DNA methyltransferases: Mechanistic models derived from kinetic analysis

The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form of epigenetic modification. It is virtually ubiquitous, except for some notable exceptions. Site-sp...

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Published inCritical reviews in biochemistry and molecular biology Vol. 47; no. 2; pp. 97 - 193
Main Authors Malygin, Ernst G., Hattman, Stanley
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.03.2012
Taylor & Francis
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Abstract The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form of epigenetic modification. It is virtually ubiquitous, except for some notable exceptions. Site-specific methylation can be regarded as a means to increase DNA information capacity and is involved in a large spectrum of biological processes. The importance of these functions necessitates a deeper understanding of the enzymatic mechanism(s) of DNA methylation. DNA MTases fall into one of two general classes; viz. amino-MTases and [C5-cytosine]-MTases. Amino-MTases, common in prokaryotes and lower eukaryotes, catalyze methylation of the exocyclic amino group of adenine ([N6-adenine]-MTase) or cytosine ([N4-cytosine]-MTase). In contrast, [C5-cytosine]-MTases methylate the cyclic carbon-5 atom of cytosine. Characteristics of DNA MTases are highly variable, differing in their affinity to their substrates or reaction products, their kinetic parameters, or other characteristics (order of substrate binding, rate limiting step in the overall reaction). It is not possible to present a unifying account of the published kinetic analyses of DNA methylation because different authors have used different substrate DNAs and/or reaction conditions. Nevertheless, it would be useful to describe those kinetic data and the mechanistic models that have been derived from them. Thus, this review considers in turn studies carried out with the most consistently and extensively investigated [N6-adenine]-, [N4-cytosine]- and [C5-cytosine]-DNA MTases.
AbstractList The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form of epigenetic modification. It is virtually ubiquitous, except for some notable exceptions. Site-specific methylation can be regarded as a means to increase DNA information capacity and is involved in a large spectrum of biological processes. The importance of these functions necessitates a deeper understanding of the enzymatic mechanism(s) of DNA methylation. DNA MTases fall into one of two general classes; viz. amino-MTases and [C5-cytosine]-MTases. Amino-MTases, common in prokaryotes and lower eukaryotes, catalyze methylation of the exocyclic amino group of adenine ([N6-adenine]-MTase) or cytosine ([N4-cytosine]-MTase). In contrast, [C5-cytosine]-MTases methylate the cyclic carbon-5 atom of cytosine. Characteristics of DNA MTases are highly variable, differing in their affinity to their substrates or reaction products, their kinetic parameters, or other characteristics (order of substrate binding, rate limiting step in the overall reaction). It is not possible to present a unifying account of the published kinetic analyses of DNA methylation because different authors have used different substrate DNAs and/or reaction conditions. Nevertheless, it would be useful to describe those kinetic data and the mechanistic models that have been derived from them. Thus, this review considers in turn studies carried out with the most consistently and extensively investigated [N6-adenine]-, [N4-cytosine]- and [C5-cytosine]-DNA MTases.
The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form of epigenetic modification. It is virtually ubiquitous, except for some notable exceptions. Site-specific methylation can be regarded as a means to increase DNA information capacity and is involved in a large spectrum of biological processes. The importance of these functions necessitates a deeper understanding of the enzymatic mechanism(s) of DNA methylation. DNA MTases fall into one of two general classes; viz. amino-MTases and [C5-cytosine]-MTases. Amino-MTases, common in prokaryotes and lower eukaryotes, catalyze methylation of the exocyclic amino group of adenine ([N6-adenine]-MTase) or cytosine ([N4-cytosine]-MTase). In contrast, [C5-cytosine]-MTases methylate the cyclic carbon-5 atom of cytosine. Characteristics of DNA MTases are highly variable, differing in their affinity to their substrates or reaction products, their kinetic parameters, or other characteristics (order of substrate binding, rate limiting step in the overall reaction). It is not possible to present a unifying account of the published kinetic analyses of DNA methylation because different authors have used different substrate DNAs and/or reaction conditions. Nevertheless, it would be useful to describe those kinetic data and the mechanistic models that have been derived from them. Thus, this review considers in turn studies carried out with the most consistently and extensively investigated [N6-adenine]-, [N4-cytosine]- and [C5-cytosine]-DNA MTases.
Author Hattman, Stanley
Malygin, Ernst G.
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Cites_doi 10.1021/bi00034a005
10.1016/0167-4781(86)90080-1
10.3109/10409239609108722
10.1006/jmbi.1998.2389
10.1016/0076-6879(79)63010-0
10.1016/0022-2836(78)90219-X
10.1142/9789812813077_0011
10.1515/bchm.1998.379.4-5.481
10.1016/S0022-2836(75)80028-3
10.1093/nar/23.8.1380
10.1021/bi9719206
10.1023/A:1020627514839
10.1093/nar/17.11.4161
10.1021/bi9810609
10.1093/nar/gkm432
