Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study
Bacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membrane...
Saved in:
| Published in | European journal of pharmaceutics and biopharmaceutics Vol. 86; no. 3; pp. 332 - 336 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.04.2014
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Bacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p=0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis. |
|---|---|
| AbstractList | Bacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24 h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p=0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis.Bacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24 h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p=0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis. Bacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24 h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p=0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis. Bacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p=0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis. |
| Author | Costa, P.C. Silva, N.H.C.S. Almeida, I.F. Gomes, F.P. Sousa Lobo, J.M. Pereira, T. Freire, C.S.R. Silvestre, A.J.D. |
| Author_xml | – sequence: 1 givenname: I.F. surname: Almeida fullname: Almeida, I.F. email: ifalmeida@ff.up.pt organization: Department of Drug Sciences, University of Porto, Portugal – sequence: 2 givenname: T. surname: Pereira fullname: Pereira, T. organization: Centro de Dermatologia Epidermis, Instituto CUF, Porto, Portugal – sequence: 3 givenname: N.H.C.S. surname: Silva fullname: Silva, N.H.C.S. organization: CICECO and Department of Chemistry, University of Aveiro, Portugal – sequence: 4 givenname: F.P. surname: Gomes fullname: Gomes, F.P. organization: CICECO and Department of Chemistry, University of Aveiro, Portugal – sequence: 5 givenname: A.J.D. surname: Silvestre fullname: Silvestre, A.J.D. organization: CICECO and Department of Chemistry, University of Aveiro, Portugal – sequence: 6 givenname: C.S.R. surname: Freire fullname: Freire, C.S.R. organization: CICECO and Department of Chemistry, University of Aveiro, Portugal – sequence: 7 givenname: J.M. surname: Sousa Lobo fullname: Sousa Lobo, J.M. organization: Department of Drug Sciences, University of Porto, Portugal – sequence: 8 givenname: P.C. surname: Costa fullname: Costa, P.C. organization: Department of Drug Sciences, University of Porto, Portugal |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23973717$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkb1vFDEQxS0URC6Bf4ACuaTZZbz2rr2IJon4kiLRQEVh-WMO-dhdH7b3pPvv8emShiKimil-bzTvvStyscQFCXnNoGXAhne7Fnd723bAeAuqBVDPyIYpyRsuBLsgGxj52AyCsUtylfMOAITs1Qty2fFRcsnkhvy8Na5gCmaiDqdpnWJGOuNsk1kwU5OpT-sv6nEKB0xHmo-54Jzf05uFhoUewiHS_LtuLs57U4INUygVK6s_viTPt2bK-OphXpMfnz5-v_vS3H_7_PXu5r5xgsnSdD1471xvle22xjtQVnSDBLTIhHBKdRwHaUF5iQ48s-OIwlSHdisVR8Ovydvz3X2Kf1bMRc8hn9xUC3HNmvVCVO-qE_-Bsn4QsoOhom8e0NXO6PU-hdmko37MrgLqDLgUc0641S6UGkFcSjJh0gz0qSa906ea9KkmDUrXR6q0-0f6eP1J0YezCGuWh4BJZxdwcehDQle0j-Ep-V8Wz6ws |
| CitedBy_id | crossref_primary_10_1016_j_ijbiomac_2020_07_289 crossref_primary_10_2754_avb201988040451 crossref_primary_10_3390_bioengineering9010003 crossref_primary_10_3389_fbioe_2021_804415 crossref_primary_10_3389_fbioe_2020_616467 crossref_primary_10_1016_j_msec_2020_111240 crossref_primary_10_1016_j_carbpol_2017_06_062 crossref_primary_10_3389_fmicb_2015_01012 crossref_primary_10_1039_D1RA07761A crossref_primary_10_1007_s10924_021_02079_5 crossref_primary_10_3390_pharmaceutics14081661 crossref_primary_10_1021_acsami_8b12200 crossref_primary_10_1080_09205063_2020_1787602 crossref_primary_10_1080_09205063_2024_2366646 