC_0000000000000478 crossref_primary_10_1186_s40557_016_0153_9 crossref_primary_10_1080_15563650_2024_2319863 crossref_primary_10_1111_j_1525_139X_2011_00930_x crossref_primary_10_1016_j_cbi_2019_06_023 crossref_primary_10_1016_j_mpmed_2015_12_001 crossref_primary_10_1089_jop_2015_0069 crossref_primary_10_1055_s_0043_1770341 crossref_primary_10_1002_jja2_12702 crossref_primary_10_1258_acb_2012_012052 crossref_primary_10_1378_chest_10_2726 crossref_primary_10_1002_jbt_23505 crossref_primary_10_1080_00325481_2017_1308210 crossref_primary_10_1093_jat_bkv044 crossref_primary_10_2215_CJN_00010111 crossref_primary_10_3109_15563650_2011_590140 crossref_primary_10_1097_PEC_0000000000000409 crossref_primary_10_1016_j_ica_2024_122363 crossref_primary_10_1080_15563650_2021_1895202 crossref_primary_10_1016_S1286_9341_15_72232_5 crossref_primary_10_1136_pn_2022_003498 crossref_primary_10_1016_j_cca_2014_06_024 crossref_primary_10_1371_journal_pone_0143044 crossref_primary_10_1016_j_annemergmed_2011_12_001 crossref_primary_10_1016_j_mpmed_2011_11_025 crossref_primary_10_1016_j_molmet_2019_05_012 crossref_primary_10_1080_15563650_2022_2070071 crossref_primary_10_1177_0897190010388153 crossref_primary_10_1039_C5RA00837A crossref_primary_10_1016_j_toxac_2020_10_082 crossref_primary_10_1080_15563650_2019_1676899 crossref_primary_10_1080_15563650_2021_1980581 crossref_primary_10_1080_15563650_2019_1708091 crossref_primary_10_1016_j_polymdegradstab_2016_05_025 crossref_primary_10_1111_ped_13477 crossref_primary_10_15406_japlr_2017_06_00170 crossref_primary_10_1016_j_afjem_2012_10_002 crossref_primary_10_1542_peds_2022_061033 crossref_primary_10_1542_pir_32_12_549 crossref_primary_10_1016_j_ajem_2010_11_014 crossref_primary_10_1007_s00210_011_0627_9 crossref_primary_10_1016_j_optmat_2020_110694 crossref_primary_10_3390_ijerph19053092 crossref_primary_10_3109_15563650_2015_1059946 crossref_primary_10_1016_j_medin_2011_09_013 crossref_primary_10_1007_s00390_010_0184_3 crossref_primary_10_1016_j_jemermed_2013_08_068 crossref_primary_10_4009_jsdt_52_291 crossref_primary_10_1056_NEJMc1712813 crossref_primary_10_1007_s13181_010_0024_7 crossref_primary_10_1053_j_ajkd_2011_05_018 crossref_primary_10_1309_AJCPTZO0HRPKVPWM crossref_primary_10_5492_wjccm_v9_i3_54 crossref_primary_10_1136_bcr_2014_208855 crossref_primary_10_1186_s13643_018_0926_z crossref_primary_10_25130_tjas_21_3_13 crossref_primary_10_1172_JCI128709 crossref_primary_10_1371_journal_pone_0036122
Cites_doi	10.1016/0736-4679(90)90176-V 10.1080/15563650802559632 10.1016/S0140-6736(99)80015-4 10.3109/15563658708992616 10.1542/peds.106.6.1489 10.1542/peds.107.1.172 10.1006/taap.1996.0197 10.1016/0041-008X(77)90175-2 10.1081/CLT-58936 10.1016/j.annemergmed.2008.07.038 10.1097/00063110-200209000-00015 10.1097/MEJ.0b013e3282f3c13b 10.3109/15563658408992549 10.1542/peds.108.4.e77 10.1016/0003-9861(80)90318-5 10.1111/j.1530-0277.1988.tb00235.x 10.1053/ajkd.2001.26099 10.1016/0003-9861(80)90317-3 10.1007/BF02440861 10.1081/CLT-120004401 10.1007/BF00562552 10.1016/j.toxlet.2007.06.010 10.1081/CLT-100102394 10.1186/1471-227X-8-5 10.3109/15563658608995388 10.1111/j.0954-6820.1984.tb03825.x 10.3109/15563659809162613 10.1056/NEJM200102083440605 10.1056/NEJM199903183401102 10.1081/CLT-120006745 10.1073/pnas.82.11.3854 10.1097/00005792-195312000-00002 10.1097/01.pec.0000227389.99508.a7 10.1080/15287399509531942 10.1007/s001340101011 10.1097/01.PCC.0000128600.17670.FF 10.3109/15563659709001182 10.1081/CLT-100108496 10.5414/CNP64190 10.1542/peds.102.3.e31 10.1081/CLT-100102445 10.1016/j.taap.2007.11.024 10.1016/S0002-9394(02)01798-1 10.1177/0960327108095992