10.1073/pnas.73.3.804
10.1074/jbc.M404573200
10.1128/AAC.24.6.860
10.1126/science.282.5393.1516
10.1016/j.jmb.2005.11.003
10.1016/0014-5793(84)80228-8
10.1006/jmbi.2001.4709
10.1021/bi951883n
10.1016/S0022-2836(75)80143-4
10.1074/jbc.275.7.4912
10.1074/jbc.M213213200
10.1016/0378-1119(91)90345-C
10.1074/jbc.274.27.19269
10.1074/jbc.M408182200
10.1016/S0021-9258(18)34967-6
10.1093/nar/18.15.4369
10.1093/nar/21.15.3563
10.4161/epi.1.2.2767
10.1126/science.2237428
10.1007/s00018-004-4201-1
10.1016/S0022-2836(59)80038-3
10.1128/jb.179.10.3239-3243.1997
10.1074/jbc.274.36.25792
10.1016/S0021-9258(18)67212-6
10.1016/0005-2787(73)90115-9
10.1093/nar/27.4.1135
10.1146/annurev.ge.21.120187.000553
10.1093/nar/21.20.4659
10.1074/jbc.M101429200
10.4161/cc.1.6.270
10.1074/jbc.M005278200
10.1021/bi9600512
10.1093/nar/gkh712
10.1016/S0021-9258(17)38387-4
10.1515/bchm.385.13.373.57208
10.1074/jbc.M108864200
10.1093/nar/19.4.841
10.1111/j.1432-1033.1992.tb17301.x
10.1016/S0021-9258(19)66964-4
10.1093/hmg/9.16.2395
10.1021/bi00717a013
10.1073/pnas.95.6.2874
10.1006/jmbi.2000.4127
10.1007/978-1-4899-1666-2_4
10.1016/j.jmb.2005.02.044
10.1016/0168-9525(89)90054-1
10.1016/S0021-9258(18)88951-7
10.1006/mgme.1998.2744
10.1074/jbc.274.46.33011
10.1111/j.1432-1033.1985.tb09168.x
10.1093/nar/gki175
10.1016/S0079-6603(04)77003-8
10.1074/jbc.272.1.490
10.1016/0014-5793(83)80166-5
10.1016/S0021-9258(18)98334-1
10.1038/360606a0
10.1016/S0021-9258(18)43593-4
10.1016/S0076-6879(80)64004-X
10.1016/0092-8674(86)90873-1
10.1074/jbc.M211458200
10.1093/nar/26.4.1076
10.1074/jbc.M603388200
10.1074/jbc.274.28.19538
10.1021/bi00527a030
10.1016/0378-1119(88)90253-3
10.1074/jbc.M306038200
10.1016/S0021-9258(17)38193-0
10.1074/jbc.274.46.33002
10.1515/BC.2007.142
10.1074/jbc.274.21.14743
10.1016/S1097-2765(00)80471-2
10.1128/MMBR.57.2.434-450.1993
10.1016/j.cell.2005.02.021
10.1021/bi9615708
10.1515/BC.2009.082
10.1128/JB.181.21.6756-6762.1999
10.1126/science.182.4114.833
10.1016/0022-2836(78)90178-X
10.1093/nar/28.20.3962
10.1016/0378-1119(88)90516-1
10.1016/0926-6569(63)90227-X
10.1021/bi00700a016
10.1016/j.jmb.2006.02.028
10.1074/jbc.M010688200
10.1093/emboj/19.9.2103
10.1128/jb.179.18.5869-5877.1997
10.1021/bi9008006
10.1515/BC.2001.084
10.1021/bi961885n
10.1126/science.284.5416.967
10.1093/nar/23.18.3648
10.1023/A:1023301923025
10.1016/S0021-9258(20)81347-7
10.1016/0092-8674(93)90421-L
10.1016/0042-6822(70)90279-5
10.1093/nar/28.21.4207
10.1093/nar/25.22.4666
10.1074/jbc.M802502200
10.1006/jmbi.1999.2608
10.1093/nar/28.20.3950
10.1016/0092-8674(94)90342-5
10.1016/S0021-9258(18)61263-3
10.1021/bi00034a004
10.1021/bi9900020
10.1016/0378-1119(96)85083-9
10.1042/BJ20060854
10.1073/pnas.88.15.6394
10.1126/science.277.5331.1453
10.1074/jbc.M409786200
10.1016/0076-6879(79)63022-7
10.1093/nar/23.8.1388
10.1128/jb.169.3.939-943.1987
10.1006/jmbi.1998.2142
10.1074/jbc.M210769200
10.1074/jbc.271.2.1008
10.1016/S0021-9258(18)90972-5
10.1074/jbc.M109237200
10.1074/jbc.M306397200
10.1006/jmbi.1996.0489
10.1016/S0022-2836(02)01282-2
10.1074/jbc.273.4.2368
10.1016/S0021-9258(19)38982-3
10.1142/9789812813077_0012
10.1002/1439-7633(20020402)3:4<274::AID-CBIC274>3.0.CO;2-S
10.1016/0378-1119(92)90242-H
10.1016/S0021-9258(19)38977-X
10.1074/jbc.M706933200
10.1111/j.1432-1033.1993.tb18427.x
10.1038/nsb973
10.1074/jbc.M700866200
10.1093/nar/25.14.2702
10.1016/0092-8674(95)90060-8
10.1016/j.jtbi.2006.03.022
10.1093/nar/5.8.2991
10.1074/jbc.270.24.14389
10.1006/jmbi.1995.0577
10.1021/bi00527a028
10.1016/S0021-9258(19)84962-1
10.1074/jbc.M100404200
10.1093/nar/25.21.4393
10.1093/nar/gkj486
10.1021/bi00225a029
10.1016/S0022-2836(02)00371-6
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References Bheemanaik S (CIT0020) 2003; 278
Quignard E (CIT0129) 1985; 152
Horton JR (CIT0073) 2005; 121
Peterson SN (CIT0122) 2006; 355
Malygin EG (CIT0103) 1999; 27
Malygin EG (CIT0100) 1980
Bestor TH (CIT0018) 2000; 9
Dryden DTF (CIT0038) 1999
Tuzikov FV (CIT0158) 1997; 31
Jurkowski TP (CIT0084) 2007; 282
Mashhoon N (CIT0114) 2004; 279
Szybalski W (CIT0154) 1991; 100
Wang MX (CIT0166) 1992; 360
Cal S (CIT0030) 1997; 272
Allan BW (CIT0007) 1999; 38
Bae SH (CIT0011) 2003; 278
Brooks JE (CIT0025) 1991; 19
Lehman IR (CIT0093) 1960; 235
Kossykh VG (CIT0090) 1995; 270
Gong W (CIT0054) 1997; 25
Jeltsch A (CIT0081) 2001; 382
Reinisch KM (CIT0135) 1995; 82
Bucci C (CIT0026) 1999; 3
Flynn J (CIT0051) 1998; 37
Malygin EG (CIT0110) 2006; 242
Ianulaitis AA (CIT0075) 1984; 18
Gromova ES (CIT0058) 2003; 37
CIT0083
Marzabal S (CIT0113) 1995; 23
Thielking V (CIT0156) 1997; 378
Cheng X (CIT0031) 1993; 74
Pradhan S (CIT0126) 1997; 25
O’Gara M (CIT0119) 1999; 287
Gromova ES (CIT0057) 1994; 36
Evdokimov AA (CIT0047) 2002; 277
Heitman J (CIT0068) 1993; 15
Allan BW (CIT0005) 1996; 35
Freese E (CIT0052) 1959; 1
Vilkaitis G (CIT0164) 2000; 275
Berg OG (CIT0014) 1981; 20
Hermann A (CIT0070) 2004; 61
Sternglanz H (CIT0146) 1973; 182
Sternglanz H (CIT0145) 1973; 308
Nardone G (CIT0116) 1984; 259
Handa V (CIT0060) 2005; 348
Wilson GA (CIT0168) 1975; 97
Marinus MG (CIT0112) 1987; 21
Hattman S (CIT0063) 1978; 119
Powell LM (CIT0125) 1998; 283
Reich NO (CIT0130) 1990; 265
Urig S (CIT0159) 2002; 319
Brennan CA (CIT0024) 1986; 261
Yang Z (CIT0174) 2003; 10
Hale WB (CIT0059) 1998; 65
Lemon KP (CIT0094) 1998; 282
Seeman NC (CIT0143) 1976; 73
Jeltsch A (CIT0080) 1999; 285
Nardone G (CIT0117) 1986; 261
Zinoviev VV (CIT0177) 1998; 379
Kossykh VG (CIT0091) 1997; 179
Adams RL (CIT0003) 1986; 868
Cleland WW (CIT0032) 1963; 67
Kaszubska W (CIT0085) 1992; 118
Rein T (CIT0134) 1999; 274
