Effect of 3-aminobenzamide on antigenic variation of Trypanosoma brucei

• Published in: Biochemical pharmacology Vol. 34; no. 23; p. 4151
• Main Authors: Cornelissen, A W, Michels, P A, Borst, P, Spanjer, W, Versluijs-Broers, J A, Van der Meer, C, Farzaneh, F, Shall, S
• Format: Journal Article
• Language: English
• Published: England 01.12.1985
• Subjects: Animals; Antigens, Protozoan; Benzamides - blood; Benzamides - pharmacology; DNA Repair; Female; Glycoproteins - genetics; Guinea Pigs; Mice; Nucleotidyltransferases - physiology; Poly(ADP-ribose) Polymerases; Rats; Trypanosoma brucei brucei - drug effects; Trypanosoma brucei brucei - immunology; Variant Surface Glycoproteins, Trypanosoma

African trypanosomes, like Trypanosoma brucei, depend on antigenic variation to evade the immune response of the vertebrate host. An antigenic switch corresponds to the activation of a variable surface glycoprotein (VSG) gene from a large silent repertoire. Most switches require the duplicative tran...