ContentType	Journal Article
Copyright	Copyright © 2009 Massachusetts Medical Society. All rights reserved. 2009 INIST-CNRS
Copyright_xml	– notice: Copyright © 2009 Massachusetts Medical Society. All rights reserved. – notice: 2009 INIST-CNRS
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8
DOI	10.1056/NEJMct0806112
DatabaseName	CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nursing & Allied Health Database ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database ProQuest Central Essentials Biological Science Collection (subscription) ProQuest eLibrary (NC LIVE) ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library ProQuest SciTech Premium Collection New England Journal of Medicine Biological Sciences Consumer Health Database Health Management Database Proquest Medical Database Psychology Database ProQuest Research Library (NC LIVE) Science Database (subscription) Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Research Library ProQuest Central (New) ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic
DatabaseTitleList	ProQuest One Psychology
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1533-4406
EndPage	2223
ExternalDocumentID	1722577701 19458366 21492155 10_1056_NEJMct0806112 NJ200905213602110
Genre	Clinical Therapeutics Journal Article Review
GeographicLocations	United States--US
GeographicLocations_xml	– name: United States--US
GroupedDBID	- 0R 0WA 123 186 1AW 1KJ 1VV 29N 2KS 2WC 34G 39C 3O- 3V. 4 4.4 53G 55 5D0 5RE 68V 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI 8RP AACLI AAEJM AAIKC AALRV AAPBV AAQQT AARDX AASXA AAWTL ABACO ABEFU ABEHJ ABFLS ABIVO ABOCM ABPPZ ABPTK ABQES ABQIJ ABUFD ABUWG ABWJO ACDCL ACGFS ACGOD ACJLH ACNCT ACPRK ACRZS ACVYA ADBBV ADCBC AENEX AETEA AFDAS AFFNX AFKRA AFMIJ AGNAY AHMBA AHVBC AIKQT AJJEV AJUXI AJYGW ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBAFP BBNVY BCR BCU BENPR BES BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BVXVI C45 CJ0 CO CS3 DCD DU5 DWQXO DZ EBS EJD ET EX3 F20 F5P FD8 FM. FYUFA G8K GJ GNUQQ GUQSH H13 HCIFZ HZ IH2 J5H K-O K78 KM KOO L7B LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC MVM N9A NEJ O0- O9- OHM OHT OK1 OMK OVD P-O P2P PADUT PCD PEA PQEST PQQKQ PQUKI PRINS PROAC PSQYO QJJ RHI RWL RXW S10 S6N SJFOW SJN TAE TAF TN5 TWZ U1N UCV UKR UMD UQL VQA W2G WH7 WOQ WOW X X7M XJT XYN XZL YCJ YNT YZZ ZA5 ZGI ZHY ZKB ZR0 ZXP --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 36B 6TJ AAMNW AAYOK AAYXX ABBLC ABCQX ABDPE ABDQB ABJNI ACKOT ACPFK ADRHT ADUKH ADXHL AERZD AFOSN AGFXO AGHSJ ALIPV BYPQX CCPQU CITATION HF~ HMCUK HZ~ N4W NAPCQ PHGZM PHGZT PSYQQ TEORI TUQ UKHRP XOL YFH YR2 YR5 YYP ZCA ZVN ~KM 1CY 41~ 8WZ 9M8 A6W AAQOH AAUTI ACPVT ACTDY AFFDN AFHKK D0S FA8 IQODW LPU MQT NHB PJZUB PPXIY PQGLB QZG SKT UBX WHG YHZ YQI YQJ YRY YYQ CGR CUY CVF ECM EIF NPM R.3 UIG VXZ YIF YIN Z5M 7XB BEC K0Y PKEHL Q9U 7X8
ID	FETCH-LOGICAL-c417t-4e3e0d76d920ca83950f31560093f6f87dd5d0a90c75d0bc7bb60372759a2be83
IEDL.DBID	7X7
ISSN	0028-4793 1533-4406
IngestDate	Fri Jul 11 07:01:06 EDT 2025 Sat Aug 23 12:52:49 EDT 2025 Wed Feb 19 01:49:43 EST 2025 Mon Jul 21 09:14:01 EDT 2025 Thu Apr 24 23:12:02 EDT 2025 Tue Jul 01 04:06:28 EDT 2025 Wed Nov 11 00:33:07 EST 2020
IsPeerReviewed	true
IsScholarly	true
Issue	21
Keywords	Medicine Ethylene glycol Poisoning Antidote Fomepizole Methanol
