Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells

• Published in: Journal of cellular and molecular medicine Vol. 23; no. 7; pp. 4795 - 4807
• Main Authors: Cheng, Man, Yang, Liu, Dong, Zhiping, Wang, Mengying, Sun, Yan, Liu, Huan, Wang, Xuan, Sai, Na, Huang, Guowei, Zhang, Xumei
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2019; John Wiley and Sons Inc
• Subjects: Acids; Alzheimer's disease; Animals; Brain; Brain Injuries - complications; Brain Injuries - metabolism; Brain Injuries - pathology; Brain injury; Brain Ischemia - complications; Brain Ischemia - metabolism; Brain Ischemia - pathology; Carotid arteries; Cell death; Cell Line; Cerebral blood flow; Cytokines; Cytokines - metabolism; Dentate gyrus; Dipeptides - pharmacology; Experiments; Folic acid; Folic Acid Deficiency - immunology; Glucose - deficiency; Hippocampus; Hippocampus - metabolism; Hypoxia; Immune response; Infarction, Middle Cerebral Artery - complications; Inflammation; Inflammation - pathology; inflammatory; ischaemia‐reperfusion; Ischemia; Male; Mice; Microglia; Microglia - drug effects; Microglia - immunology; microglial; Neurons - drug effects; Neurons - pathology; Notch pathway; Notch1 protein; Nuclear transport; Original; Oxygen; Phenylglycine; Phosphorylation; Rats, Sprague-Dawley; Receptor, Notch1 - metabolism; Reperfusion; Signal Transduction - drug effects; Stroke; Studies; Transcription Factor RelA - metabolism; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumors; Vitamin B; Vitamin deficiency; China; Notch pathway; microglial; ischaemia-reperfusion; hippocampus; folic acid; inflammatory

Recent studies revealed that folic acid deficiency (FD) increased the likelihood of stroke and aggravated brain injury after focal cerebral ischaemia. The microglia‐mediated inflammatory response plays a crucial role in the complicated pathologies that lead to ischaemic brain injury. However, whethe...