Malygin EG (CIT0102) 1997; 25
Ahmad I (CIT0004) 1996; 31
Dugaiczyk A (CIT0039) 1974; 13
Greene PH (CIT0055) 1975; 99
Holz B (CIT0071) 1998; 26
Hopkins BB (CIT0072) 2004; 279
Malygin EG (CIT0101) 1989; 9
Flynn J (CIT0050) 1996; 35
Posnick LM (CIT0124) 1999; 181
Barras F (CIT0012) 1989; 5
Hattman S (CIT0061) 1970; 42
Jeltsch A (CIT0078) 1998; 37
Javor GT (CIT0076) 1983; 24
Scavetta RD (CIT0139) 2000; 28
Youngblood B (CIT0172) 2006; 281
Abdurashitov MA (CIT0001) 1996; 172
Bacolla A (CIT0009) 1999; 274
Kossykh VG (CIT0089) 1993; 21
Westley J (CIT0167) 1969
Orsi BA (CIT0120) 1979; 63
Wright R (CIT0170) 1997; 179
Hattman S (CIT0066) 2004; 77
Malone T (CIT0098) 1995; 253
Szilák L (CIT0153) 1993; 218
Pradhan S (CIT0128) 2000; 19
Zinov’ev VV (CIT0180) 2004; 38
Kurganov BI (CIT0092) 1982
Zyskind JW (CIT0182) 1986; 46
Jeltsch A (CIT0077) 1998; 275
Lindstrom WM (CIT0096) 2000; 275
Malygin EG (CIT0106) 2001; 35
Malygin EG (CIT0111) 2009; 390
Bacolla A (CIT0010) 2001; 276
Malygin EG (CIT0104) 2000; 28
Klimasauskas S (CIT0086) 1994; 76
Allan BW (CIT0006) 1998; 273
Gowher H (CIT0056) 2000; 303
Horton JR (CIT0074) 2006; 358
Bhattacharya SK (CIT0019) 1999; 274
Zinoviev VV (CIT0181) 2007; 388
Vanyushin BF (CIT0160) 2006; 301
Jeltsch A (CIT0082) 2002; 3
Dong A (CIT0037) 2004; 385
Coffin SR (CIT0034) 2009; 48
Hattman S (CIT0062) 1978; 124
Malygin EG (CIT0109) 2004; 279
Buryanov YaI (CIT0028) 1988; 74
Rose IA (CIT0136) 1980; 64
Schermelleh L (CIT0140) 2007; 35
Fatemi M (CIT0049) 2001; 309
Winter RB (CIT0169) 1981; 20
Schermelleh L (CIT0141) 2008
Thomas CB (CIT0157) 2006; 34
Bickle TA (CIT0022) 1993; 57
Berdis AJ (CIT0013) 1998; 95
Evdokimov AA (CIT0045) 2002
Malygin EG (CIT0099) 1977; 22
Reich NO (CIT0131) 1990; 265
Lesser DR (CIT0095) 1990; 250
CIT0161
Coffin SR (CIT0035) 2008; 283
Lindstrom WM (CIT0097) 2003; 325
CIT0163
CIT0165
Adams GM (CIT0002) 1997; 36
Heithoff DM (CIT0067) 1999; 284
Vertino PM (CIT0162) 1999
Blattner FR (CIT0023) 1997; 277
Ehrlich M (CIT0041) 1987; 169
Herman GE (CIT0069) 1982; 257
Rubin RA (CIT0138) 1978; 5
Szczelkun MD (CIT0149) 1995; 34
Yang AS (CIT0173) 1995; 23
Bheemanaik S (CIT0021) 2006; 399
Kossykh VG (CIT0088) 1993; 21
Zinoviev VV (CIT0175) 1983; 154
Merkiene E (CIT0115) 2005; 33
Evdokimov AA (CIT0044) 2000; 26
Reich NO (CIT0132) 1991; 30
George J (CIT0053) 1980; 255
Cleland WW (CIT0033) 1979; 63
Reich NO (CIT0133) 1993; 268
Zinoviev VV (CIT0179) 2004; 32
Surby MA (CIT0147) 1996; 35
Malygin EG (CIT0107) 2003; 278
Ovechkina LG (CIT0121) 2000; 26
Zinoviev VV (CIT0178) 2003; 278
Evdokimov AA (CIT0046) 2002; 36
Bergerat A (CIT0017) 1991; 88
Petrov NA (CIT0123) 1997; 31
Tao T (CIT0155) 1989; 17
Malygin EG (CIT0105) 2001; 35
Evdokimov AA (CIT0048) 2007; 282
Hattman S (CIT0064) 1981
Engel JD (CIT0042) 1974; 13
Bergerat A (CIT0015) 1989; 264
Shier VK (CIT0144) 2001; 276
Szczelkun MD (CIT0150) 1995; 34
Rubin RA (CIT0137) 1977; 252
Swaminathan CP (CIT0148) 2002; 277
Engel JD (CIT0043) 1978; 253
Szilák L (CIT0152) 1992; 209
Klimasauskas S (CIT0087) 1995; 23
Zinov’ev VV (CIT0176) 1996; 30
Wu JC (CIT0171) 1987; 262
Cornish-Bowden A (CIT0036) 1976
Pradhan S (CIT0127) 1999; 274
Szegedi SS (CIT0151) 2000; 28
Cal S (CIT0029) 1996; 271
O’Gara M (CIT0118) 1996; 261
Malygin EG (CIT0108) 2003; 278
Schlagman SL (CIT0142) 1988; 73
Allan BW (CIT0008) 1999; 274
Buryanov YaI (CIT0027) 1984; 168
Jeltsch A (CIT0079) 1999; 274
Bergerat A (CIT0016) 1990; 18
Ehbrecht HJ (CIT0040) 1985; 260
Hattman S (CIT0065) 1983
References_xml – volume: 34
  start-page: 10734
  year: 1995
  ident: CIT0150
  publication-title: Biochemistry
  doi: 10.1021/bi00034a005
  contributor:
    fullname: Szczelkun MD
– volume: 868
  start-page: 9
  year: 1986
  ident: CIT0003
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0167-4781(86)90080-1
  contributor:
    fullname: Adams RL
– volume-title: Principles of enzyme kinetics
  year: 1976
  ident: CIT0036
  contributor:
    fullname: Cornish-Bowden A
– volume: 31
  start-page: 361
  year: 1996
  ident: CIT0004
  publication-title: Crit Rev Biochem Mol Biol
  doi: 10.3109/10409239609108722
  contributor:
    fullname: Ahmad I
– volume: 285
  start-page: 1121
  year: 1999
  ident: CIT0080
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.1998.2389
  contributor:
    fullname: Jeltsch A
– volume: 63
  start-page: 159
  year: 1979
  ident: CIT0120
  publication-title: Meth Enzymol
  doi: 10.1016/0076-6879(79)63010-0
  contributor:
    fullname: Orsi BA
– volume: 301
  start-page: 67
  year: 2006
  ident: CIT0160
  publication-title: Curr Top Microbiol Immunol
  contributor:
    fullname: Vanyushin BF
– volume: 119
  start-page: 361
  year: 1978
  ident: CIT0063
  publication-title: J Mol Biol
  doi: 10.1016/0022-2836(78)90219-X
  contributor:
    fullname: Hattman S
– start-page: 283
  volume-title: S-Adenosylmethionine-dependent methyltransferases, structures and functions
  year: 1999
  ident: CIT0038
  doi: 10.1142/9789812813077_0011
  contributor:
    fullname: Dryden DTF
– volume: 379
  start-page: 481
  year: 1998
  ident: CIT0177
  publication-title: Biol Chem
  doi: 10.1515/bchm.1998.379.4-5.481
  contributor:
    fullname: Zinoviev VV
– volume: 97
  start-page: 123
  year: 1975
  ident: CIT0168
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(75)80028-3
  contributor:
    fullname: Wilson GA
– volume: 23
  start-page: 1380
  year: 1995
  ident: CIT0173
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/23.8.1380
  contributor:
    fullname: Yang AS
– volume: 37
  start-page: 2160
  year: 1998
  ident: CIT0078
  publication-title: Biochemistry
