A Case-Crossover Study of Fine Particulate Matter Air Pollution and Onset of Congestive Heart Failure Symptom Exacerbation Leading to Hospitalization

Persons with congestive heart failure may be susceptible to ambient air pollution. The authors evaluated the association between exposure to particulate matter with an aerodynamic diameter of <2.5 μm (PM2.5) and onset of symptom exacerbation leading to hospital admission in Baltimore, Maryland. T...

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Published inAmerican journal of epidemiology Vol. 164; no. 5; pp. 421 - 433
Main Authors Symons, J. M., Wang, L., Guallar, E., Howell, E., Dominici, F., Schwab, M., Ange, B. A., Samet, J., Ondov, J., Harrison, D., Geyh, A.
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.09.2006
Oxford Publishing Limited (England)
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Summary:Persons with congestive heart failure may be susceptible to ambient air pollution. The authors evaluated the association between exposure to particulate matter with an aerodynamic diameter of <2.5 μm (PM2.5) and onset of symptom exacerbation leading to hospital admission in Baltimore, Maryland. They used a case-crossover design for 135 case events occurring among 125 persons with prevalent congestive heart failure who were admitted to a single hospital through the emergency department during 2002. The case period was assigned using three index times: 8-hour and 24-hour periods of symptom onset and date of hospital admission. Controlling for weather, the authors detected a modest relative increase in risk for cases defined by 8-hour symptom onset for an interquartile-range increase in PM2.5 at a 2-day lag (odds ratio = 1.09, 95% confidence interval: 0.91, 1.30). A corresponding increase in risk was not observed when admission date was used to define the case period. A series of simulations based on study data indicated that the study had adequate statistical power to detect odds ratios of 1.2 or higher. Although overall findings were not statistically significant, the identification of case events defined by an 8-hour onset period may be more relevant than either a 24-hour onset period or the admission date for estimating harmful effects of air pollutant exposure on cardiovascular health.
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Correspondence to Dr. Alison Geyh, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room E6654, Baltimore, MD 21205 (e-mail: ageyh@jhsph.edu).
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ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwj206