Experience of Pandemic Influenza with H1N1 in Children with Leukemia
It is not exactly known the risks from infection with pandemic influenza (H1N1) 2009 in children with leukemia. Here the authors present their experience in 5 children with leukemia. Pandemic influenza (H1N1) 2009 was detected in 5 patients (F/M: 3/2) at their institution. The ages of these patients...
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Published in | Pediatric hematology and oncology Vol. 28; no. 1; pp. 31 - 36 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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England
Informa Healthcare
01.02.2011
Taylor & Francis |
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Abstract | It is not exactly known the risks from infection with pandemic influenza (H1N1) 2009 in children with leukemia. Here the authors present their experience in 5 children with leukemia. Pandemic influenza (H1N1) 2009 was detected in 5 patients (F/M: 3/2) at their institution. The ages of these patients were between 2 and 16 years. Four had acute lymphoblastic leukemia (ALL) and 1 acute myeloblasic leukemia (AML). Three of the ALL patients had the diagnosis of pandemic influenza (H1N1) 2009 at the same time as they were diagnosed with ALL. The remaining 2 patients were receiving intensive chemotherapy. All patients had fever, rhinorrhea, and cough. Although bronchopneumonia was seen in 3 patients, only 1 revealed respiratory distress. Stomachache and diarrhea was seen in the patient who had no pneumonia. All treated as inpatients, but none of them required hospitalization in intensive care unit. One to 3 days after the symptoms of influenza appeared, oseltamivir (Tamiflu) was given to all patients in combination with broad-spectrum antibiotics. Fever declined to normal ranges in 1 to 3 days after treatment was started. The patients received oseltamivir for 5 to 7 days. Cell culture tests were found to be positive for influenza A and polymerase chain reaction (PCR) revealed H1N1 for all 5 patients. Although this is a very small case series, pandemic influenza (H1N1) 2009 did not seem to be very dangerous for children with leukemia if the oseltamivir treatment was given early when symptoms of influenza appeared. |
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AbstractList | It is not exactly known the risks from infection with pandemic influenza (H1N1) 2009 in children with leukemia. Here the authors present their experience in 5 children with leukemia. Pandemic influenza (H1N1) 2009 was detected in 5 patients (F/M: 3/2) at their institution. The ages of these patients were between 2 and 16 years. Four had acute lymphoblastic leukemia (ALL) and 1 acute myeloblasic leukemia (AML). Three of the ALL patients had the diagnosis of pandemic influenza (H1N1) 2009 at the same time as they were diagnosed with ALL. The remaining 2 patients were receiving intensive chemotherapy. All patients had fever, rhinorrhea, and cough. Although bronchopneumonia was seen in 3 patients, only 1 revealed respiratory distress. Stomachache and diarrhea was seen in the patient who had no pneumonia. All treated as inpatients, but none of them required hospitalization in intensive care unit. One to 3 days after the symptoms of influenza appeared, oseltamivir (Tamiflu) was given to all patients in combination with broad-spectrum antibiotics. Fever declined to normal ranges in 1 to 3 days after treatment was started. The patients received oseltamivir for 5 to 7 days. Cell culture tests were found to be positive for influenza A and polymerase chain reaction (PCR) revealed H1N1 for all 5 patients. Although this is a very small case series, pandemic influenza (H1N1) 2009 did not seem to be very dangerous for children with leukemia if the oseltamivir treatment was given early when symptoms of influenza appeared. It is not exactly known the risks from infection with pandemic influenza (H1N1) 2009 in children with leukemia. Here the authors present their experience in 5 children with leukemia. Pandemic influenza (H1N1) 2009 was detected in 5 patients (F/M: 3/2) at their institution. The ages of these patients were between 2 and 16 years. Four had acute lymphoblastic leukemia (ALL) and 1 acute myeloblastic leukemia (AML). Three of the ALL patients had the diagnosis of pandemic influenza (H1N1) 2009 at the same time as they were diagnosed with ALL. The remaining 2 patients were receiving intensive chemotherapy. All patients had fever, rhinorrhea, and cough. Although bronchopneumonia was seen in 3 patients, only 1 revealed respiratory distress. Stomach ache and diarrhea was seen in the patient who had no pneumonia. All treated as inpatients, but none of them required hospitalization in intensive care unit. One to 3 days after the symptoms of influenza appeared, oseltamivir (Tamiflu) was given to all patients in combination with broad-spectrum antibiotics. Fever declined to normal ranges in 1 to 3 days after treatment was started. The patients received oseltamivir for 5 to 7 days. Cell culture tests were found to be positive for influenza A and polymerase chain reaction (PCR) revealed H1N1 for all 5 patients. Although this is a very small case series, pandemic influenza (H1N1) 2009 did not seem to be very dangerous for children with leukemia if the oseltamivir treatment was given early when symptoms of influenza appeared. |
Author | Karzao lu, Zeynep Balkan, Can Ay, Y lmaz Karapinar, Deniz Yilmaz Vardar, Fad l Ergin, F rat Kavakli, Kaan |
Author_xml | – sequence: 1 givenname: Deniz Yilmaz surname: Karapinar fullname: Karapinar, Deniz Yilmaz email: dyilmazk@yahoo.com, dyilmazk@yahoo.com organization: 1Department of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey – sequence: 2 givenname: Y lmaz surname: Ay fullname: Ay, Y lmaz email: dyilmazk@yahoo.com, dyilmazk@yahoo.com organization: 1Department of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey – sequence: 3 givenname: Zeynep surname: Karzao lu fullname: Karzao lu, Zeynep email: dyilmazk@yahoo.com, dyilmazk@yahoo.com organization: 1Department of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey – sequence: 4 givenname: Can surname: Balkan fullname: Balkan, Can email: dyilmazk@yahoo.com, dyilmazk@yahoo.com organization: 1Department of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey – sequence: 5 givenname: F rat surname: Ergin fullname: Ergin, F rat email: dyilmazk@yahoo.com, dyilmazk@yahoo.com organization: 1Department of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey – sequence: 6 givenname: Fad l surname: Vardar fullname: Vardar, Fad l email: dyilmazk@yahoo.com, dyilmazk@yahoo.com organization: 1Department of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey – sequence: 7 givenname: Kaan surname: Kavakli fullname: Kavakli, Kaan email: dyilmazk@yahoo.com, dyilmazk@yahoo.com organization: 1Department of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey |
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SubjectTerms | acute leukemias Adolescent Antiviral Agents - therapeutic use Child Child, Preschool children Female Humans Influenza A Virus, H1N1 Subtype - isolation & purification Influenza, Human - complications Influenza, Human - diagnosis Influenza, Human - drug therapy Leukemia, Myelomonocytic, Acute - complications Leukemia, Myelomonocytic, Acute - diagnosis Leukemia, Myelomonocytic, Acute - drug therapy Male oseltamivir pandemic influenza Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy vaccination |
Title | Experience of Pandemic Influenza with H1N1 in Children with Leukemia |
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