  doi: 10.1021/bi9719206
  contributor:
    fullname: Jeltsch A
– volume: 36
  start-page: 849
  year: 2002
  ident: CIT0046
  publication-title: Mol Biol (Mosk)
  doi: 10.1023/A:1020627514839
  contributor:
    fullname: Evdokimov AA
– volume: 17
  start-page: 4161
  year: 1989
  ident: CIT0155
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/17.11.4161
  contributor:
    fullname: Tao T
– volume: 37
  start-page: 15162
  year: 1998
  ident: CIT0051
  publication-title: Biochemistry
  doi: 10.1021/bi9810609
  contributor:
    fullname: Flynn J
– volume: 35
  start-page: 4301
  year: 2007
  ident: CIT0140
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkm432
  contributor:
    fullname: Schermelleh L
– volume: 73
  start-page: 804
  year: 1976
  ident: CIT0143
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.73.3.804
  contributor:
    fullname: Seeman NC
– volume: 279
  start-page: 37049
  year: 2004
  ident: CIT0072
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M404573200
  contributor:
    fullname: Hopkins BB
– volume: 275
  start-page: 747
  year: 1998
  ident: CIT0077
  publication-title: J Mol Biol
  doi: 10.1128/AAC.24.6.860
  contributor:
    fullname: Jeltsch A
– volume: 35
  start-page: 65
  year: 2001
  ident: CIT0106
  publication-title: Mol Biol (Mosk)
  contributor:
    fullname: Malygin EG
– volume: 282
  start-page: 1516
  year: 1998
  ident: CIT0094
  publication-title: Science
  doi: 10.1126/science.282.5393.1516
  contributor:
    fullname: Lemon KP
– volume: 355
  start-page: 459
  year: 2006
  ident: CIT0122
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2005.11.003
  contributor:
    fullname: Peterson SN
– volume: 168
  start-page: 166
  year: 1984
  ident: CIT0027
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(84)80228-8
  contributor:
    fullname: Buryanov YaI
– volume: 309
  start-page: 1189
  year: 2001
  ident: CIT0049
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.2001.4709
  contributor:
    fullname: Fatemi M
– volume: 35
  start-page: 2201
  year: 1996
  ident: CIT0147
  publication-title: Biochemistry
  doi: 10.1021/bi951883n
  contributor:
    fullname: Surby MA
– volume: 99
  start-page: 237
  year: 1975
  ident: CIT0055
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(75)80143-4
  contributor:
    fullname: Greene PH
– volume: 9
  start-page: 87
  year: 1989
  ident: CIT0101
  publication-title: Sov Sci Rev D Physiochem Biol
  contributor:
    fullname: Malygin EG
– volume: 275
  start-page: 4912
  year: 2000
  ident: CIT0096
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.7.4912
  contributor:
    fullname: Lindstrom WM
– volume: 278
  start-page: 15713
  year: 2003
  ident: CIT0108
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M213213200
  contributor:
    fullname: Malygin EG
– volume: 100
  start-page: 13
  year: 1991
  ident: CIT0154
  publication-title: Gene
  doi: 10.1016/0378-1119(91)90345-C
  contributor:
    fullname: Szybalski W
– volume: 274
  start-page: 19269
  year: 1999
  ident: CIT0008
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.27.19269
  contributor:
    fullname: Allan BW
– volume: 24
  start-page: 860
  year: 1983
  ident: CIT0076
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.24.6.860
  contributor:
    fullname: Javor GT
– volume: 279
  start-page: 52075
  year: 2004
  ident: CIT0114
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M408182200
  contributor:
    fullname: Mashhoon N
– volume-title: Enzymic catalysis
  year: 1969
  ident: CIT0167
  contributor:
    fullname: Westley J
– volume: 257
  start-page: 2605
  year: 1982
  ident: CIT0069
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)34967-6
  contributor:
    fullname: Herman GE
– volume: 18
  start-page: 4369
  year: 1990
  ident: CIT0016
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/18.15.4369
  contributor:
    fullname: Bergerat A
– volume: 21
  start-page: 3563
  year: 1993
  ident: CIT0088
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/21.15.3563
  contributor:
    fullname: Kossykh VG
– ident: CIT0083
  doi: 10.4161/epi.1.2.2767
– volume: 250
  start-page: 776
  year: 1990
  ident: CIT0095
  publication-title: Science
  doi: 10.1126/science.2237428
  contributor:
    fullname: Lesser DR
– volume: 61
  start-page: 2571
  year: 2004
  ident: CIT0070
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-004-4201-1
  contributor:
    fullname: Hermann A
– volume: 1
  start-page: 87
  year: 1959
  ident: CIT0052
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(59)80038-3
  contributor:
    fullname: Freese E
– volume: 179
  start-page: 3239
  year: 1997
  ident: CIT0091
  publication-title: J Bacteriol
  doi: 10.1128/jb.179.10.3239-3243.1997
  contributor:
    fullname: Kossykh VG
– volume: 274
  start-page: 25792
  year: 1999
  ident: CIT0134
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.36.25792
  contributor:
    fullname: Rein T
– volume: 261
  start-page: 12128
  year: 1986
  ident: CIT0117
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)67212-6
  contributor:
    fullname: Nardone G
– volume: 308
  start-page: 1
  year: 1973
  ident: CIT0145
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0005-2787(73)90115-9
  contributor:
    fullname: Sternglanz H
– volume: 36
  start-page: 247
  year: 1994
  ident: CIT0057
  publication-title: Biochem Mol Biol Int
  contributor:
    fullname: Gromova ES
– volume: 27
  start-page: 1135
  year: 1999
  ident: CIT0103
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/27.4.1135
  contributor:
    fullname: Malygin EG
– volume: 21
  start-page: 113
  year: 1987
  ident: CIT0112
  publication-title: Annu Rev Genet
  doi: 10.1146/annurev.ge.21.120187.000553
  contributor:
    fullname: Marinus MG
– volume: 21
  start-page: 4659
  year: 1993
  ident: CIT0089
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/21.20.4659
  contributor:
    fullname: Kossykh VG
– ident: CIT0165
  doi: 10.1074/jbc.M101429200
– ident: CIT0163
  doi: 10.4161/cc.1.6.270
– volume: 275
  start-page: 38722
  year: 2000
  ident: CIT0164
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M005278200
  contributor:
    fullname: Vilkaitis G
– volume: 35
  start-page: 7308
  year: 1996
  ident: CIT0050
  publication-title: Biochemistry
  doi: 10.1021/bi9600512
  contributor:
    fullname: Flynn J
– volume: 378
  start-page: 407
  year: 1997
  ident: CIT0156
  publication-title: Biol Chem
  contributor:
    fullname: Thielking V
– volume: 32
  start-page: 3930
  year: 2004
  ident: CIT0179
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkh712
  contributor:
    fullname: Zinoviev VV
– volume: 261
  start-page: 7279
  year: 1986
  ident: CIT0024
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(17)38387-4
  contributor:
    fullname: Brennan CA
– volume: 385
  start-page: 373
  year: 2004
  ident: CIT0037
  publication-title: Biol Chem
  doi: 10.1515/bchm.385.13.373.57208
  contributor:
    fullname: Dong A
– volume: 277
  start-page: 279
  year: 2002
  ident: CIT0047
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M108864200
  contributor:
    fullname: Evdokimov AA
– volume: 19
  start-page: 841
  year: 1991
  ident: CIT0025
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/19.4.841
  contributor:
    fullname: Brooks JE
– volume: 209
  start-page: 391
  year: 1992
  ident: CIT0152
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1992.tb17301.x
  contributor:
    fullname: Szilák L
– volume: 252
  start-page: 7265
  year: 1977
  ident: CIT0137
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)66964-4
  contributor:
    fullname: Rubin RA
– volume: 38
  start-page: 869
  year: 2004
  ident: CIT0180
  publication-title: Mol Biol (Mosk)
  contributor:
    fullname: Zinov’ev VV
– volume: 9
  start-page: 2395
  year: 2000
  ident: CIT0018
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/9.16.2395
  contributor:
    fullname: Bestor TH
– volume: 13
  start-page: 4143
  year: 1974
  ident: CIT0042
  publication-title: Biochemistry
  doi: 10.1021/bi00717a013
  contributor:
    fullname: Engel JD
– volume: 26
  start-page: 940
  year: 2000
  ident: CIT0121
  publication-title: Bioorg Khim
  contributor:
    fullname: Ovechkina LG
– volume: 95
  start-page: 2874
  year: 1998
  ident: CIT0013
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.6.2874
  contributor:
    fullname: Berdis AJ
– volume: 303
  start-page: 93
  year: 2000
  ident: CIT0056
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.2000.4127
  contributor:
    fullname: Gowher H
– volume: 15
  start-page: 57
  year: 1993
  ident: CIT0068
  publication-title: Genet Eng (NY)
  doi: 10.1007/978-1-4899-1666-2_4
  contributor:
    fullname: Heitman J
– ident: CIT0161
– volume: 348
  start-page: 1103
  year: 2005
  ident: CIT0060
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2005.02.044
  contributor:
    fullname: Handa V
– volume: 5
  start-page: 139
  year: 1989
  ident: CIT0012
  publication-title: Trends Genet
  doi: 10.1016/0168-9525(89)90054-1
  contributor:
    fullname: Barras F
– start-page: 185
  year: 1980
  ident: CIT0100
  publication-title: Biophysics
  contributor:
    fullname: Malygin EG
– volume: 260
  start-page: 6160
  year: 1985
  ident: CIT0040
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)88951-7
  contributor:
    fullname: Ehbrecht HJ
– volume: 65
  start-page: 191
  year: 1998
  ident: CIT0059
  publication-title: Mol Genet Metab
  doi: 10.1006/mgme.1998.2744
  contributor:
    fullname: Hale WB
– volume: 274
  start-page: 33011
  year: 1999
  ident: CIT0009
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.46.33011
  contributor:
    fullname: Bacolla A
– volume: 152
  start-page: 99
  year: 1985
  ident: CIT0129
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1985.tb09168.x
  contributor:
    fullname: Quignard E
– volume: 33
  start-page: 307
  year: 2005
  ident: CIT0115
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gki175
  contributor:
    fullname: Merkiene E
– volume: 77
  start-page: 67
  year: 2004
  ident: CIT0066
  publication-title: Prog Nucleic Acid Res Mol Biol
  doi: 10.1016/S0079-6603(04)77003-8
  contributor:
    fullname: Hattman S
– volume: 272
  start-page: 490
  year: 1997
  ident: CIT0030
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.1.490
  contributor:
    fullname: Cal S
– volume: 154
  start-page: 282
  year: 1983
  ident: CIT0175
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(83)80166-5
  contributor:
    fullname: Zinoviev VV
– volume: 268
  start-page: 9191
  year: 1993
  ident: CIT0133
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)98334-1
  contributor:
    fullname: Reich NO
– volume: 360
  start-page: 606
  year: 1992
  ident: CIT0166
  publication-title: Nature
  doi: 10.1038/360606a0
  contributor:
    fullname: Wang MX
– volume: 255
  start-page: 6521
  year: 1980
  ident: CIT0053
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)43593-4
  contributor:
    fullname: George J
– volume: 64
  start-page: 47
  year: 1980
  ident: CIT0136
  publication-title: Meth Enzymol
  doi: 10.1016/S0076-6879(80)64004-X
