Passive leg movement in chronic obstructive pulmonary disease: evidence of locomotor muscle vascular dysfunction

• Published in: Journal of applied physiology (1985) Vol. 128; no. 5; pp. 1402 - 1411
• Main Authors: Ives, Stephen J., Layec, Gwenael, Hart, Corey R., Trinity, Joel D., Gifford, Jayson R., Garten, Ryan S., Witman, Melissa A. H., Sorensen, Jacob R., Richardson, Russell S.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2020
• Subjects: PLM; endothelium; nitric oxide; COPD

Utilizing both the single and continuous passive leg movement (PLM) models, which induce nitric oxide (NO)-dependent hyperemia, this study provides evidence of vascular dysfunction in the locomotor muscle of patients with chronic obstructive pulmonary disease (COPD), independent of central hemodynam...