Language	English
License	CC BY 4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c417t-4e3e0d76d920ca83950f31560093f6f87dd5d0a90c75d0bc7bb60372759a2be83
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
PMID	19458366
PQID	223909406
PQPubID	40644
PageCount	8
ParticipantIDs	proquest_miscellaneous_67259823 proquest_journals_223909406 pubmed_primary_19458366 pascalfrancis_primary_21492155 crossref_primary_10_1056_NEJMct0806112 crossref_citationtrail_10_1056_NEJMct0806112 mms_nejm_10_1056_NEJMct0806112
ProviderPackageCode	DCD 7FN CITATION AAYXX
PublicationCentury	2000
PublicationDate	2009-05-21
PublicationDateYYYYMMDD	2009-05-21
PublicationDate_xml	– month: 05 year: 2009 text: 2009-05-21 day: 21
PublicationDecade	2000
PublicationPlace	Waltham, MA
PublicationPlace_xml	– name: Waltham, MA – name: United States – name: Boston
PublicationTitle	The New England journal of medicine
PublicationTitleAlternate	N Engl J Med
PublicationYear	2009
Publisher	Massachusetts Medical Society
Publisher_xml	– name: Massachusetts Medical Society
References	Brent, J, McMartin, K, Phillips, S (r008) 1999; 340 Detaille, T, Wallemacq, P, Clement de Clety, S, Vanbinst, R, Dembour, G, Hantson, P (r044) 2004; 5 Megarbane, B, Borron, SW, Trout, H (r024) 2001; 27 Baud, FJ, Bismuth, C, Garnier, R (r039) 1986; 24 Essama Mbia, J-J, Guerit, J-M, Haufroid, V, Hantson, P (r035) 2002; 134 Eells, JT, Salzman, MM, Lewandowski, MF, Murray, TG (r011) 1996; 140 Brown, MJ, Shannon, MW, Woolf, A, Boyer, EW (r045) 2001; 108 Jacobsen, D, McMartin, KE (r018) 1997; 35 Boyer, EW, Mejia, M, Woolf, A, Shannon, M (r020) 2001; 107 Clay, KL, Murphy, RC (r010) 1977; 39 McMartin, KE, Collins, TD, Hewlett, TP (r029) 1984; 22 Hovda, KE, Andersson, KS, Urdal, P, Jacobsen, D (r025) 2005; 43 Poldelski, V, Johnson, A, Wright, S, Rosa, VD, Zager, RA (r007) 2001; 38 Eells, JT, Henry, MM, Lewandowski, MF, Seme, MT, Murray, TG (r012) 2000; 21 Calello, DP, Osterhoudt, KC, Henretig, FM (r043) 2006; 22 Hantson, P, Wittebole, X, Haufroid, V (r019) 2002; 9 Benitez, JG, Swanson-Biearman, B, Krenzelok, EP (r047) 2000; 38 Jacobsen, D, Sebastian, S, Blomstrand, R, McMartin, KE (r037) 1988; 12 (r040) 2002; 40 Ingemansson, SO (r013) 1983; 158 Zittoun, J, Tonelli, AP, Marquet, J (r033) 1993; 44 (r027) 2002; 40 Bennett, IL, Cary, FH, Mitchell, GL, Cooper, MN (r003) 1953; 32 Jacobsen D, McMartin K. Methanol and formaldehyde poisoning In: Brent J, Wallace KL, Burkhart KK, Phillips SD, Donovan JW, eds. Critical care toxicology diagnosis and management of the critically poisoned patient. Philadelphia: Elsevier Mosby, 2005:895-901. Hovda, KE, Froyshov, S, Gudmundsdottir, H, Rudberg, N, Jacobsen, D (r026) 2005; 64 Jacobsen D. Ethylene glycol and other glycols. In: Brent J, Wallace KL, Burkhart KK, Phillips SD, Donovan JW, eds. Critical care toxicology diagnosis and management of the critically poisoned patient. Philadelphia: Elsevier Mosby, 2005:869-79. Garner, CD, Lee, EW, Terzo, TS, Louis-Ferdinand, RT (r014) 1995; 44 Wu, D, Cederbaum, AI (r030) 1993; 264 Jacobsen, D, Sebastian, CS, Barron, SK, Carriere, EW, McMartin, KE (r038) 1990; 8 Harry, P, Jobard, E, Briand, M, Caubet, A, Turcant, A (r048) 1998; 102 Blomstrand, R, Ellin, A, Lof, A, Ostling-Wintzell, H (r028) 1980; 199 Hovda, KE, Jacobsen, D (r031) 2008; 27 Guo, C, Cenac, TA, Li, Y, McMartin, KE (r006) 2007; 173 Sivilotti, MLA (r042) 2009; 53 McMartin, KE, Hedstrom, K-G, Tolf, B-R, Ostling-Wintzell, H, Blomstrand, R (r022) 1980; 199 