beta-Funaltrexamine (beta-FNA) and neural tumor response in mice

• Published in: European journal of pharmacology Vol. 116; no. 1-2; p. 165
• Main Authors: Zagon, I S, McLaughlin, P J, Takemori, A E, Portoghese, P S
• Format: Journal Article
• Language: English
• Published: Netherlands 08.10.1985
• Subjects: Animals; Male; Mice; Mice, Inbred A; Morphine - pharmacology; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Narcotic Antagonists - pharmacology; Neoplasm Transplantation; Neuroblastoma - pathology; Neuroblastoma - physiopathology; Reaction Time - drug effects

The effects of beta-FNA, a highly selective and irreversible mu opioid receptor antagonist, in altering tumor response in A/Jax mice inoculated with S20Y cells were determined. Inoculation of neuroblastoma cells in control subjects resulted in 100% tumor incidence within 16 days, and mean and median...