Two-group classification of patients with obstructive sleep apnea based on analysis of brain recurrence
Highlights • The severity of obstructive sleep apnea (OSA) was directly reflected in the sleep EEG. • Binary classification of patients with OSA (mild or moderate) was achieved by analyzing the EEG from one derivation. • Analysis of brain recurrence is an effective algorithmic technique for extracti...
Saved in:
| Published in | Clinical neurophysiology Vol. 125; no. 6; pp. 1174 - 1181 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ireland Ltd
01.06.2014
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Highlights • The severity of obstructive sleep apnea (OSA) was directly reflected in the sleep EEG. • Binary classification of patients with OSA (mild or moderate) was achieved by analyzing the EEG from one derivation. • Analysis of brain recurrence is an effective algorithmic technique for extracting useful diagnostic information regarding OSA from the EEG. |
|---|---|
| AbstractList | Highlights • The severity of obstructive sleep apnea (OSA) was directly reflected in the sleep EEG. • Binary classification of patients with OSA (mild or moderate) was achieved by analyzing the EEG from one derivation. • Analysis of brain recurrence is an effective algorithmic technique for extracting useful diagnostic information regarding OSA from the EEG. To demonstrate that the severity of obstructive sleep apnea (OSA) could be predicted algorithmically by means of recurrence analysis of the sleep-staged electroencephalogram (EEG). A randomly selected cohort of 20 sleep-staged patients with OSA (apnea-hypopnea index (AHI) 5-30) was divided into mild and moderate sub-cohorts (AHI 5-15, 16-30, respectively), and the sleep EEG (C3) was analyzed using analysis of brain recurrence (ABR) (LSU cohort). Twenty distinct but related markers for sleep depth and fragmentation were computed from four ABR variables, and a marker function capable of classifying each patient into one of the two sub-cohorts was determined by linear discriminant analysis. Classification accuracy of individual patients was evaluated using area under the receiver operator characteristics curve (AUROC). As a control procedure, 20 additional sleep-staged patients with OSA whose polysomnographic data was obtained from an independent database were also evaluated (SHHS cohort). On average, markers for sleep depth were reduced and those for sleep fragmentation were increased in the patients with moderate OSA, as expected. All patients in both cohorts were correctly classified using as few as 5-6 markers. The degree of severity of OSA was reflected in objective changes in the sleep EEG. Recurrence analysis of the EEG potentially has uses beyond identification of the degree of OSA. •The severity of obstructive sleep apnea (OSA) was directly reflected in the sleep EEG.•Binary classification of patients with OSA (mild or moderate) was achieved by analyzing the EEG from one derivation.•Analysis of brain recurrence is an effective algorithmic technique for extracting useful diagnostic information regarding OSA from the EEG. To demonstrate that the severity of obstructive sleep apnea (OSA) could be predicted algorithmically by means of recurrence analysis of the sleep-staged electroencephalogram (EEG). A randomly selected cohort of 20 sleep-staged patients with OSA (apnea–hypopnea index (AHI) 5–30) was divided into mild and moderate sub-cohorts (AHI 5–15, 16–30, respectively), and the sleep EEG (C3) was analyzed using analysis of brain recurrence (ABR) (LSU cohort). Twenty distinct but related markers for sleep depth and fragmentation were computed from four ABR variables, and a marker function capable of classifying each patient into one of the two sub-cohorts was determined by linear discriminant analysis. Classification accuracy of individual