crossref_primary_10_1007_s00253_015_7243_4 crossref_primary_10_3389_fbioe_2021_789603 crossref_primary_10_3390_ijms22126252 crossref_primary_10_1016_j_jab_2015_03_004 crossref_primary_10_1186_s13036_019_0177_0 crossref_primary_10_1016_j_ijbiomac_2020_03_030 crossref_primary_10_3389_fbioe_2021_795341 crossref_primary_10_1016_j_colcom_2014_08_001 crossref_primary_10_1088_2515_7647_abe02c crossref_primary_10_1016_j_mattod_2018_02_001 crossref_primary_10_1016_j_eurpolymj_2014_07_025 crossref_primary_10_1016_j_jconrel_2020_10_027 crossref_primary_10_1016_j_carbpol_2025_123427 crossref_primary_10_1007_s10570_017_1474_8 crossref_primary_10_1038_s41598_019_46918_x crossref_primary_10_3390_nano10122469 crossref_primary_10_1016_j_biotechadv_2015_07_009 crossref_primary_10_1016_j_carbpol_2021_118565 crossref_primary_10_22207_JPAM_18_1_32 crossref_primary_10_1021_jacs_8b11882 crossref_primary_10_1016_j_ijbiomac_2021_03_147 crossref_primary_10_1016_j_msec_2019_01_064 crossref_primary_10_1016_j_carbpol_2025_123270 crossref_primary_10_3390_ijms21041262 crossref_primary_10_1002_app_55163 crossref_primary_10_3390_ijms22062836 crossref_primary_10_1177_0885328221998033 crossref_primary_10_1016_j_chnaes_2023_02_002 crossref_primary_10_1016_j_msec_2019_109963 crossref_primary_10_1002_smsc_202200076 crossref_primary_10_1016_j_carpta_2025_100736 crossref_primary_10_1080_15440478_2022_2112797 crossref_primary_10_1007_s12649_020_01123_0 crossref_primary_10_1007_s13399_023_03940_4 crossref_primary_10_2217_fmb_2017_0154 crossref_primary_10_3390_molecules25184069 crossref_primary_10_3233_BME_171710 crossref_primary_10_1016_j_nbt_2018_12_002 crossref_primary_10_1002_smll_202003937 crossref_primary_10_1557_s43578_023_01116_4 crossref_primary_10_1016_j_carbpol_2016_05_029 crossref_primary_10_1039_D2TC05142G crossref_primary_10_1186_s12951_023_02108_6 crossref_primary_10_1016_j_msec_2015_10_016 crossref_primary_10_1177_15280837221121977 crossref_primary_10_1021_acs_langmuir_7b04403 crossref_primary_10_2174_1573401318666220908100006 crossref_primary_10_1016_j_carres_2023_108899 crossref_primary_10_1016_j_orgel_2020_105882 crossref_primary_10_1080_15440478_2021_1960232 crossref_primary_10_1080_21655979_2022_2062970 crossref_primary_10_1007_s10570_023_05624_8 crossref_primary_10_1111_1751_7915_13392 crossref_primary_10_1016_j_ijpharm_2019_01_059 crossref_primary_10_1016_j_carbpol_2017_02_093 crossref_primary_10_1016_j_ijbiomac_2022_08_056 crossref_primary_10_2174_1381612825666191011103851 crossref_primary_10_3390_molecules27238341 crossref_primary_10_3389_fbioe_2020_605374 crossref_primary_10_1007_s10570_022_05003_9 crossref_primary_10_1016_j_jobab_2021_02_003 crossref_primary_10_1007_s10924_021_02199_y crossref_primary_10_1016_j_carbpol_2016_02_019 crossref_primary_10_4155_tde_2017_0059 crossref_primary_10_1039_C7NR04994C crossref_primary_10_1016_j_matpr_2020_09_341 crossref_primary_10_1021_acs_jpcc_0c09837 crossref_primary_10_1016_j_ijpharm_2025_125254 crossref_primary_10_1007_s12221_018_8527_y crossref_primary_10_1007_s13205_024_04095_3 crossref_primary_10_1080_10826068_2016_1252923 crossref_primary_10_1016_j_jtv_2018_10_001 crossref_primary_10_3390_cosmetics5040066 crossref_primary_10_1016_j_carbpol_2021_118366 crossref_primary_10_1016_j_btre_2020_e00502 crossref_primary_10_1007_s00253_015_6426_3 crossref_primary_10_1016_j_ijbiomac_2024_137602 crossref_primary_10_1208_s12249_024_02752_7 crossref_primary_10_1016_j_ijbiomac_2023_123316 crossref_primary_10_1002_jbm_b_34191 crossref_primary_10_3390_ma15051982 crossref_primary_10_1021_acsanm_7b00105 crossref_primary_10_1038_s41598_017_18271_4 crossref_primary_10_1021_acsbiomaterials_7b00367 crossref_primary_10_1002_jbm_b_35488 crossref_primary_10_1080_15440478_2021_1964137 