Goose parvovirus and the protein NS1 induce apoptosis through the AIF-mitochondrial pathway in goose embryo fibroblasts

• Published in: Research in veterinary science Vol. 137; pp. 68 - 76
• Main Authors: Yan, Yu-Qing, Jin, Li-bo, Wang, Yu, Lu, Song-Yan, Pei, Yi-Feng, Zhu, Dong-Wei, Pang, Fu-Sheng, Dong, Hao, Hu, Gui-Xue
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2021; Elsevier Limited
• Subjects: AIF; Anseriform dependoparvovirus 1; Apoptosis; Apoptosis-inducing factor; Aquatic birds; Cathepsin D; Depolarization; Disease prevention; Embryo fibroblasts; Embryos; Fibroblasts; Flow cytometry; geese; Gene expression; GPV; Infections; Lysosome; Membrane potential; Membranes; Mitochondria; Mitochondrial; mitochondrial membrane; NS1 protein; Parvoviruses; Pathogenesis; Plasmids; Proteins; Reactive oxygen species; ROS; Transfection; Veterinary medicine; Viral infections; viral load; Viruses; United States > US; China; Mitochondrial; GPV; AIF; Lysosome; ROS; Apoptosis

In this study, the effects of Goose parvovirus (GPV) infection as well as the possible role of NS1 protein on apoptosis induction in goose embryo fibroblast (GEF) cells were examined. Flow cytometry analysis and TUNEL assays revealed that GPV infection and NS1 transfection induced significant apopto...