patients was evaluated using area under the receiver operator characteristics curve (AUROC). As a control procedure, 20 additional sleep-staged patients with OSA whose polysomnographic data was obtained from an independent database were also evaluated (SHHS cohort). On average, markers for sleep depth were reduced and those for sleep fragmentation were increased in the patients with moderate OSA, as expected. All patients in both cohorts were correctly classified using as few as 5–6 markers. The degree of severity of OSA was reflected in objective changes in the sleep EEG. Recurrence analysis of the EEG potentially has uses beyond identification of the degree of OSA. OBJECTIVETo demonstrate that the severity of obstructive sleep apnea (OSA) could be predicted algorithmically by means of recurrence analysis of the sleep-staged electroencephalogram (EEG).METHODSA randomly selected cohort of 20 sleep-staged patients with OSA (apnea-hypopnea index (AHI) 5-30) was divided into mild and moderate sub-cohorts (AHI 5-15, 16-30, respectively), and the sleep EEG (C3) was analyzed using analysis of brain recurrence (ABR) (LSU cohort). Twenty distinct but related markers for sleep depth and fragmentation were computed from four ABR variables, and a marker function capable of classifying each patient into one of the two sub-cohorts was determined by linear discriminant analysis. Classification accuracy of individual patients was evaluated using area under the receiver operator characteristics curve (AUROC). As a control procedure, 20 additional sleep-staged patients with OSA whose polysomnographic data was obtained from an independent database were also evaluated (SHHS cohort).RESULTSOn average, markers for sleep depth were reduced and those for sleep fragmentation were increased in the patients with moderate OSA, as expected. All patients in both cohorts were correctly classified using as few as 5-6 markers.SIGNIFICANCEThe degree of severity of OSA was reflected in objective changes in the sleep EEG. Recurrence analysis of the EEG potentially has uses beyond identification of the degree of OSA. |
| Author | Wang, Lei Marino, Andrew A Kim, Paul Y Frilot, Clifton McCarty, David E Chesson, Andrew L |
| Author_xml | – sequence: 1 fullname: Kim, Paul Y – sequence: 2 fullname: McCarty, David E – sequence: 3 fullname: Wang, Lei – sequence: 4 fullname: Frilot, Clifton – sequence: 5 fullname: Chesson, Andrew L – sequence: 6 fullname: Marino, Andrew A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24290851$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUtv1TAQhS1URB_wDxDykk1Sjx9NskFCFS-pEgvK2nKcSetLrh08Sav773F0Cws2Xc0szjmj-c45O4kpImNvQdQg4OpyV_spxPm-lgJUDVALIV-wM2gbWbWdkSdlV21bSW2aU3ZOtBNCNELLV-xUatmJ1sAZu7t9TNVdTuvM_eSIwhi8W0KKPI18LhvGhfhjWO556mnJq1_CA3KaEGfu5oiO945w4MXhopsOFGiz9tmFyDP6NWeMHl-zl6ObCN88zQv28_On2-uv1c33L9-uP95UXkOzVBJGNH2jlOk6Cbq9Mt5LNKMf-2FsjTCNlCiHEXvVozJ9h86pxms_aNCDQXXB3h9z55x-r0iL3QfyOE0uYlrJgpG6hUa2pkj1UepzIso42jmHvcsHC8JuiO3OHhHbDbEFsAVxsb17urD2exz-mf4yLYIPRwGWPx8CZks-bAyGUHgsdkjhuQv_B2yi0sv0Cw9Iu7TmQrr8YklaYX9sNW8tgxIADYD6A8EXp4A |
| CitedBy_id | crossref_primary_10_1159_000441975 crossref_primary_10_1016_j_jneumeth_2018_07_017 crossref_primary_10_1109_TNSRE_2022_3224474 |
| Cites_doi | 10.1016/B978-0-444-53817-8.00003-7 10.1016/j.pcad.2008.10.005 10.1016/j.jns.2013.04.019 10.1016/j.neuroimage.2010.09.065 10.1161/CIRCULATIONAHA.105.556746 10.5665/sleep.2620 10.1016/j.jneumeth.2012.04.018 10.1159/000325109 10.1016/j.jneumeth.2008.05.008 10.1179/1743132812Y.0000000010 10.1046/j.1365-2869.1997.00029.x 10.1007/s00408-011-9340-1 |
| ContentType | Journal Article |
| Copyright | International Federation of Clinical Neurophysiology 2013 International Federation of Clinical Neurophysiology Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