crossref_primary_10_1016_j_jconrel_2018_11_024 crossref_primary_10_3389_fbioe_2022_1059097 crossref_primary_10_3390_ijms21249507 crossref_primary_10_3390_nano9020164 crossref_primary_10_2478_s11532_014_0541_3 crossref_primary_10_1016_j_carbpol_2017_09_061 crossref_primary_10_1016_j_carbpol_2021_118995 crossref_primary_10_3390_nano10040628 crossref_primary_10_1016_j_carbpol_2016_07_059 crossref_primary_10_1007_s12649_022_01769_y crossref_primary_10_1021_acs_iecr_9b07066 crossref_primary_10_1007_s13399_021_01643_2 crossref_primary_10_1111_srt_12926 crossref_primary_10_1007_s10570_021_04106_z crossref_primary_10_3390_ma15031054 crossref_primary_10_1016_j_msec_2020_111350 crossref_primary_10_3390_cimb46110697 crossref_primary_10_1016_j_carbpol_2024_122656 crossref_primary_10_1038_s41598_018_29167_2 crossref_primary_10_1088_1755_1315_101_1_012010 crossref_primary_10_3390_polym13132088 crossref_primary_10_1088_1755_1315_101_1_012011 crossref_primary_10_15230_SCSK_2016_42_3_247 crossref_primary_10_1007_s10570_016_0986_y crossref_primary_10_1007_s12010_023_04794_2 crossref_primary_10_1016_j_ijbiomac_2021_05_193 crossref_primary_10_1080_10717544_2021_1977423 crossref_primary_10_1111_jocd_13051 crossref_primary_10_1016_j_ijpharm_2015_11_053 crossref_primary_10_1155_2022_1214734 crossref_primary_10_1016_j_indcrop_2023_117589 crossref_primary_10_3390_ijms22126269 crossref_primary_10_1016_j_colsurfa_2021_126380 crossref_primary_10_1007_s10570_022_04443_7 crossref_primary_10_1016_j_toxrep_2017_09_005 |
| Cites_doi | 10.1007/s13273-010-0049-7 10.1111/j.1600-0536.1997.tb02438.x 10.1016/j.ejpb.2004.02.013 10.1002/anie.200460587 10.1023/A:1004775229149 10.1111/1346-8138.12004 10.1016/S0079-6700(01)00021-1 10.12968/jowc.2011.20.11.534 10.1186/1471-2091-5-5 10.1039/c2jm00134a 10.1016/S1389-1723(04)70162-0 10.1016/j.biomaterials.2005.07.035 10.1016/j.ijpharm.2012.01.002 10.1186/1751-0147-51-12 10.1111/j.1600-0536.1997.tb00041.x 10.1021/bm201303r 10.1111/j.1600-0536.1984.tb00362.x 10.1016/j.carbpol.2011.06.046 10.1080/000155599750009825 10.1021/bm060620d 10.1111/j.1468-3083.2012.04525.x 10.1159/000111134 10.1034/j.1600-0536.2001.450506.x 10.1046/j.1467-2494.2001.00060.x 10.1080/000155502753600885 10.1034/j.1600-0846.2001.070401.x |
| ContentType | Journal Article |
| Copyright | 2013 Elsevier B.V. Copyright © 2013 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2013 Elsevier B.V. – notice: Copyright © 2013 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7QL 7QO 7T7 8FD C1K FR3 P64 |
| DOI | 10.1016/j.ejpb.2013.08.008 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Biotechnology Research Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Biotechnology Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-3441 |
| EndPage | 336 |
| ExternalDocumentID | 23973717 10_1016_j_ejpb_2013_08_008 S0939641113002877 |
| Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO AAYOK ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFO ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SES SEW SPCBC SSP SSU SSZ T5K TEORI UNMZH ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EFKBS EIF NPM 7X8 7QL 7QO 7T7 8FD C1K FR3 P64 |
| ID | FETCH-LOGICAL-c417t-250ddcc5b8b2fadc08b42670ebe144c8823e67b08d7ec0d1b99e4a441bf783ea3 |
| IEDL.DBID | .~1 |
| ISSN | 0939-6411 1873-3441 |
| IngestDate | Thu Jul 10 16:59:06 EDT 2025 Fri Jul 11 06:00:03 EDT 2025 Mon Jul 21 05:57:01 EDT 2025 Tue Jul 01 00:58:37 EDT 2025 Thu Apr 24 23:08:38 EDT 2025 Fri Feb 23 02:28:03 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Skin irritation Bacterial cellulose Drug delivery Skin compatibility Gluconoacetobacter sacchari Skin hydration |
| Language | English |
