Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming - Liu, Pengcheng; Huang, Fuxin; Lin, Peixu; Liu, Jiayao; Zhou, Pincheng; Wang, Jie; Sun, Huanhuan; Xing, Fan; Ma, Haiqing (Journal of translational medicine, 2025)
Keywords: Amino acid metabolism; Animals; B cells; BUD23; Cancer; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Proliferation; Cellular Reprogramming; Development and progression; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes; Genetic aspects; Health aspects; Hepatocellular carcinoma; Histidine; Histidine - metabolism; Humans; Immune response; Immune suppression; Immune system; Immunotherapy; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Macrophages; Macrophages - metabolism; Male; Metabolic Reprogramming; Mice; Oncology, Experimental; Prognosis; RNA; RNA sequencing; T cells; Tumor microenvironment; Tumor Microenvironment - immunology; United States; Immune suppression; Hepatocellular carcinoma; Histidine metabolism; Prognosis; BUD23; Tumor microenvironment