| Copyright_xml | – notice: International Federation of Clinical Neurophysiology – notice: 2013 International Federation of Clinical Neurophysiology – notice: Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.clinph.2013.11.002 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1872-8952 |
| EndPage | 1181 |
| ExternalDocumentID | 10_1016_j_clinph_2013_11_002 24290851 S1388245713011711 1_s2_0_S1388245713011711 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M -~X .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29B 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ AABNK AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXKI AAXLA AAXUO ABBQC ABCQJ ABFNM ABFRF ABIVO ABJNI ABLJU ABMAC ABMZM ABTEW ABXDB ACDAQ ACGFO ACIUM ACRLP ADBBV ADEZE ADMUD ADVLN AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFJKZ AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AI. AIEXJ AIKHN AITUG AJOXV AJRQY AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HX~ HZ~ IHE J1W K-O KOM L7B M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OHT OP~ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSN SSZ T5K UAP UNMZH UV1 VH1 VQA X7M XOL XPP Z5R ZGI ~G- AADPK AAIAV ABLVK ABYKQ AFMIJ AHPSJ AJBFU EFLBG LCYCR ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c417t-21fe5b733599214865cc2e5fcfbdf8505722e2dfeb3be35b9eaa37c4cd414d5e3 |
| IEDL.DBID | .~1 |
| ISSN | 1388-2457 |
| IngestDate | Sat Oct 05 04:41:21 EDT 2024 Thu Sep 26 18:19:47 EDT 2024 Sat Sep 28 07:53:56 EDT 2024 Fri Feb 23 02:20:39 EST 2024 Tue Oct 15 22:57:37 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Biomarkers Sleep fragmentation Linear discrimination analysis Brain recurrence analysis Obstructive sleep apnea Sleep depth |
| Language | English |
| License | Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c417t-21fe5b733599214865cc2e5fcfbdf8505722e2dfeb3be35b9eaa37c4cd414d5e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 24290851 |
| PQID | 1524817285 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1524817285 crossref_primary_10_1016_j_clinph_2013_11_002 pubmed_primary_24290851 elsevier_sciencedirect_doi_10_1016_j_clinph_2013_11_002 elsevier_clinicalkeyesjournals_1_s2_0_S1388245713011711 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-06-01 |
| PublicationDateYYYYMMDD | 2014-06-01 |
| PublicationDate_xml | – month: 06 year: 2014 text: 2014-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Clinical neurophysiology |
| PublicationTitleAlternate | Clin Neurophysiol |
| PublicationYear | 2014 |
| Publisher | Elsevier Ireland Ltd |
| Publisher_xml | – name: Elsevier Ireland Ltd |
| References | Carrubba, Minagar, Chesson, Frilot II, Marino (b0025) 2011; 34 Wang, Kim, Mccarty, Frilot II, Chesson, Carrubba (b0080) 2013; 331 Zhang, Wang, Qin, Li, Chen, Zhang (b0090) 2013; 36 Jackson, Howard, Barnes (b0040) 2011; 190 Fietze, Quispe-Bravo, Hänsch, Röttig, Baumann, Witt (b0030) 1997; 6 Lurie (b0045) 2011; 46 Quan, Howard, Iber, Kiley, Nieto, O’connor (b0060) 1997; 20 American Academy of Sleep Medicine (b0010) 2012 Torelli, Moscufo, Garreffa, Placidi, Romigi, Zannino (b0075) 2011; 54 . National Heart Lung & Blood Institute. Sleep heart health study. 2012 [Updated 24 Apr 2012; Cited 2013 Jan 11]; Available from Carrubba, Kim, Mccarty, Chesson, Frilot, Marino (b0020) 2012; 208 McNichols (b0050) 2009; 51 American Academy of Sleep Medicine (b0005) 2007 Golbidi, Badran, Ayas, Laher (b0035) 2012; 190 Zbilut, Webber (b0085) 2006 Ryan, Taylor, McNicholas (b0065) 2005; 112 Theodoridis, Koutroumbas (b0070) 2008 Carrubba, Frilot II, Chesson, Marino (b0015) 2008; 173 Theodoridis (10.1016/j.clinph.2013.11.002_b0070) 2008 Carrubba (10.1016/j.clinph.2013.11.002_b0025) 2011; 34 Quan (10.1016/j.clinph.2013.11.002_b0060) 1997; 20 Golbidi (10.1016/j.clinph.2013.11.002_b0035) 2012; 190 Zhang (10.1016/j.clinph.2013.11.002_b0090) 2013; 36 Lurie (10.1016/j.clinph.2013.11.002_b0045) 