Black, KA, Eells, JT, Noker, PE, Hawtrey, CA, Tephly, TR (r032) 1985; 82 Jacobsen, D, Barron, SK, Sebastian, CS, Blomstrand, R, McMartin, KE (r036) 1989; 37 Borron, SW, Megarbane, B, Baud, FJ (r023) 1999; 354 Corley, RA, Wilson, DM, Hard, GC (r005) 2008; 228 Baum, CR, Langman, CB, Oker, EE, Goldstein, CA, Aviles, SR, Makar, JK (r046) 2000; 106 Bronstein, AC, Spyker, DA, Cantilena, LR (r001) 2008; 46 Sivilotti, MLA, Burns, MJ, Aaron, CK, McMartin, KE, Brent, J (r034) 2001; 39 Lynd, LD, Richardson, JK, Purssell, RA (r049) 2008; 8 Cheng, J-T, Beysolow, TD, Kaul, B, Weisman, R, Feinfeld, DA (r015) 1987; 25 Moreau, CL, Kerns W, II, Tomaszewski, CA (r016) 1998; 36 Jacobsen, D, Ovrebo, S, Ostborg, J, Sejersted, OM (r009) 1984; 216 Barceloux, DG, Krenzelok, EP, Olson, K, Watson, W (r017) 1999; 37 Brent, J, McMartin, K, Phillips, S, Aaron, C, Kulig, K (r021) 2001; 344 Anseeuw, K, Sabbe, MB, Legrand, A (r041) 2008; 15 r020 r021 r022 r023 r017 r018 r019 r014 r015 r016 Jacobsen D (r009) 1984; 216 r010 r011 Eells JT (r012) 2000; 21 r006 r007 Hovda KE (r025) 2005; 43 r008 r002 r046 r003 r047 r004 r048 r005 r049 r042 r043 r044 r001 r045 r040 r041 r039 r035 r037 r038 Hovda KE (r026) 2005; 64 Ingemansson SO (r013) 1983; 158 r031 r032 r033 r034 r028 Wu D (r030) 1993; 264 r029 r024 r027 Jacobsen D (r036) 1989; 37 19771605 - N Engl J Med. 2009 Sep 17;361(12):1213; author reply 1213-4 19759385 - N Engl J Med. 2009 Sep 17;361(12):1213; author reply 1213-4
References_xml	– volume: 9 start-page: 278 year: 2002 end-page: 279 ident: r019 article-title: Ethanol therapy for methanol poisoning: duration and problems. publication-title: Eur J Emerg Med – volume: 37 start-page: 599 year: 1989 end-page: 604 ident: r036 article-title: Non-linear kinetics of 4-methylpyrazole in healthy human subjects. publication-title: Eur J Clin Pharmacol – volume: 40 start-page: 137 year: 2002 end-page: 143 ident: r040 article-title: Formate kinetics in methanol poisoning. publication-title: J Toxicol Clin Toxicol – reference: Jacobsen D, McMartin K. Methanol and formaldehyde poisoning In: Brent J, Wallace KL, Burkhart KK, Phillips SD, Donovan JW, eds. Critical care toxicology diagnosis and management of the critically poisoned patient. Philadelphia: Elsevier Mosby, 2005:895-901. – volume: 15 start-page: 107 year: 2008 end-page: 109 ident: r041 article-title: Methanol poisoning: the duality between `fast and cheap' and `slow and expensive.' publication-title: Eur J Emerg Med – volume: 27 start-page: 539 year: 2008 end-page: 546 ident: r031 article-title: Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning. publication-title: Hum Exp Toxicol – volume: 8 start-page: 5 year: 2008 end-page: 5 ident: r049 article-title: An evaluation of the osmole gap as a screening test for toxic alcohol poisoning. publication-title: BMC Emerg Med – volume: 36 start-page: 659 year: 1998 end-page: 666 ident: r016 article-title: Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. publication-title: J Toxicol Clin Toxicol – volume: 134 start-page: 914 year: 2002 end-page: 916 ident: r035 article-title: Fomepizole therapy for reversal of visual impairment after methanol poisoning: a case documented by visual evoked potentials investigation. publication-title: Am J Ophthalmol – volume: 64 start-page: 190 year: 2005 end-page: 197 ident: r026 article-title: Fomepizole may change indication for hemodialysis in methanol poisoning: prospective study in seven cases. publication-title: Clin Nephrol – volume: 53 start-page: 451 year: 2009 end-page: 453 ident: r042 article-title: Ethanol: tastes great! Fomepizole: less filling! publication-title: Ann Emerg Med – volume: 158 start-page: 1 year: 1983 end-page: 24 ident: r013 article-title: Studies on the effect of 4-methylpyrazole on retinal activity in the methanol poisoned monkey by recording the electroretinogram. publication-title: Acta Ophthalmol Suppl – volume: 25 start-page: 95 year: 1987 end-page: 108 ident: r015 article-title: Clearance of ethylene glycol by kidneys and hemodialysis. publication-title: J Toxicol Clin Toxicol – volume: 5 start-page: 490 year: 2004 end-page: 491 ident: r044 article-title: Fomepizole alone for severe infant ethylene glycol poisoning. publication-title: Pediatr Crit Care Med – volume: 43 start-page: 221 year: 2005 end-page: 227 ident: r025 article-title: Methanol and formate kinetics during treatment with fomepizole. publication-title: Clin Toxicol (Phila) – volume: 32 start-page: 431 year: 1953 end-page: 463 ident: r003 article-title: Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases. publication-title: Medicine (Baltimore) – volume: 40 start-page: 415 year: 2002 end-page: 446 ident: r027 article-title: American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. publication-title: J Toxicol Clin Toxicol – volume: 102 start-page: E31 year: 1998 end-page: E31 ident: r048 article-title: Ethylene glycol poisoning in a child treated with 4-methylpyrazole. publication-title: Pediatrics – volume: 354 start-page: 831 year: 1999 end-page: 831 ident: r023 article-title: Fomepizole in treatment of uncomplicated ethylene glycol poisoning. publication-title: Lancet – volume: 22 start-page: 133 year: 1984 end-page: 148 ident: r029 article-title: High pressure liquid chromatographic assay of 4-methylpryazole: measurements of plasma and urine levels. publication-title: J Toxicol Clin Toxicol – volume: 340 start-page: 832 year: 1999 end-page: 838 ident: r008 article-title: Fomepizole for the treatment of ethylene glycol poisoning. publication-title: N Engl J Med – volume: 344 start-page: 424 year: 2001 end-page: 429 ident: r021 article-title: Fomepizole for the treatment of methanol poisoning. publication-title: N Engl J Med – volume: 39 start-page: 627 year: 2001 end-page: 631 ident: r034 article-title: Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole. publication-title: J Toxicol Clin Toxicol – volume: 44 start-page: 569 year: 1993 end-page: 573 ident: r033 article-title: Pharmacokinetic comparison of leucovorin and levoleucovorin. publication-title: Eur J Clin Pharmacol – volume: 140 start-page: 58 year: 1996 end-page: 69 ident: r011 article-title: Formate-induced alterations in retinal function in methanol-intoxicated rats. publication-title: Toxicol Appl Pharmacol – volume: 12 start-page: 516 year: 1988 end-page: 522 ident: r037 article-title: 4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses. publication-title: Alcohol Clin Exp Res – volume: 108 start-page: E77 year: 2001 end-page: E77 ident: r045 article-title: Childhood methanol ingestion treated with fomepizole and hemodialysis. publication-title: Pediatrics – volume: 216 start-page: 409 year: 1984 end-page: 416 ident: r009 article-title: Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis. publication-title: Acta Med Scand – volume: 38 start-page: 339 year: 2001 end-page: 348 ident: r007 article-title: Ethylene glycol-mediated tubular injury: identification of