Lipid-modifying effects of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy

• Published in: Current medical research and opinion Vol. 20; no. 10; pp. 1571 - 1578
• Main Authors: Shepherd, James, Packard, Chris, III, Thomas W. Littlejohn, Walker, James, Stein, Evan A., Smith, Karen, Kallend, David, Blasetto, James W.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.10.2004; Taylor & Francis; Informa Healthcare
• Subjects: Administration, Oral; Aged; Blood lipids; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluorobenzenes - adverse effects; Fluorobenzenes - pharmacology; Fluorobenzenes - therapeutic use; Hormone Replacement Therapy; Humans; Hypercholesterolemia; Hypercholesterolemia - drug therapy; Lipoproteins - blood; Middle Aged; Placebos; Postmenopausal women; Postmenopause; Pyrimidines - adverse effects; Pyrimidines - pharmacology; Pyrimidines - therapeutic use; Rosuvastatin; Rosuvastatin Calcium; Sulfonamides - adverse effects; Sulfonamides - pharmacology; Sulfonamides - therapeutic use

SUMMARY Objective: To evaluate the efficacy and safety of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy (HRT) in a randomized, double-blind, placebo-controlled trial. Methods: After a 6-week dietary lead-in period, 135 postmenopausal wom...