2011; 46 Jackson (10.1016/j.clinph.2013.11.002_b0040) 2011; 190 Wang (10.1016/j.clinph.2013.11.002_b0080) 2013; 331 Carrubba (10.1016/j.clinph.2013.11.002_b0015) 2008; 173 McNichols (10.1016/j.clinph.2013.11.002_b0050) 2009; 51 10.1016/j.clinph.2013.11.002_b0055 American Academy of Sleep Medicine (10.1016/j.clinph.2013.11.002_b0010) 2012 Zbilut (10.1016/j.clinph.2013.11.002_b0085) 2006 Ryan (10.1016/j.clinph.2013.11.002_b0065) 2005; 112 Fietze (10.1016/j.clinph.2013.11.002_b0030) 1997; 6 Carrubba (10.1016/j.clinph.2013.11.002_b0020) 2012; 208 American Academy of Sleep Medicine (10.1016/j.clinph.2013.11.002_b0005) 2007 Torelli (10.1016/j.clinph.2013.11.002_b0075) 2011; 54 |
| References_xml | – volume: 173 start-page: 41 year: 2008 end-page: 46 ident: b0015 article-title: Method for detection of changes in the EEG induced by the presence of sensory stimuli publication-title: J Neurosci Meth contributor: fullname: Marino – year: 2008 ident: b0070 article-title: Pattern recognition contributor: fullname: Koutroumbas – volume: 54 start-page: 787 year: 2011 end-page: 793 ident: b0075 article-title: Cognitive profile and brain morphological changes in obstructive sleep apnea publication-title: Neuroimage contributor: fullname: Zannino – year: 2007 ident: b0005 article-title: The AASM manual for the scoring of sleep and associated events: rules terminology and technical specifications contributor: fullname: American Academy of Sleep Medicine – volume: 20 start-page: 1077 year: 1997 end-page: 1085 ident: b0060 article-title: The sleep heart health study: design, rationale, and methods publication-title: Sleep contributor: fullname: O’connor – volume: 190 start-page: 113 year: 2012 end-page: 132 ident: b0035 article-title: Cardiovascular consequences of sleep apnea publication-title: Lung contributor: fullname: Laher – volume: 6 start-page: 128 year: 1997 end-page: 133 ident: b0030 article-title: Arousals and sleep stages in patients with obstructive sleep apnoea syndrome: changes under NCPAP treatment publication-title: J Sleep Res contributor: fullname: Witt – volume: 36 start-page: 651b year: 2013 end-page: 659b ident: b0090 article-title: Altered resting-stage brain activity in obstructive sleep apnea publication-title: Sleep contributor: fullname: Zhang – year: 2012 ident: b0010 article-title: The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications (Version 2.0) contributor: fullname: American Academy of Sleep Medicine – volume: 34 start-page: 286 year: 2011 end-page: 290 ident: b0025 article-title: Increased determinism in brain electrical activity occurs in association with multiple sclerosis publication-title: Neurol Res contributor: fullname: Marino – start-page: 2979 year: 2006 end-page: 2986 ident: b0085 article-title: Recurrence quantification analysis publication-title: Wiley encyclopedia of biomedical engineering contributor: fullname: Webber – volume: 46 start-page: 171 year: 2011 end-page: 195 ident: b0045 article-title: Hemodynamic and autonomic changes in adults with obstructive sleep apnea publication-title: Adv Cardiol contributor: fullname: Lurie – volume: 208 start-page: 1 year: 2012 end-page: 9 ident: b0020 article-title: Continuous EEG-based dynamic markers for sleep depth and phasic events publication-title: J Neurosci Meth contributor: fullname: Marino – volume: 190 start-page: 53 year: 2011 end-page: 68 ident: b0040 article-title: Cognition and daytime functioning in sleep-related breathing disorders publication-title: Prog Brain Res contributor: fullname: Barnes – volume: 112 start-page: 2660 year: 2005 end-page: 2667 ident: b0065 article-title: Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome publication-title: Circulation contributor: fullname: McNicholas – volume: 51 start-page: 392 year: 2009 end-page: 399 ident: b0050 article-title: Obstructive sleep apnea and inflammation publication-title: Prog Cardiovasc Dis contributor: fullname: McNichols – volume: 331 start-page: 26 year: 2013 end-page: 30 ident: b0080 article-title: EEG recurrence markers and sleep quality publication-title: J Neurol Sci contributor: fullname: Carrubba – volume: 190 start-page: 53 year: 2011 ident: 10.1016/j.clinph.2013.11.002_b0040 article-title: Cognition and daytime functioning in sleep-related breathing disorders publication-title: Prog Brain Res doi: 10.1016/B978-0-444-53817-8.00003-7 contributor: fullname: Jackson – year: 2012 ident: 10.1016/j.clinph.2013.11.002_b0010 contributor: fullname: American Academy of Sleep Medicine – volume: 51 start-page: 392 year: 2009 ident: 10.1016/j.clinph.2013.11.002_b0050 article-title: Obstructive sleep apnea and inflammation publication-title: Prog Cardiovasc Dis doi: 10.1016/j.pcad.2008.10.005 contributor: fullname: McNichols – volume: 331 start-page: 26 year: 2013 ident: 10.1016/j.clinph.2013.11.002_b0080 article-title: EEG recurrence markers and sleep quality publication-title: J Neurol Sci doi: 10.1016/j.jns.2013.04.019 contributor: fullname: Wang – volume: 54 start-page: 787 year: 2011 ident: 10.1016/j.clinph.2013.11.002_b0075 article-title: Cognitive profile and brain morphological changes in obstructive sleep apnea publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.09.065 contributor: fullname: Torelli – volume: 112 start-page: 2660 year: 2005 ident: 10.1016/j.clinph.2013.11.002_b0065 article-title: Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.556746 contributor: fullname: Ryan – volume: 36 start-page: 651b year: 2013 ident: 10.1016/j.clinph.2013.11.002_b0090 article-title: Altered resting-stage brain activity in obstructive sleep apnea publication-title: Sleep doi: 10.5665/sleep.2620 contributor: fullname: Zhang – volume: 20 start-page: 1077 year: 1997 ident: 10.1016/j.clinph.2013.11.002_b0060 article-title: The sleep heart health study: design, rationale, and methods publication-title: Sleep contributor: fullname: Quan – ident: 10.1016/j.clinph.2013.11.002_b0055 – volume: 208 start-page: 1 year: 2012 ident: 10.1016/j.clinph.2013.11.002_b0020 article-title: Continuous EEG-based dynamic markers for sleep depth and phasic events publication-title: J Neurosci Meth doi: 10.1016/j.jneumeth.2012.04.018 contributor: fullname: Carrubba – volume: 46 start-page: 171 year: 2011 ident: 10.1016/j.clinph.2013.11.002_b0045 article-title: Hemodynamic and autonomic changes in adults with obstructive sleep apnea publication-title: Adv Cardiol doi: 10.1159/000325109 contributor: fullname: Lurie – start-page: 2979 year: 2006 ident: 10.1016/j.clinph.2013.11.002_b0085 article-title: Recurrence quantification analysis contributor: fullname: Zbilut – volume: 173 start-page: 41 year: 2008 ident: 10.1016/j.clinph.2013.11.002_b0015 article-title: Method for detection of changes in the EEG induced by the presence of sensory stimuli publication-title: J Neurosci Meth doi: 10.1016/j.jneumeth.2008.05.008 contributor: fullname: Carrubba – year: 2007 ident: 10.1016/j.clinph.2013.11.002_b0005 contributor: fullname: American Academy of Sleep Medicine – volume: 34 start-page: 286 year: 2011 ident: 10.1016/j.clinph.2013.11.002_b0025 article-title: Increased determinism in brain electrical activity occurs in association with multiple sclerosis publication-title: Neurol Res doi: 10.1179/1743132812Y.0000000010 contributor: fullname: Carrubba – year: 2008 ident: 10.1016/j.clinph.2013.11.002_b0070 contributor: fullname: Theodoridis – volume: 6 start-page: 128 year: 1997 ident: 10.1016/j.clinph.2013.11.002_b0030 article-title: Arousals and sleep stages in patients with obstructive sleep apnoea syndrome: changes under NCPAP treatment publication-title: J Sleep Res doi: 10.1046/j.1365-2869.1997.00029.x contributor: fullname: Fietze – volume: 190 start-page: 113 year: 2012 ident: 10.1016/j.clinph.2013.11.002_b0035 article-title: Cardiovascular consequences of sleep apnea publication-title: Lung doi: 10.1007/s00408-011-9340-1 contributor: fullname: Golbidi |