critical metabolites and injury pathways. publication-title: Am J Kidney Dis – volume: 46 start-page: 927 year: 2008 end-page: 1057 ident: r001 article-title: 2007 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th annual report. publication-title: Clin Toxicol (Phila) – volume: 82 start-page: 3854 year: 1985 end-page: 3858 ident: r032 article-title: Role of hepatic tetrahydrofolate in the species difference in methanol toxicity. publication-title: Proc Natl Acad Sci U S A – volume: 8 start-page: 455 year: 1990 end-page: 461 ident: r038 article-title: Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans. publication-title: J Emerg Med – reference: Jacobsen D. Ethylene glycol and other glycols. In: Brent J, Wallace KL, Burkhart KK, Phillips SD, Donovan JW, eds. Critical care toxicology diagnosis and management of the critically poisoned patient. Philadelphia: Elsevier Mosby, 2005:869-79. – volume: 37 start-page: 537 year: 1999 end-page: 560 ident: r017 article-title: American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycol poisoning. publication-title: J Toxicol Clin Toxicol – volume: 24 start-page: 463 year: 1986 end-page: 483 ident: r039 article-title: 4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man. publication-title: J Toxicol Clin Toxicol – volume: 21 start-page: 321 year: 2000 end-page: 330 ident: r012 article-title: Development and characterization of a rodent model of methanol-induced retinal and optic nerve toxicity. publication-title: Neurotoxicology – volume: 107 start-page: 172 year: 2001 end-page: 173 ident: r020 article-title: Severe ethylene glycol ingestion treated without hemodialysis. publication-title: Pediatrics – volume: 228 start-page: 165 year: 2008 end-page: 178 ident: r005 article-title: Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity. publication-title: Toxicol Appl Pharmacol – volume: 173 start-page: 8 year: 2007 end-page: 16 ident: r006 article-title: Calcium oxalate, and not other metabolites, is responsible for the renal toxicity of ethylene glycol. publication-title: Toxicol Lett – volume: 199 start-page: 606 year: 1980 end-page: 614 ident: r022 article-title: Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model. publication-title: Arch Biochem Biophys – volume: 38 start-page: 795 year: 2000 end-page: 798 ident: r047 article-title: Nystagmus secondary to fomepizole administration in a pediatric patient. publication-title: J Toxicol Clin Toxicol – volume: 264 start-page: 1468 year: 1993 end-page: 1473 ident: r030 article-title: Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats. publication-title: J Pharmacol Exp Ther – volume: 44 start-page: 43 year: 1995 end-page: 56 ident: r014 article-title: Role of retinal metabolism in methanol-induced retinal toxicity. publication-title: J Toxicol Environ Health – volume: 22 start-page: 523 year: 2006 end-page: 530 ident: r043 article-title: New and novel antidotes in pediatrics. publication-title: Pediatr Emerg Care – volume: 27 start-page: 1370 year: 2001 end-page: 1378 ident: r024 article-title: Treatment of acute methanol poisoning with fomepizole. publication-title: Intensive Care Med – volume: 199 start-page: 591 year: 1980 end-page: 605 ident: r028 article-title: Biological effects and metabolic interaction after chronic and acute administration of 4-methylpyrazole and ethanol to rats. publication-title: Arch Biochem Biophys – volume: 106 start-page: 1489 year: 2000 end-page: 1491 ident: r046 article-title: Fomepizole treatment of ethylene glycol poisoning in an infant. publication-title: Pediatrics – volume: 35 start-page: 127 year: 1997 end-page: 143 ident: r018 article-title: Antidotes for methanol and ethylene glycol poisoning. publication-title: J Toxicol Clin Toxicol – volume: 39 start-page: 39 year: 1977 end-page: 49 ident: r010 article-title: On the metabolic acidosis of ethylene glycol intoxication. publication-title: Toxicol Appl Pharmacol – ident: r038 doi: 10.1016/0736-4679(90)90176-V – ident: r001 doi: 10.1080/15563650802559632 – ident: r023 doi: 10.1016/S0140-6736(99)80015-4 – ident: r015 doi: 10.3109/15563658708992616 – ident: r046 doi: 10.1542/peds.106.6.1489 – volume: 21 start-page: 321 year: 2000 ident: r012 publication-title: Neurotoxicology – ident: r020 doi: 10.1542/peds.107.1.172 – ident: r011 doi: 10.1006/taap.1996.0197 – ident: r010 doi: 10.1016/0041-008X(77)90175-2 – volume: 43 start-page: 221 year: 2005 ident: r025 publication-title: Clin Toxicol (Phila) doi: 10.1081/CLT-58936 – ident: r042 doi: 10.1016/j.annemergmed.2008.07.038 – ident: r019 doi: 10.1097/00063110-200209000-00015 – ident: r041 doi: 10.1097/MEJ.0b013e3282f3c13b – ident: r029 doi: 10.3109/15563658408992549 – volume: 158 start-page: 1 year: 1983 ident: r013 publication-title: Acta Ophthalmol Suppl – ident: r045 doi: 10.1542/peds.108.4.e77 – ident: r022 doi: 10.1016/0003-9861(80)90318-5 – ident: r002 – ident: r037 doi: 10.1111/j.1530-0277.1988.tb00235.x – ident: r007 doi: 10.1053/ajkd.2001.26099 – ident: r028 doi: 10.1016/0003-9861(80)90317-3 – ident: r033 doi: 10.1007/BF02440861 – ident: r040 doi: 10.1081/CLT-120004401 – volume: 37 start-page: 599 year: 1989 ident: r036 publication-title: Eur J Clin Pharmacol doi: 10.1007/BF00562552 – volume: 264 start-page: 1468 year: 1993 ident: r030 publication-title: J Pharmacol Exp Ther – ident: r006 doi: 10.1016/j.toxlet.2007.06.010 – ident: r047 doi: 10.1081/CLT-100102394 – ident: r049 doi: 10.1186/1471-227X-8-5 – ident: r039 doi: 10.3109/15563658608995388 – volume: 216 start-page: 409 year: 1984 ident: r009 publication-title: Acta Med Scand doi: 10.1111/j.0954-6820.1984.tb03825.x – ident: r016 doi: 10.3109/15563659809162613 – ident: r021 doi: 10.1056/NEJM200102083440605 – ident: r008 doi: 10.1056/NEJM199903183401102 – ident: r027 doi: 10.1081/CLT-120006745 – ident: r032 doi: 10.1073/pnas.82.11.3854 – ident: r003 doi: 10.1097/00005792-195312000-00002 – ident: r043 doi: 10.1097/01.pec.0000227389.99508.a7 – ident: r014 doi: 10.1080/15287399509531942 – ident: r024 doi: 10.1007/s001340101011 – ident: r044 doi: 10.1097/01.PCC.0000128600.17670.FF – ident: r018 doi: 10.3109/15563659709001182 – ident: r034 doi: 10.1081/CLT-100108496 – volume: 64 start-page: 190 year: 2005 ident: r026 publication-title: Clin Nephrol doi: 10.5414/CNP64190 – ident: r048 doi: 10.1542/peds.102.3.e31 – ident: r004 – ident: r017 doi: 10.1081/CLT-100102445 – ident: r005 doi: 10.1016/j.taap.2007.11.024 – ident: r035 doi: 10.1016/S0002-9394(02)01798-1 – ident: r031 doi: 10.1177/0960327108095992 – reference: 19759385 - N Engl J Med. 2009 Sep 17;361(12):1213; author reply 1213-4 – reference: 19771605 - N Engl J Med. 2009 Sep 17;361(12):1213; author reply 1213-4
SSID	ssj0000149
Score	2.3504353
SecondaryResourceType	review_article
Snippet	A 35-year-old man is brought to the emergency department after ingesting automobile antifreeze. His pH is 7.30, and his urinalysis reveals calcium oxalate...
SourceID	proquest pubmed pascalfrancis crossref mms