| License | Copyright © 2013 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c417t-250ddcc5b8b2fadc08b42670ebe144c8823e67b08d7ec0d1b99e4a441bf783ea3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | http://hdl.handle.net/10400.26/5927 |
| PMID | 23973717 |
| PQID | 1515647206 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_1544000824 proquest_miscellaneous_1515647206 pubmed_primary_23973717 crossref_citationtrail_10_1016_j_ejpb_2013_08_008 crossref_primary_10_1016_j_ejpb_2013_08_008 elsevier_sciencedirect_doi_10_1016_j_ejpb_2013_08_008 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-04-01 |
| PublicationDateYYYYMMDD | 2014-04-01 |
| PublicationDate_xml | – month: 04 year: 2014 text: 2014-04-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | European journal of pharmaceutics and biopharmaceutics |
| PublicationTitleAlternate | Eur J Pharm Biopharm |
| PublicationYear | 2014 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Mendes, Rahal, Pereira-Junior, Fabris, Lenharo, de Lima-Neto, Landim-Alvarenga (b0055) 2009; 51 Devaux, Castela, Archier, Gallini, Joly, Misery, Aractingi, Aubin, Bachelez, Cribier, Jullien, Le Maitre, Richard, Ortonne, Paul (b0135) 2012; 26 Lenselink, Andriessen (b0065) 2011; 20 Trovatti, Serafim, Freire, Silvestre, Neto (b0020) 2011; 86 Scuro, Simioni, Grabriel, Saviani, Modolo, Tamashiro, Salgado (b0060) 2004; 5 Klemm, Schumann, Udhardt, Marsch (b0030) 2001; 26 Jeong, Lee, Yang, Jin, Park, Park (b0050) 2010; 6 Trovatti, Freire, Pinto, Almeida, Costa, Silvestre, Neto, Rosado (b0035) 2012; 435 Fu, Zhang, Li, Wu, Zhuo, Huang, Qiu, Zhou, Yang (b0045) 2012; 22 Czaja, Young, Kawecki, Brown (b0025) 2007; 8 Loden, Andersson, Anderson, Bergbrant, Frodin, Ohman, Sandstrom, Sarnhult, Voog, Stenberg, Pawlik, Preisler-Haggqvist, Svensson, Lindberg (b0125) 2002; 82 Aramaki, Effendy, Happle, Kawana, Loffler, Loffler (b0090) 2001; 45 Klemm, Heublein, Fink, Bohn (b0005) 2005; 44 Iguchi, Yamanaka, Budhiono (b0015) 2000; 35 Trovatti, Silva, Duarte, Rosado, Almeida, Costa, Freire, Silvestre, Neto (b0040) 2011; 12 Czaja, Krystynowicz, Bielecki, Brown (b0010) 2006; 27 Flannigan, Smith, McGovern (b0075) 1984; 10 Breternitz, Kowatzki, Langenauer, Elsner, Fluhr (b0130) 2008; 21 Kanto, Washizaki, Ito, Matsunaga, Akamatsu, Kawai, Katoh, Natsuaki, Yoshimura, Kojima, Okamoto, Okuda, Kuwahara, Sugiyama, Kinoshita, Mori (b0080) 2013 Basketter, Reynolds, Rowson, Talbot, Whittle (b0085) 1997; 37 Lodén, Wessman (b0110) 2001; 23 Tupker, Willis, Berardesca, Lee, Fartasch, Agner, Serup (b0095) 1997; 37 Fluhr, Gloor, Lehmann, Lazzerini, Distante, Berardesca (b0115) 1999; 79 Jibry, Murdan (b0105) 2004; 58 Amnuaikit, Chusuit, Raknam, Boonme (b0070) 2011; 4 Loden, Andersson, Andersson, Frodin, Oman, Lindberg (b0120) 2001; 7 Bae, Sugano, Shoda (b0100) 2004; 97 Czaja (10.1016/j.ejpb.2013.08.008_b0025) 2007; 8 Amnuaikit (10.1016/j.ejpb.2013.08.008_b0070) 2011; 4 Breternitz (10.1016/j.ejpb.2013.08.008_b0130) 2008; 21 Devaux (10.1016/j.ejpb.2013.08.008_b0135) 2012; 26 Klemm (10.1016/j.ejpb.2013.08.008_b0030) 2001; 26 Fu (10.1016/j.ejpb.2013.08.008_b0045) 2012; 22 Jibry (10.1016/j.ejpb.2013.08.008_b0105) 2004; 58 Basketter (10.1016/j.ejpb.2013.08.008_b0085) 1997; 37 Klemm (10.1016/j.ejpb.2013.08.008_b0005) 2005; 44 Aramaki (10.1016/j.ejpb.2013.08.008_b0090) 2001; 45 Fluhr (10.1016/j.ejpb.2013.08.008_b0115) 1999; 79 Tupker (10.1016/j.ejpb.2013.08.008_b0095) 1997; 37 Trovatti (10.1016/j.ejpb.2013.08.008_b0040) 2011; 12 Scuro (10.1016/j.ejpb.2013.08.008_b0060) 2004; 5 Lodén (10.1016/j.ejpb.2013.08.008_b0110) 2001; 23 Bae (10.1016/j.ejpb.2013.08.008_b0100) 2004; 97 Loden (10.1016/j.ejpb.2013.08.008_b0120) 2001; 7 Kanto (10.1016/j.ejpb.2013.08.008_b0080) 2013 Loden (10.1016/j.ejpb.2013.08.008_b0125) 2002; 82 Jeong (10.1016/j.ejpb.2013.08.008_b0050) 2010; 6 Lenselink (10.1016/j.ejpb.2013.08.008_b0065) 2011; 20 Trovatti (10.1016/j.ejpb.2013.08.008_b0020) 2011; 86 Mendes (10.1016/j.ejpb.2013.08.008_b0055) 2009; 51 Trovatti (10.1016/j.ejpb.2013.08.008_b0035) 2012; 435 Iguchi (10.1016/j.ejpb.2013.08.008_b0015) 2000; 35 Flannigan (10.1016/j.ejpb.2013.08.008_b0075) 1984; 10 Czaja (10.1016/j.ejpb.2013.08.008_b0010) 2006; 27 |
