Herpes Simplex Virus 1 Enters Human Keratinocytes by a Nectin-1-Dependent, Rapid Plasma Membrane Fusion Pathway That Functions at Low Temperature

• Published in: Journal of virology Vol. 90; no. 22; pp. 10379 - 10389
• Main Authors: Sayers, Charlotte L., Elliott, Gillian
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.11.2016
• Subjects: Animals; Cell Adhesion Molecules - metabolism; Cell Line; Cell Line, Tumor; Cell Membrane - metabolism; Cell Membrane - virology; Chlorocebus aethiops; Endocytosis - physiology; Epidermis - metabolism; Epidermis - virology; HeLa Cells; Herpesviridae; Herpesvirus 1, Human - metabolism; Humans; Keratinocytes - metabolism; Keratinocytes - virology; Membrane Fusion - physiology; Nectins; Receptors, Virus - metabolism; Temperature; Vero Cells; Viral Envelope Proteins; Virion - metabolism; Virus Internalization; Virus-Cell Interactions

Herpes simplex virus 1 (HSV-1) infects humans through stratified epithelia that are composed primarily of keratinocytes. The route of HSV-1 entry into keratinocytes has been the subject of limited investigation, but it is proposed to involve pH-dependent endocytosis, requiring the gD-binding recepto...