  contributor:
    fullname: Rose IA
– volume: 46
  start-page: 489
  year: 1986
  ident: CIT0182
  publication-title: Cell
  doi: 10.1016/0092-8674(86)90873-1
  contributor:
    fullname: Zyskind JW
– volume-title: Allosteric enzymes: Kinetic behavior
  year: 1982
  ident: CIT0092
  contributor:
    fullname: Kurganov BI
– volume: 278
  start-page: 7863
  year: 2003
  ident: CIT0020
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M211458200
  contributor:
    fullname: Bheemanaik S
– volume: 26
  start-page: 1076
  year: 1998
  ident: CIT0071
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/26.4.1076
  contributor:
    fullname: Holz B
– volume: 281
  start-page: 26821
  year: 2006
  ident: CIT0172
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M603388200
  contributor:
    fullname: Youngblood B
– volume: 274
  start-page: 19538
  year: 1999
  ident: CIT0079
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.28.19538
  contributor:
    fullname: Jeltsch A
– start-page: 517
  volume-title: The Enzymes
  year: 1981
  ident: CIT0064
  contributor:
    fullname: Hattman S
– volume: 20
  start-page: 6961
  year: 1981
  ident: CIT0169
  publication-title: Biochemistry
  doi: 10.1021/bi00527a030
  contributor:
    fullname: Winter RB
– volume: 74
  start-page: 67
  year: 1988
  ident: CIT0028
  publication-title: Gene
  doi: 10.1016/0378-1119(88)90253-3
  contributor:
    fullname: Buryanov YaI
– volume: 278
  start-page: 45987
  year: 2003
  ident: CIT0011
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M306038200
  contributor:
    fullname: Bae SH
– volume: 253
  start-page: 927
  year: 1978
  ident: CIT0043
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(17)38193-0
  contributor:
    fullname: Engel JD
– volume: 26
  start-page: 797
  year: 2000
  ident: CIT0044
  publication-title: Bioorg Khim
  contributor:
    fullname: Evdokimov AA
– volume: 274
  start-page: 33002
  year: 1999
  ident: CIT0127
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.46.33002
  contributor:
    fullname: Pradhan S
– volume: 388
  start-page: 1199
  year: 2007
  ident: CIT0181
  publication-title: Biol Chem
  doi: 10.1515/BC.2007.142
  contributor:
    fullname: Zinoviev VV
– volume: 274
  start-page: 14743
  year: 1999
  ident: CIT0019
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.21.14743
  contributor:
    fullname: Bhattacharya SK
– volume: 3
  start-page: 435
  year: 1999
  ident: CIT0026
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(00)80471-2
  contributor:
    fullname: Bucci C
– volume: 57
  start-page: 434
  year: 1993
  ident: CIT0022
  publication-title: Microbiol Rev
  doi: 10.1128/MMBR.57.2.434-450.1993
  contributor:
    fullname: Bickle TA
– start-page: 152
  volume-title: Bacteriophage T4
  year: 1983
  ident: CIT0065
  contributor:
    fullname: Hattman S
– volume: 121
  start-page: 349
  year: 2005
  ident: CIT0073
  publication-title: Cell
  doi: 10.1016/j.cell.2005.02.021
  contributor:
    fullname: Horton JR
– volume: 35
  start-page: 14757
  year: 1996
  ident: CIT0005
  publication-title: Biochemistry
  doi: 10.1021/bi9615708
  contributor:
    fullname: Allan BW
– volume: 31
  start-page: 973
  year: 1997
  ident: CIT0123
  publication-title: Mol Biol (Mosk)
  contributor:
    fullname: Petrov NA
– volume: 390
  start-page: 835
  year: 2009
  ident: CIT0111
  publication-title: Biol Chem
  doi: 10.1515/BC.2009.082
  contributor:
    fullname: Malygin EG
– volume: 181
  start-page: 6756
  year: 1999
  ident: CIT0124
  publication-title: J Bacteriol
  doi: 10.1128/JB.181.21.6756-6762.1999
  contributor:
    fullname: Posnick LM
– volume: 182
  start-page: 833
  year: 1973
  ident: CIT0146
  publication-title: Science
  doi: 10.1126/science.182.4114.833
  contributor:
    fullname: Sternglanz H
– volume: 124
  start-page: 701
  year: 1978
  ident: CIT0062
  publication-title: J Mol Biol
  doi: 10.1016/0022-2836(78)90178-X
  contributor:
    fullname: Hattman S
– volume: 28
  start-page: 3962
  year: 2000
  ident: CIT0151
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/28.20.3962
  contributor:
    fullname: Szegedi SS
– volume: 73
  start-page: 517
  year: 1988
  ident: CIT0142
  publication-title: Gene
  doi: 10.1016/0378-1119(88)90516-1
  contributor:
    fullname: Schlagman SL
– volume: 18
  start-page: 115
  year: 1984
  ident: CIT0075
  publication-title: Mol Biol (Mosk)
  contributor:
    fullname: Ianulaitis AA
– volume: 67
  start-page: 188
  year: 1963
  ident: CIT0032
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0926-6569(63)90227-X
  contributor:
    fullname: Cleland WW
– volume: 13
  start-page: 503
  year: 1974
  ident: CIT0039
  publication-title: Biochemistry
  doi: 10.1021/bi00700a016
  contributor:
    fullname: Dugaiczyk A
– volume: 358
  start-page: 559
  year: 2006
  ident: CIT0074
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2006.02.028
  contributor:
    fullname: Horton JR
– volume: 276
  start-page: 14744
  year: 2001
  ident: CIT0144
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M010688200
  contributor:
    fullname: Shier VK
– volume: 19
  start-page: 2103
  year: 2000
  ident: CIT0128
  publication-title: EMBO J
  doi: 10.1093/emboj/19.9.2103
  contributor:
    fullname: Pradhan S
– volume: 179
  start-page: 5869
  year: 1997
  ident: CIT0170
  publication-title: J Bacteriol
  doi: 10.1128/jb.179.18.5869-5877.1997
  contributor:
    fullname: Wright R
– volume: 48
  start-page: 7399
  year: 2009
  ident: CIT0034
  publication-title: Biochemistry
  doi: 10.1021/bi9008006
  contributor:
    fullname: Coffin SR
– volume: 382
  start-page: 707
  year: 2001
  ident: CIT0081
  publication-title: Biol Chem
  doi: 10.1515/BC.2001.084
  contributor:
    fullname: Jeltsch A
– volume: 36
  start-page: 8284
  year: 1997
  ident: CIT0002
  publication-title: Biochemistry
  doi: 10.1021/bi961885n
  contributor:
    fullname: Adams GM
– volume: 284
  start-page: 967
  year: 1999
  ident: CIT0067
  publication-title: Science
  doi: 10.1126/science.284.5416.967
  contributor:
    fullname: Heithoff DM
– volume: 23
  start-page: 3648
  year: 1995
  ident: CIT0113
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/23.18.3648
  contributor:
    fullname: Marzabal S
– volume: 37
  start-page: 300
  year: 2003
  ident: CIT0058
  publication-title: Mol Biol (Mosk)
  doi: 10.1023/A:1023301923025
  contributor:
    fullname: Gromova ES
– volume: 235
  start-page: 3254
  year: 1960
  ident: CIT0093
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(20)81347-7
  contributor:
    fullname: Lehman IR
– volume: 74
  start-page: 299
  year: 1993
  ident: CIT0031
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90421-L
  contributor:
    fullname: Cheng X
– volume: 42
  start-page: 359
  year: 1970
  ident: CIT0061
  publication-title: Virology
  doi: 10.1016/0042-6822(70)90279-5
  contributor:
    fullname: Hattman S
– volume: 28
  start-page: 4207
  year: 2000
  ident: CIT0104
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/28.21.4207
  contributor:
    fullname: Malygin EG
– volume: 25
  start-page: 4666
  year: 1997
  ident: CIT0126
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/25.22.4666
  contributor:
    fullname: Pradhan S
– volume: 283
  start-page: 20106
  year: 2008
  ident: CIT0035
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M802502200
  contributor:
    fullname: Coffin SR
– volume: 287
  start-page: 201
  year: 1999
  ident: CIT0119
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.1999.2608
  contributor:
    fullname: O’Gara M
– volume: 28
  start-page: 3950
  year: 2000
  ident: CIT0139
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/28.20.3950
  contributor:
    fullname: Scavetta RD
– volume: 76
  start-page: 357
  year: 1994
  ident: CIT0086
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90342-5
  contributor:
    fullname: Klimasauskas S
– volume: 262
  start-page: 4778
  year: 1987
  ident: CIT0171
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)61263-3
  contributor:
    fullname: Wu JC
– volume: 34
  start-page: 10724
  year: 1995
  ident: CIT0149
  publication-title: Biochemistry
  doi: 10.1021/bi00034a004
  contributor:
    fullname: Szczelkun MD
– volume: 38
  start-page: 5308
  year: 1999
  ident: CIT0007
  publication-title: Biochemistry
  doi: 10.1021/bi9900020
  contributor:
    fullname: Allan BW
– volume: 30
  start-page: 1203
  year: 1996
  ident: CIT0176
  publication-title: Mol Biol (Mosk)
  contributor:
    fullname: Zinov’ev VV
– volume: 172
  start-page: 49
  year: 1996
  ident: CIT0001
  publication-title: Gene
  doi: 10.1016/0378-1119(96)85083-9
  contributor:
    fullname: Abdurashitov MA
– volume: 399
  start-page: 177
  year: 2006
  ident: CIT0021
  publication-title: Biochem J
  doi: 10.1042/BJ20060854
  contributor:
    fullname: Bheemanaik S
– volume: 88
  start-page: 6394
  year: 1991
  ident: CIT0017
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.88.15.6394
  contributor:
    fullname: Bergerat A
– volume: 277
  start-page: 1453
  year: 1997
  ident: CIT0023
  publication-title: Science
  doi: 10.1126/science.277.5331.1453
  contributor:
    fullname: Blattner FR
– volume: 279
  start-page: 50012
  year: 2004
  ident: CIT0109
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M409786200
  contributor:
    fullname: Malygin EG
– volume: 63
  start-page: 500
  year: 1979
  ident: CIT0033
  publication-title: Meth Enzymol
  doi: 10.1016/0076-6879(79)63022-7
  contributor:
    fullname: Cleland WW
– volume: 23
  start-page: 1388
  year: 1995
  ident: CIT0087
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/23.8.1388
  contributor:
    fullname: Klimasauskas S
– volume: 169
  start-page: 939
  year: 1987
  ident: CIT0041
  publication-title: J Bacteriol
  doi: 10.1128/jb.169.3.939-943.1987
  contributor:
    fullname: Ehrlich M
– volume: 283
  start-page: 947
  year: 1998
  ident: CIT0125
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.1998.2142
  contributor:
    fullname: Powell LM
– volume: 278
  start-page: 7829
  year: 2003
  ident: CIT0178
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M210769200
  contributor:
    fullname: Zinoviev VV
– volume: 271
  start-page: 1008
  year: 1996
  ident: CIT0029
  publication-title: J Biol Chem
  doi: 10.1074/jbc.271.2.1008
  contributor:
    fullname: Cal S
– volume: 259
  start-page: 10357
  year: 1984
  ident: CIT0116
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)90972-5
  contributor:
    fullname: Nardone G
– volume: 277
  start-page: 4042
  year: 2002
  ident: CIT0148
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109237200
  contributor:
    fullname: Swaminathan CP
– volume: 31
  start-page: 86
  year: 1997
  ident: CIT0158
  publication-title: Mol Biol (Mosk)
  contributor:
    fullname: Tuzikov FV
– volume: 278
  start-page: 41749
  year: 2003
  ident: CIT0107
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M306397200
  contributor:
    fullname: Malygin EG
– volume: 261
  start-page: 634
  year: 1996
  ident: CIT0118
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.1996.0489
