Characterization of Salmonella‐Induced Filaments (Sifs) Reveals a Delayed Interaction Between Salmonella‐Containing Vacuoles and Late Endocytic Compartments

• Published in: Traffic (Copenhagen, Denmark) Vol. 2; no. 9; pp. 643 - 653
• Main Authors: Brumell, John H., Tang, Patrick, Mills, Scott D., Finlay, B. Brett
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.09.2001
• Subjects: Animals; Antigens, CD - metabolism; Bacterial Proteins; Biological Transport; Cathepsin D - metabolism; Cathepsin D - pharmacology; Cholesterol - metabolism; Endocytosis; endosome; Endosomes - metabolism; Genes, Dominant; Glycoproteins - metabolism; Green Fluorescent Proteins; GTP Phosphohydrolases - metabolism; HeLa Cells; Humans; Luminescent Proteins - metabolism; Lysosomal Membrane Proteins; lysosome; Macrophages - metabolism; Macrophages - microbiology; Membrane Glycoproteins - metabolism; Mice; microbial pathogenesis; Microscopy, Fluorescence; Models, Biological; Mutation; Protein Binding; Protein Structure, Tertiary; rab GTP-Binding Proteins - metabolism; rab7 GTP-Binding Proteins; Salmonella typhimurium - pathogenicity; Time Factors; Transfection; type III secretion

Salmonella typhimurium is a facultative intracellular pathogen that colonizes host cells throughout the course of infection. A unique feature of this pathogen is its ability to enter into (invade) epithelial cells and elongate the vacuole within which it resides into tubular structures called Salmon...