| References_xml | – volume: 86 start-page: 1417 year: 2011 end-page: 1420 ident: b0020 article-title: : an efficient bacterial cellulose cell-factory publication-title: Carbohydr. Polym. – volume: 20 year: 2011 ident: b0065 article-title: A cohort study on the efficacy of a polyhexanide-containing biocellulose dressing in the treatment of biofilms in wounds publication-title: J. Wound Care – volume: 435 start-page: 83 year: 2012 end-page: 87 ident: b0035 article-title: Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies publication-title: Int. J. Pharm. – volume: 82 start-page: 45 year: 2002 end-page: 47 ident: b0125 article-title: A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients publication-title: Acta Derm. Venereol. – volume: 27 start-page: 145 year: 2006 end-page: 151 ident: b0010 article-title: Microbial cellulose – the natural power to heal wounds publication-title: Biomaterials – volume: 45 start-page: 286 year: 2001 end-page: 290 ident: b0090 article-title: Which bioengineering assay is appropriate for irritant patch testing with sodium lauryl sulfate? publication-title: Contact Dermatitis – volume: 35 start-page: 261 year: 2000 end-page: 270 ident: b0015 article-title: Bacterial cellulose – a masterpiece of nature’s arts publication-title: J. Mater. Sci. – volume: 12 start-page: 4162 year: 2011 end-page: 4168 ident: b0040 article-title: Biocellulose membranes as supports for dermal release of lidocaine publication-title: Biomacromolecules – volume: 51 year: 2009 ident: b0055 article-title: In vivo and in vitro evaluation of an Acetobacter xylinum synthesized microbial cellulose membrane intended for guided tissue repair publication-title: Acta Vet. Scand. – volume: 44 start-page: 3358 year: 2005 end-page: 3393 ident: b0005 article-title: Cellulose: fascinating biopolymer and sustainable raw material publication-title: Angew. Chem. Int. Ed. – volume: 26 start-page: 1561 year: 2001 end-page: 1603 ident: b0030 article-title: Bacterial synthesized cellulose – artificial blood vessels for microsurgery publication-title: Prog. Polym. Sci. – volume: 58 start-page: 107 year: 2004 end-page: 119 ident: b0105 article-title: In vivo investigation, in mice and in man, into the irritation potential of novel amphiphilogels being studied as transdermal drug carriers publication-title: Eur. J. Pharm. Biopharm. – volume: 26 start-page: 61 year: 2012 end-page: 67 ident: b0135 article-title: Adherence to topical treatment in psoriasis: a systematic literature review publication-title: J. Eur. Acad. Dermatol. Venereol. – volume: 22 start-page: 12349 year: 2012 end-page: 12357 ident: b0045 article-title: Skin tissue repair materials from bacterial cellulose by a multilayer fermentation method publication-title: J. Mater. Chem. – volume: 6 start-page: 373 year: 2010 end-page: 380 ident: b0050 article-title: Toxicologic evaluation of bacterial synthesized cellulose in endothelial cells and animals publication-title: Mol. Cell Toxicol. – volume: 21 start-page: 39 year: 2008 end-page: 45 ident: b0130 article-title: Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation publication-title: Skin Pharmacol. Physiol. – volume: 8 start-page: 1 year: 2007 end-page: 12 ident: b0025 article-title: The future prospects of microbial cellulose in biomedical applications publication-title: Biomacromolecules – volume: 23 start-page: 115 year: 2001 end-page: 119 ident: b0110 article-title: The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties publication-title: Int. J. Cosmet. Sci. – year: 2013 ident: b0080 article-title: Optimal patch application time in the evaluation of skin irritation publication-title: J. Dermatol. – volume: 97 start-page: 33 year: 2004 end-page: 38 ident: b0100 article-title: Improvement of bacterial cellulose production by addition of agar in a jar fermentor publication-title: J. Biosci. Bioeng. – volume: 4 start-page: 77 year: 2011 end-page: 81 ident: b0070 article-title: Effects of a cellulose mask synthesized by a bacterium on facial skin characteristics and user satisfaction publication-title: Med. Dev. – volume: 79 start-page: 418 year: 1999 end-page: 421 ident: b0115 article-title: Glycerol accelerates recovery of barrier function in vivo publication-title: Acta Derm. Venereol. – volume: 10 start-page: 123 year: 1984 end-page: 124 ident: b0075 article-title: Intraregional variation between contact irritant patch test sites publication-title: Contact Dermatitis – volume: 37 start-page: 218 year: 1997 end-page: 220 ident: b0085 article-title: Visual assessment of human skin irritation: a sensitive and reproducible tool publication-title: Contact Dermatitis – volume: 7 start-page: 209 year: 2001 end-page: 213 ident: b0120 article-title: Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis publication-title: Skin Res. Technol.: Off. J. Int. Soc. Bioeng. Skin – volume: 37 start-page: 53 year: 1997 end-page: 69 ident: b0095 article-title: Guidelines on sodium lauryl sulfate (SLS) exposure tests. A report from the standardization group of the European society of contact dermatitis publication-title: Contact Dermatitis – volume: 5 start-page: 5 year: 2004 ident: b0060 article-title: Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation publication-title: BMC Biochem. – volume: 6 start-page: 373 year: 2010 ident: 10.1016/j.ejpb.2013.08.008_b0050 article-title: Toxicologic evaluation of bacterial synthesized cellulose in endothelial cells and animals publication-title: Mol. Cell Toxicol. doi: 10.1007/s13273-010-0049-7 – volume: 37 start-page: 218 year: 1997 ident: 10.1016/j.ejpb.2013.08.008_b0085 article-title: Visual assessment of human skin irritation: a sensitive and reproducible tool publication-title: Contact Dermatitis doi: 10.1111/j.1600-0536.1997.tb02438.x – volume: 58 start-page: 107 year: 2004 ident: 10.1016/j.ejpb.2013.08.008_b0105 article-title: In vivo investigation, in mice and in man, into the irritation potential of novel amphiphilogels being studied as transdermal drug carriers publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2004.02.013 – volume: 44 start-page: 3358 year: 2005 ident: 10.1016/j.ejpb.2013.08.008_b0005 article-title: Cellulose: fascinating biopolymer and sustainable raw material publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.200460587 – volume: 35 start-page: 261 year: 2000 ident: 10.1016/j.ejpb.2013.08.008_b0015 article-title: Bacterial cellulose – a masterpiece of nature’s arts publication-title: J. Mater. Sci. doi: 10.1023/A:1004775229149 – year: 2013 ident: 10.1016/j.ejpb.2013.08.008_b0080 article-title: Optimal patch application time in the evaluation of skin irritation publication-title: J. Dermatol. doi: 10.1111/1346-8138.12004 – volume: 26 start-page: 1561 year: 2001 ident: 10.1016/j.ejpb.2013.08.008_b0030 article-title: Bacterial synthesized cellulose – artificial blood vessels for microsurgery publication-title: Prog. Polym. Sci. doi: 10.1016/S0079-6700(01)00021-1 – volume: 20 year: 2011 ident: 10.1016/j.ejpb.2013.08.008_b0065 article-title: A cohort study on the efficacy of a