  contributor:
    fullname: O’Gara M
– volume: 35
  start-page: 42
  year: 2001
  ident: CIT0105
  publication-title: Mol Biol (Mosk)
  contributor:
    fullname: Malygin EG
– volume: 325
  start-page: 711
  year: 2003
  ident: CIT0097
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(02)01282-2
  contributor:
    fullname: Lindstrom WM
– volume: 273
  start-page: 2368
  year: 1998
  ident: CIT0006
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.4.2368
  contributor:
    fullname: Allan BW
– volume: 265
  start-page: 8966
  year: 1990
  ident: CIT0131
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)38982-3
  contributor:
    fullname: Reich NO
– start-page: 341
  volume-title: S-adenosylmethionine-dependent methyltransferases, structures and functions
  year: 1999
  ident: CIT0162
  doi: 10.1142/9789812813077_0012
  contributor:
    fullname: Vertino PM
– volume: 3
  start-page: 274
  year: 2002
  ident: CIT0082
  publication-title: Chembiochem
  doi: 10.1002/1439-7633(20020402)3:4<274::AID-CBIC274>3.0.CO;2-S
  contributor:
    fullname: Jeltsch A
– volume: 118
  start-page: 5
  year: 1992
  ident: CIT0085
  publication-title: Gene
  doi: 10.1016/0378-1119(92)90242-H
  contributor:
    fullname: Kaszubska W
– volume: 265
  start-page: 8929
  year: 1990
  ident: CIT0130
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)38977-X
  contributor:
    fullname: Reich NO
– volume: 282
  start-page: 36942
  year: 2007
  ident: CIT0084
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M706933200
  contributor:
    fullname: Jurkowski TP
– volume: 218
  start-page: 727
  year: 1993
  ident: CIT0153
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1993.tb18427.x
  contributor:
    fullname: Szilák L
– volume: 10
  start-page: 849
  year: 2003
  ident: CIT0174
  publication-title: Nat Struct Biol
  doi: 10.1038/nsb973
  contributor:
    fullname: Yang Z
– volume: 282
  start-page: 26067
  year: 2007
  ident: CIT0048
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M700866200
  contributor:
    fullname: Evdokimov AA
– volume: 25
  start-page: 2702
  year: 1997
  ident: CIT0054
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/25.14.2702
  contributor:
    fullname: Gong W
– volume: 82
  start-page: 143
  year: 1995
  ident: CIT0135
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90060-8
  contributor:
    fullname: Reinisch KM
– volume: 242
  start-page: 627
  year: 2006
  ident: CIT0110
  publication-title: J Theor Biol
  doi: 10.1016/j.jtbi.2006.03.022
  contributor:
    fullname: Malygin EG
– year: 2008
  ident: CIT0141
  publication-title: Curr Protoc Cell Biol
  contributor:
    fullname: Schermelleh L
– volume: 5
  start-page: 2991
  year: 1978
  ident: CIT0138
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/5.8.2991
  contributor:
    fullname: Rubin RA
– volume: 270
  start-page: 14389
  year: 1995
  ident: CIT0090
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.24.14389
  contributor:
    fullname: Kossykh VG
– volume: 22
  start-page: 15
  year: 1977
  ident: CIT0099
  publication-title: Biofizika
  contributor:
    fullname: Malygin EG
– volume: 253
  start-page: 618
  year: 1995
  ident: CIT0098
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.1995.0577
  contributor:
    fullname: Malone T
– volume: 20
  start-page: 6929
  year: 1981
  ident: CIT0014
  publication-title: Biochemistry
  doi: 10.1021/bi00527a028
  contributor:
    fullname: Berg OG
– volume: 264
  start-page: 4064
  year: 1989
  ident: CIT0015
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)84962-1
  contributor:
    fullname: Bergerat A
– year: 2002
  ident: CIT0045
  publication-title: PhDThesis, State Research Center “Vector”
  contributor:
    fullname: Evdokimov AA
– volume: 276
  start-page: 18605
  year: 2001
  ident: CIT0010
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M100404200
  contributor:
    fullname: Bacolla A
– volume: 25
  start-page: 4393
  year: 1997
  ident: CIT0102
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/25.21.4393
  contributor:
    fullname: Malygin EG
– volume: 34
  start-page: 806
  year: 2006
  ident: CIT0157
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkj486
  contributor:
    fullname: Thomas CB
– volume: 30
  start-page: 2933
  year: 1991
  ident: CIT0132
  publication-title: Biochemistry
  doi: 10.1021/bi00225a029
  contributor:
    fullname: Reich NO
– volume: 319
  start-page: 1085
  year: 2002
  ident: CIT0159
  publication-title: J Mol Biol
  doi: 10.1016/S0022-2836(02)00371-6
  contributor:
    fullname: Urig S
SSID ssj0016785
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SecondaryResourceType review_article
Snippet The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA...
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StartPage 97
SubjectTerms Adenine - metabolism
Animals
Base flipping
Base Sequence
Cytosine - metabolism
DNA Methylation
DNA Modification Methylases - genetics
DNA Modification Methylases - metabolism
Epigenesis, Genetic
hemi-methylation
Humans
Kinetics
Models, Molecular
Molecular Sequence Data
mutational analysis
pre-steady state
processivity
S-adenosyl-L-methionine
S-Adenosylmethionine - metabolism
single turnover
Substrate Specificity
Title DNA methyltransferases: Mechanistic models derived from kinetic analysis
URI https://www.tandfonline.com/doi/abs/10.3109/10409238.2011.620942
https://www.ncbi.nlm.nih.gov/pubmed/22260147
https://search.proquest.com/docview/923579398
Volume 47
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