Frank Stinchfield Award: Identification of the At-risk Genotype for Development of Pseudotumors Around Metal-on-metal THAs

• Published in: Clinical orthopaedics and related research Vol. 476; no. 2; pp. 230 - 241
• Main Authors: Kilb, Brett K. J., Kurmis, Andrew P., Parry, Michael, Sherwood, Karen, Keown, Paul, Masri, Bassam A., Duncan, Clive P., Garbuz, Donald S.
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.02.2018
• Subjects: Aged; Arthroplasty, Replacement, Hip - adverse effects; Arthroplasty, Replacement, Hip - instrumentation; British Columbia - epidemiology; Case-Control Studies; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Granuloma, Plasma Cell - epidemiology; Granuloma, Plasma Cell - genetics; Granuloma, Plasma Cell - immunology; Granuloma, Plasma Cell - surgery; Hip Joint - physiopathology; Hip Joint - surgery; Hip Prosthesis; Histocompatibility Antigens Class II - genetics; Histocompatibility Antigens Class II - immunology; Humans; Male; Metal-on-Metal Joint Prostheses; Middle Aged; Prevalence; Prosthesis Design; Prosthesis Failure; Reoperation; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; British Columbia

Once touted as the future of hip arthroplasty, metal-on-metal (MoM) bearing surfaces have fallen sharply from favor with the emergence of a strong body of evidence demonstrating unacceptably high premature implant failure rates. The previously unpredictable development of adverse local tissue reacti...