Differential effects of selective and non-selective NOS inhibition on renal arginine and protein metabolism during endotoxemia in rats

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 21; no. 2; pp. 111 - 117
• Main Authors: HALLEMEESCH, M.M., COBBEN, D.C.P., SOETERS, P.B., DEUTZ, N.E.P.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2002; Elsevier
• Subjects: Animals; Arginine - biosynthesis; Arginine - metabolism; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Development. Metamorphosis. Moult. Ageing; Disease Models, Animal; Endotoxemia - metabolism; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Isothiuronium - analogs & derivatives; Isothiuronium - pharmacology; Kidney - metabolism; Male; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide - metabolism; Nitric Oxide Synthase - antagonists & inhibitors; Pharmacology. Drug treatments; Protein Biosynthesis; protein turnover, arginine production, nitric oxide synthase inhibition; Proteins - metabolism; Random Allocation; Rats; Rats, Wistar; Renal failure; Sepsis - metabolism; Specific Pathogen-Free Organisms; Vertebrates: anatomy and physiology, studies on body, several organs or systems; protein turnover, arginine production, nitric oxide synthase inhibition; Rat; Enzyme; Rodentia; Selectivity; Metabolism; Biological activity; Nitric-oxide synthase; Protein; Kidney; Infection; Vertebrata; Mammalia; Arginine; Aminoacid; Animal; Turnover; Oxidoreductases; Protein synthesis inhibitor; Endotoxemia

Background and aims: The kidney is the main endogenous producer of circulating arginine. Renal arginine disposal is directed to protein synthesis, urea production and nitric oxide synthesis. The administration of nitric oxide synthase inhibitors during sepsis may be beneficial or detrimental dependi...