polyhexanide-containing biocellulose dressing in the treatment of biofilms in wounds publication-title: J. Wound Care doi: 10.12968/jowc.2011.20.11.534 – volume: 5 start-page: 5 year: 2004 ident: 10.1016/j.ejpb.2013.08.008_b0060 article-title: Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation publication-title: BMC Biochem. doi: 10.1186/1471-2091-5-5 – volume: 22 start-page: 12349 year: 2012 ident: 10.1016/j.ejpb.2013.08.008_b0045 article-title: Skin tissue repair materials from bacterial cellulose by a multilayer fermentation method publication-title: J. Mater. Chem. doi: 10.1039/c2jm00134a – volume: 4 start-page: 77 year: 2011 ident: 10.1016/j.ejpb.2013.08.008_b0070 article-title: Effects of a cellulose mask synthesized by a bacterium on facial skin characteristics and user satisfaction publication-title: Med. Dev. – volume: 97 start-page: 33 year: 2004 ident: 10.1016/j.ejpb.2013.08.008_b0100 article-title: Improvement of bacterial cellulose production by addition of agar in a jar fermentor publication-title: J. Biosci. Bioeng. doi: 10.1016/S1389-1723(04)70162-0 – volume: 27 start-page: 145 year: 2006 ident: 10.1016/j.ejpb.2013.08.008_b0010 article-title: Microbial cellulose – the natural power to heal wounds publication-title: Biomaterials doi: 10.1016/j.biomaterials.2005.07.035 – volume: 435 start-page: 83 year: 2012 ident: 10.1016/j.ejpb.2013.08.008_b0035 article-title: Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2012.01.002 – volume: 51 year: 2009 ident: 10.1016/j.ejpb.2013.08.008_b0055 article-title: In vivo and in vitro evaluation of an Acetobacter xylinum synthesized microbial cellulose membrane intended for guided tissue repair publication-title: Acta Vet. Scand. doi: 10.1186/1751-0147-51-12 – volume: 37 start-page: 53 year: 1997 ident: 10.1016/j.ejpb.2013.08.008_b0095 article-title: Guidelines on sodium lauryl sulfate (SLS) exposure tests. A report from the standardization group of the European society of contact dermatitis publication-title: Contact Dermatitis doi: 10.1111/j.1600-0536.1997.tb00041.x – volume: 12 start-page: 4162 year: 2011 ident: 10.1016/j.ejpb.2013.08.008_b0040 article-title: Biocellulose membranes as supports for dermal release of lidocaine publication-title: Biomacromolecules doi: 10.1021/bm201303r – volume: 10 start-page: 123 year: 1984 ident: 10.1016/j.ejpb.2013.08.008_b0075 article-title: Intraregional variation between contact irritant patch test sites publication-title: Contact Dermatitis doi: 10.1111/j.1600-0536.1984.tb00362.x – volume: 86 start-page: 1417 year: 2011 ident: 10.1016/j.ejpb.2013.08.008_b0020 article-title: Gluconacetobacter sacchari: an efficient bacterial cellulose cell-factory publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2011.06.046 – volume: 79 start-page: 418 year: 1999 ident: 10.1016/j.ejpb.2013.08.008_b0115 article-title: Glycerol accelerates recovery of barrier function in vivo publication-title: Acta Derm. Venereol. doi: 10.1080/000155599750009825 – volume: 8 start-page: 1 year: 2007 ident: 10.1016/j.ejpb.2013.08.008_b0025 article-title: The future prospects of microbial cellulose in biomedical applications publication-title: Biomacromolecules doi: 10.1021/bm060620d – volume: 26 start-page: 61 issue: Suppl. 