Dietary Glucosinolate Intake, Polymorphisms in Selected Biotransformation Enzymes, and Risk of Prostate Cancer

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 19; no. 1; pp. 135 - 143
• Main Authors: Steinbrecher, Astrid, Rohrmann, Sabine, Timofeeva, Maria, Risch, Angela, Jansen, Eugène, Linseisen, Jakob
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.01.2010
• Subjects: Biological and medical sciences; Biomarkers, Tumor - genetics; Biotransformation - genetics; Case-Control Studies; Cohort Studies; Diet; diet-gene interaction; Enzyme-Linked Immunosorbent Assay; Genetic Predisposition to Disease; Genotype; glucosinolates; Glucosinolates - administration & dosage; glutathione; Glutathione S-Transferase pi - genetics; Glutathione Transferase - blood; Glutathione Transferase - genetics; Humans; Isoenzymes - blood; Male; Medical sciences; Middle Aged; NAD(P)H Dehydrogenase (Quinone); Nephrology. Urinary tract diseases; nested case-control study; Polymorphism, Genetic; prostate cancer; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - genetics; Risk Factors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; transferases; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urinary system disease; Glucosinolate; Genetic variability; Prostate disease; Nutrition; Enzyme; Genotype; Risk; Malignant tumor; Feeding; Cancerology; Diet; Biotransformation; Risk factor; Male genital diseases; Prostate cancer; Cancer; Food; Polymorphism

A protective role of glucosinolates in prostate cancer development might be mediated by the induction of biotransformation enzymes. These enzymes, enhancing the elimination of carcinogens from the body, are known to be polymorphic. Therefore, we evaluated whether a possible association between gluco...