A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease

• Published in: International journal of cardiology Vol. 234; pp. 81 - 89
• Main Authors: Clayton, Zoe E, Yuen, Gloria SC, Sadeghipour, Sara, Hywood, Jack D, Wong, Jack WT, Huang, Ngan F, Ng, Martin KC, Cooke, John P, Patel, Sanjay
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: Angiogenesis; Animals; Cardiovascular; Cell Differentiation - physiology; Cell therapy; Cells, Cultured; Cellular Reprogramming - physiology; Differentiation; Disease Models, Animal; Endothelial cells; Endothelial Cells - physiology; Fibroblasts - physiology; Hindlimb - blood supply; Humans; Induced Pluripotent Stem Cells - physiology; Ischemia - metabolism; Ischemia - therapy; Mice; Mice, Inbred NOD; Mice, SCID; Myocardial Perfusion Imaging - methods; Peripheral arterial disease; Peripheral Arterial Disease - metabolism; Peripheral Arterial Disease - physiopathology; Peripheral Arterial Disease - therapy; Reprogramming; Stem Cell Transplantation - methods; Treatment Outcome; Cell therapy; human coronary artery endothelial cell; non-obese diabetic/severe combined immunodeficiency; iEC; iPSC; bioluminescence imaging; peripheral arterial disease; induced endothelial cell; Endothelial cells; Angiogenesis; HCAEC; PAD; Reprogramming; induced pluripotent stem cell; iPSC-EC; NOD/SCID; Differentiation; BLI; induced pluripotent stem cell derived endothelial cell; Peripheral arterial disease

Abstract Background Endothelial cells derived from human induced pluripotent stem cells (iPSC-ECs) promote angiogenesis, and more recently induced endothelial cells (iECs) have been generated via fibroblast trans-differentiation. These cell types have potential as treatments for peripheral arterial...