A Higher Frequency of NKG2A + than of NKG2A − NK Cells Responds to Autologous HIV-Infected CD4 Cells irrespective of Whether or Not They Coexpress KIR3DL1

• Published in: Journal of virology Vol. 89; no. 19; pp. 9909 - 9919
• Main Authors: Lisovsky, Irene, Isitman, Gamze, Song, Rujun, DaFonseca, Sandrina, Tremblay-McLean, Alexandra, Lebouché, Bertrand, Routy, Jean-Pierre, Bruneau, Julie, Bernard, Nicole F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.10.2015
• Subjects: Autoantigens; CD4-Positive T-Lymphocytes - immunology; HIV Infections - genetics; HIV Infections - immunology; HIV-1; HLA Antigens - genetics; Homozygote; Host-Pathogen Interactions - immunology; Human immunodeficiency virus; Humans; In Vitro Techniques; K562 Cells; Killer Cells, Natural - classification; Killer Cells, Natural - immunology; Ligands; NK Cell Lectin-Like Receptor Subfamily C - deficiency; NK Cell Lectin-Like Receptor Subfamily C - genetics; NK Cell Lectin-Like Receptor Subfamily C - metabolism; Pathogenesis and Immunity; Receptors, KIR3DL1 - deficiency; Receptors, KIR3DL1 - genetics; Receptors, KIR3DL1 - metabolism

Epidemiological and functional studies implicate NK cells in HIV control. However, there is little information available on which NK cell populations, as defined by the inhibitory NK cell receptors (iNKRs) they express, respond to autologous HIV-infected CD4 + (iCD4) T cells. NK cells acquire antivi...