Persistence of multiply antibiotic-resistant campylobacter jejuni in a patient with the acquired immune deficiency syndrome

Chronic diarrhea due to Campylobacter jejuni has been described in patients with hypogammaglobulinemia. A patient with the acquired immune deficiency syndrome (AIDS) and normal total serum immunoglobulins had persistent diarrhea and C. jejuni on stool culture for seven and a half months despite repe...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of medicine Vol. 80; no. 5; pp. 965 - 970
Main Authors Dworkin, Brad, Wormser, Gary P., Abdoo, Robert A., Cabello, Felipe, Aguero, Maria E., Sivak, Steven L.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.05.1986
Elsevier
Subjects
Acquired Immunodeficiency Syndrome - microbiology
Adult
AIDS/HIV
Biological and medical sciences
Campylobacter fetus - drug effects
Campylobacter fetus - isolation & purification
Campylobacter Infections - microbiology
Campylobacter jejuni
Chronic Disease
Diarrhea - microbiology
Drug Resistance, Microbial
Feces - microbiology
Female
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Medical sciences
Microbial Sensitivity Tests
Infection
Campylobacter infection
Immunopathology
Spirillales
Bacteriosis
Spirillaceae
Diarrhea
Bacteria
Digestive diseases
AIDS
Intestinal disease
Campylobacter jejuni
Online AccessGet full text

Cover

More Information
Summary:Chronic diarrhea due to Campylobacter jejuni has been described in patients with hypogammaglobulinemia. A patient with the acquired immune deficiency syndrome (AIDS) and normal total serum immunoglobulins had persistent diarrhea and C. jejuni on stool culture for seven and a half months despite repeated antibiotic therapy. Antibiotic sensitivity studies revealed the C. jejuni to be multiply antibiotic-resistant. Evaluation of the mechanism of resistance showed the organism harbored a conjugative plasmid capable of transferring resistance to tetracycline, but not to other antibiotics. It is concluded that C. jejuni infection may rarely result in chronic diarrhea in patients with AIDS. The combination of an immune deficiency state including abnormal B cell function previously described in AIDS and multiple antibiotic resistance may have contributed to the persistence of the organism in this case.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Case Study-3
ObjectType-Article-1
ObjectType-Feature-4
ObjectType-Report-2
ISSN:0002-9343
1555-7162
DOI:10.1016/0002-9343(86)90646-7