| SSID | ssj0007042 |
| Score | 2.1727557 |
| Snippet | Highlights • The severity of obstructive sleep apnea (OSA) was directly reflected in the sleep EEG. • Binary classification of patients with OSA (mild or... •The severity of obstructive sleep apnea (OSA) was directly reflected in the sleep EEG.•Binary classification of patients with OSA (mild or moderate) was... To demonstrate that the severity of obstructive sleep apnea (OSA) could be predicted algorithmically by means of recurrence analysis of the sleep-staged... OBJECTIVETo demonstrate that the severity of obstructive sleep apnea (OSA) could be predicted algorithmically by means of recurrence analysis of the... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1174 |
| SubjectTerms | Algorithms Area Under Curve Biomarkers Brain recurrence analysis Cohort Studies Electroencephalography Female Humans Linear discrimination analysis Male Middle Aged Neurology Obstructive sleep apnea Polysomnography - methods ROC Curve Sleep Apnea, Obstructive - classification Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - physiopathology Sleep Deprivation - complications Sleep Deprivation - diagnosis Sleep Deprivation - physiopathology Sleep depth Sleep fragmentation Sleep Stages - physiology |
| Title | Two-group classification of patients with obstructive sleep apnea based on analysis of brain recurrence |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S1388245713011711 https://dx.doi.org/10.1016/j.clinph.2013.11.002 https://www.ncbi.nlm.nih.gov/pubmed/24290851 https://search.proquest.com/docview/1524817285 |
| Volume | 125 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NSx0xEA-iIL0UtV-vVUmh1_je5mM_jiLKs0UvKngLyWa2WMru4qq9-bd3JpvVSi1Cj7skZHcmmflNMr8JY18WUKsiKCmyspBCQ8hE6auFAB2qRpXe5YaIwien-fJCf700lyvsYOLCUFplsv2jTY_WOr2ZJ2nO-6ur-VmmEB1qg1EW1TWL_F6N7g_n9N79Y5pHsYgX6FBjQa0n-lzM8SL2YU9HEpnao1qeaXPlGff0L_gZ3dDRBnud8CPfHz9xk61Au8XWT9IJ-Rv2_fxXJyJVg9cEjCkTKAqfdw1PRVQHTruvvPOpeOwd8OEnQM9d34Lj5NgCxx4uFSyhrp6ukuDXtDsf-YFv2cXR4fnBUqTLFESts-JGyKwB4wulTFVJjIFyU9cSTFM3PjQlhSlSggwNBtcelPEVOKeKWtdBZzoYUO_Yatu18IFx7UqfBxcQehFNVlYNqtUhksqDKvMinzExydD2Y80MOyWT_bCjzC3JHMMPizKfsWIStJ34oGjBYEjLabCZHaRd2L9U_mfPJ7PGokN4YczPk0YtLig6JXEtdLc4lpG6pFu7zIy9H1X98BeIZyrCqB__e9xP7BU-6THZbJutop5hB2HNjd-N83aXre0ff1ue_gbCD_eR |
| link.rule.ids | 315,783,787,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYQSNBLVeiDbQu4Eld3N37kcUSoaHnsXlgkbpYdTyoQSqKGtn-_M4mDigqqxDXJyMlMPPONPd-YscMZlCoLSookz6TQEBKR-2ImQIeiUrl3qSGi8GKZzq_02bW5XmPHIxeGyiqj7x98eu-t45Vp1Oa0vbmZXiYK0aE2mGVRXzPi924gGihwdm4cnZ7Plw8OOZv1Z-jQ84IERgZdX-ZFBMSWdiUS9ZXaecb1lSci1HMItI9EJ2_Y6wgh-dHwlttsDeodtrmIm-Rv2ffV70b0bA1eEjamYqBe_7ypeOyj2nFagOWNj_1jfwHv7gBa7toaHKfYFjhKuNizhEQ9nSbBf9ACfU8RfMeuTr6tjucinqcgSp1k90ImFRifKWWKQmIalJqylGCqsvKhyilTkRJkqDC_9qCML8A5lZW6DDrRwYB6z9brpoZdxrXLfRpcQPRFTFlZVGhZh2AqDSpPs3TCxKhD2w5tM-xYT3ZrB51b0jlmIBZ1PmHZqGg7UkLRiUEXZ1RnE9tJO7P_WP1vyUc_jsWY8J8xv4wWtTinaKPE1dD8xLGM1Dkd3GUm7MNg6oevQEhTEEz9-OJxD9jWfLW4sBeny_NP7BXe0UPt2We2jjaHPUQ5934__sV_AEQo-kU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Two-group+classification+of+patients+with+obstructive+sleep+apnea+based+on+analysis+of+brain+recurrence&rft.jtitle=Clinical+neurophysiology&rft.au=Kim%2C+Paul+Y&rft.au=McCarty%2C+David+E&rft.au=Wang%2C+Lei&rft.au=Frilot%2C+Clifton&rft.date=2014-06-01&rft.issn=1388-2457&rft.volume=125&rft.issue=6&rft.spage=1174&rft.epage=1181&rft_id=info:doi/10.1016%2Fj.clinph.2013.11.002&rft.externalDBID=ECK1-s2.0-S1388245713011711&rft.externalDocID=1_s2_0_S1388245713011711 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F13882457%2FS1388245714X00052%2Fcov150h.gif |