Physiological Apoptotic Agents have Different Effects upon Human Amnion Epithelial and Mesenchymal Cells

• Published in: Placenta (Eastbourne) Vol. 24; no. 2-3; pp. 173 - 180
• Main Authors: Moore, R.M, Silver, R.J, Moore, J.J
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.2003; Elsevier
• Subjects: 8-Bromo Cyclic Adenosine Monophosphate - pharmacology; Adult; Amnion - drug effects; Amnion - metabolism; Amnion - pathology; Apoptosis - drug effects; Biological and medical sciences; Cell Line; Cyclooxygenase Inhibitors - pharmacology; Dinoprostone - metabolism; DNA Fragmentation - drug effects; Dose-Response Relationship, Drug; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Cells - pathology; Female; Fundamental and applied biological sciences. Psychology; Humans; Immunologic Factors - pharmacology; Lactosylceramides - pharmacology; Mesoderm - drug effects; Mesoderm - metabolism; Mesoderm - pathology; Mother. Fetoplacental unit. Mammary gland. Milk; Nitrobenzenes - pharmacology; Pregnancy; Pregnancy. Parturition. Lactation; Prostaglandin D2 - analogs & derivatives; Prostaglandin D2 - pharmacology; Pyrazoles - pharmacology; Sulfonamides - pharmacology; Vertebrates: reproduction; Human; Prostaglandin-endoperoxide synthase; Prostaglandin; Fetal membrane; Enzyme; Arachidonic acid derivatives; Transferases; Enzyme inhibitor; Mesenchyma; Metabolism; Protein kinase; Eicosanoid; Ceramide; Amnion; Epithelial cell; Female; Oxidoreductases; Apoptosis

Foetal membrane rupture is thought to follow from gene-controlled tissue remodelling and apoptosis. We reported previously that staurosporine, cycloheximide, actinomycin D, as well as more physiological apoptotic agents (lactosylceramide, 15d-PGJ2) increase prostaglandin release in parallel with ind...