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	2216
SubjectTerms	Acidosis - chemically induced Adult Antidotes - adverse effects Antidotes - therapeutic use Biological and medical sciences Blood Chemical Analysis Chemical industry Ethylene Glycol - blood Ethylene Glycol - poisoning General aspects Humans Male Medical sciences Metabolism Metabolites Methanol - poisoning Osmolar Concentration Paint removers Poisoning - diagnosis Poisoning - drug therapy Poisoning - physiopathology Poisons Practice Guidelines as Topic Pyrazoles - adverse effects Pyrazoles - therapeutic use Suicide, Attempted
Title	Fomepizole for Ethylene Glycol and Methanol Poisoning
URI	http://dx.doi.org/10.1056/NEJMct0806112 https://www.ncbi.nlm.nih.gov/pubmed/19458366 https://www.proquest.com/docview/223909406 https://www.proquest.com/docview/67259823
Volume	360
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NT-MwEB0BlRAXtMtngC05IE5YJHZsJycEqKVCKkIIpN4ix3EkUJt0N-0Bfv2OE7dsD90cEkWxLGvG9nvyTN4AXMQ0j2WcxYRHmhNk4JQgjZBEZSzhKsgoa9T1h09i8BY9jvjI5ebULq1ysSc2G3VeaXtGfo0wllitN3Ez_U1s0SgbXHUVNDahY5XLbEaXHMl_1KMc-3UHSE5iEyH_2haa1zNkSyIM6QokbU4mtU2QVDXaqGiLW6xnnw0K9X_ArqOP_m3r75-wYco92B66APk-8H41MdP3r2psfKSjfg_9gLhi_IfxJ7rcV2XuD409LseX58qmEiF2HcBbv_d6PyCuMgLRUShnJDLMBLkUeUIDrZDj8KBg9p_oIGGFKGKZ5zwPVBJoic9MyywTAUOqwhNFMxOzQ9gqq9Icg69wAceGKs2kiZKIKiUVXoj7BTdRJD24Whgn1U423FavGKdN-JqLdMWWHlwum09bvYx1Dbto6bQ0H5O1DVacsOyOoluRqHAPThdeSd3Cq9PlNPHgfPkVV4wNg6jSVPM6FZJa1ULmwVHryu-BJjaKLMTJf3s-hZ02pMQJDc9ga_Znbn4hM5ll3Wb-4T2-D7vQues9Pb_8Bd3J3rA
linkProvider	ProQuest
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1NT9tAEB1BkFouVemnSws-QE9d4eynfUBVW5KGQiJUgcTNXa_XUlFip3VQRf8T_7Gz8TqQQ3rDF8vyamXNm915u7N-A7AX0zxWcRYTwY0gyMApQRqhiM5YInSUUTZX1x-O5OCCf7sUl2tw2_4L445VtnPifKLOK-P2yA8wjCVO601-nP4irmiUS662FTQarzixN39wxVYfHh8hvPuU9nvnXwbEFxUghnfVjHDLbJQrmSc0MhrpgYgK5n4nxqV9IYtY5bnII51ERuE9MyrLZMQwyotE08zGDPtdhw3OcCXTgY3PvdHZ93t6VZ5v-y0rL-qJJOPAlbY3M-RnstulS0FwfTKp3ZFMXSMqRVNOYzXfnce9_lN44glr-KnxsC1Ys-UzeDT0KfnnIPrVxE5__q3GNkQCHPYQeYxkNvw6vkEnC3WZh0PrNujx4axyh5cwWr6Aiwcx20volFVpX0OoccqILdWGKcsTTrVWGi9kGoWwnKsAPrTGSY0XKnf1MsbpPGEuZLpkywDeL5pPG4WOVQ130NJpaa8mKxssgbDojiKsSI1EANstKqkf6nW6cMwAdhdvcYy6xIsubXVdp1JRp5PIAnjVQHn3oYnLW0v55r8978LjwfnwND09Hp1sw2aT0BKEdt9CZ_b72r5DXjTLdrw3hvDjoQfAP91EGaE
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT9wwEB7BVkJcqj54BFrIoeWEtYkd28mhqqrC8uoiDiDtLTiOI1HtJkuzqNr-s_67jhNn2z1sb-QSRbasaOaz57NnPAPwIaZ5LOMsJjzSnCADpwRphCQqYwlXQUZZk11_eC3O76LLER-twe_uLowNq-zWxGahzittz8j7aMYSm-tN9AsXFXFzMvg8fSS2gJR1tHbVNFqEXJn5T9y91Z8uTlDVHykdnN5-PSeuwADRUShnJDLMBLkUeUIDrZAq8KBg9moxbvMLUcQyz3keqCTQEt-ZllkmAoYWnyeKZiZmOO46vJCMh3aKyZH8J3OVY97u8Mql90S60bdF7vUMmZoIQ7pkDtcnk9oGZ6oa9VO0hTVWM9_GAg5ewUtHXf0vLdZew5op38DG0Dnn3wIfVBMzffhVjY2PVNg_RQygTTP-2XiOcPNVmftDY4_q8eOmsmFMaDe34O5ZhLYNvbIqzS74CheP2FClmTRRElGlpMIHOUfBTRRJD4474aTapSy3lTPGaeM65yJdkqUHR4vu0zZXx6qOByjptDTfJys7LClhMRxFtSJJ4h7sd1pJ3aSv0wVEPThctOJstS4YVZrqqU6FpDZjIvNgp1Xl3x9NrAdbiL3_jnwIGwj79NvF9dU-bLaeLU5o-A56sx9P5j0SpFl20EDRh_vnxv4fNMoccQ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fomepizole+for+Ethylene+Glycol+and+Methanol+Poisoning&rft.jtitle=The+New+England+journal+of+medicine&rft.au=Brent%2C+Jeffrey&rft.date=2009-05-21&rft.pub=Massachusetts+Medical+Society&rft.issn=0028-4793&rft.eissn=1533-4406&rft.volume=360&rft.issue=21&rft.spage=2216&rft.epage=2223&rft_id=info:doi/10.1056%2FNEJMct0806112&rft.externalDocID=NJ200905213602110
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon