Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming

• Published in: Journal of translational medicine Vol. 23; no. 1; pp. 262 - 20
• Main Authors: Liu, Pengcheng, Huang, Fuxin, Lin, Peixu, Liu, Jiayao, Zhou, Pincheng, Wang, Jie, Sun, Huanhuan, Xing, Fan, Ma, Haiqing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.03.2025; BioMed Central; BMC
• Subjects: Amino acid metabolism; Animals; B cells; BUD23; Cancer; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Proliferation; Cellular Reprogramming; Development and progression; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes; Genetic aspects; Health aspects; Hepatocellular carcinoma; Histidine; Histidine - metabolism; Humans; Immune response; Immune suppression; Immune system; Immunotherapy; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Macrophages; Macrophages - metabolism; Male; Metabolic Reprogramming; Mice; Oncology, Experimental; Prognosis; RNA; RNA sequencing; T cells; Tumor microenvironment; Tumor Microenvironment - immunology; United States; Immune suppression; Hepatocellular carcinoma; Histidine metabolism; Prognosis; BUD23; Tumor microenvironment

Histidine metabolism is crucial in role in tumor biology, contributing to tumor progression, immune regulation, and metabolic reprogramming. In hepatocellular carcinoma (HCC), dysregulated histidine metabolism may promote tumor growth and immune evasion, although the specific mechanisms remain poorl...