3 year: 2012 ident: 10.1016/j.ejpb.2013.08.008_b0135 article-title: Adherence to topical treatment in psoriasis: a systematic literature review publication-title: J. Eur. Acad. Dermatol. Venereol. doi: 10.1111/j.1468-3083.2012.04525.x – volume: 21 start-page: 39 year: 2008 ident: 10.1016/j.ejpb.2013.08.008_b0130 article-title: Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation publication-title: Skin Pharmacol. Physiol. doi: 10.1159/000111134 – volume: 45 start-page: 286 year: 2001 ident: 10.1016/j.ejpb.2013.08.008_b0090 article-title: Which bioengineering assay is appropriate for irritant patch testing with sodium lauryl sulfate? publication-title: Contact Dermatitis doi: 10.1034/j.1600-0536.2001.450506.x – volume: 23 start-page: 115 year: 2001 ident: 10.1016/j.ejpb.2013.08.008_b0110 article-title: The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties publication-title: Int. J. Cosmet. Sci. doi: 10.1046/j.1467-2494.2001.00060.x – volume: 82 start-page: 45 year: 2002 ident: 10.1016/j.ejpb.2013.08.008_b0125 article-title: A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients publication-title: Acta Derm. Venereol. doi: 10.1080/000155502753600885 – volume: 7 start-page: 209 year: 2001 ident: 10.1016/j.ejpb.2013.08.008_b0120 article-title: Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis publication-title: Skin Res. Technol.: Off. J. Int. Soc. Bioeng. Skin doi: 10.1034/j.1600-0846.2001.070401.x |
| SSID | ssj0004758 |
| Score | 2.503895 |
| Snippet | Bacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 332 |
| SubjectTerms | Adult Bacteria Bacterial cellulose Cellulose - administration & dosage Cellulose - chemistry Drug delivery Drug Delivery Systems - methods Female Gluconacetobacter - chemistry Gluconoacetobacter sacchari Humans Male Skin - drug effects Skin - metabolism Skin compatibility Skin hydration Skin irritation Young Adult |
| Title | Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study |
| URI | https://dx.doi.org/10.1016/j.ejpb.2013.08.008 https://www.ncbi.nlm.nih.gov/pubmed/23973717 https://www.proquest.com/docview/1515647206 https://www.proquest.com/docview/1544000824 |
| Volume | 86 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9tAEF4huPSCSnk0lKKthHIBEzveeNfcAmqUtipCAiQkDqt9GSVNnChOkHLhtzPjtYmQ2hx6s62xtZrZxzfWN98QcuJSxZQJDSxxZQKU0Ap05jpBarNIsTgUJsJq5N_XSf-e_XzoPGyQq7oWBmmV1d7v9_Ryt66etCpvtqaDQesWcvE0YdgqHRMHjhXljHGc5ecvK5oH42WPTjQO0LoqnPEcLzecaqR3xaWMJ7aY_Pvh9C_wWR5CvY9ku0KPtOsHuEM2XP6JNG-8_PTyjN6tqqmKM9qkNyth6uUuebz00szwBfxfvxhNCkfHbgwJM2x4VBXUzhZP1LoRkjWW1Ks8Fxe0m9NBTp8HzxNa_IGrkrg-97xaMEOF2j1y3_t-d9UPquYKgWERnwcAfaw1pqOFbmfKmlBoOKx5CEGFHMsA8I5dwnUoLHcmtJFOU8cUgCedcRE7Fe-TzXySu8-ECrBybRVFLlZMs0yktq2SNOMuE5Dv8QaJaq9KUymPYwOMkawpZkOJkZAYCYldMUPRIKdv70y97sZa604dLPlu9kg4GNa-962OrIRlhb4Hh08WhUSch8r6YbLOhrESQ7EGOfDT4m2sbcB5MaTKh_85si_kA9xVHKEjsjmfLdxXgD9zfVzO72Oy1f3xq3_9Ch1dBaw |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEB7S9JBeStukifvcQsilUSxZa-2qtzQ0uM2DQB0I9LDsS8WpI5vIDvjS394ZrRQTaH3oTUgjsezsznwjvv0GYNfnmmsbW9zi2kYkoRWZwvej3BWJ5mksbUKnkc_Os8El_3bVv1qDo_YsDNEqm9gfYnodrZs73WY2u9PRqPsda_E849QqnQoHIR7BY47bl9oYHPxe8jy4qJt0knVE5s3JmUDy8tdTQ_yutNbxpB6Tf89O_0KfdRY6fgZPG_jIDsMIn8OaL1_A3kXQn17ss-HyOFW1z_bYxVKZerEJPz4HbWb8Av2wn48nlWc3_gYrZox4TFfM3c5_MufHxNZYsCDzXH1ihyUblexudDdh1S-8qpnrs0CsRTOSqN2Cy-Mvw6NB1HRXiCxPxCxC7OOctX0jTa_QzsbSYLYWMXoViyyLyDv1mTCxdMLb2CUmzz3XiJ5MIWTqdfoS1stJ6XeASbTyPZ0kPtXc8ELmrqezvBC-kFjwiQ4k7awq20iPUweMsWo5ZteKPKHIE4raYsayAx_v35kG4Y2V1v3WWerB8lGYGVa-96H1rMJ9RXOPEz6ZV4qAHknrx9kqG85rEMU7sB2Wxf1Yewj0UqyVX_3nyN7DxmB4dqpOv56fvIYn-KQhDL2B9dnt3L9FLDQz7-q1_gcBmgc6 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bacterial+cellulose+membranes+as+drug+delivery+systems%3A+An+in+vivo+skin+compatibility+study&rft.jtitle=European+journal+of+pharmaceutics+and+biopharmaceutics&rft.au=Almeida%2C+I+F&rft.au=Pereira%2C+T&rft.au=Silva%2C+NHCS&rft.au=Gomes%2C+F+P&rft.date=2014-04-01&rft.issn=0939-6411&rft.volume=86&rft.issue=3&rft.spage=332&rft.epage=336&rft_id=info:doi/10.1016%2Fj.ejpb.2013.08.008&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0939-6411&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0939-6411&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0939-6411&client=summon |