Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

• Published in: Neuron (Cambridge, Mass.) Vol. 7; no. 5; pp. 857 - 866
• Main Authors: Berkemeier, Lucy R., Winslow, John W., Kaplan, David R., Nikolics, Karoly, Goeddel, David V., Rosenthal, Arnon
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 01.11.1991; Cell Press
• Subjects: Amino Acid Sequence; Analytical, structural and metabolic biochemistry; Animals; Base Sequence; Biological and medical sciences; DNA - isolation & purification; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - physiology; Humans; Membrane Proteins - physiology; Molecular Sequence Data; Nerve Growth Factors - genetics; Nerve Growth Factors - metabolism; Nerve Growth Factors - physiology; Protein hormones. Growth factors. Cytokines; Protein-Tyrosine Kinases - physiology; Proteins; Proto-Oncogene Proteins - physiology; Rats - genetics; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Recombinant Proteins; Nerve growth factor; Homology; Aminoacid sequence; Trophic factor; Immunological method

In vertebrates, the formation and maintenance of neuronal connections are subject to regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the identification and characterization of a novel neurotrophic factor designated neurotrophin-5 (NT-5). NT-5 is structurall...