Mitophagy bridges DNA sensing with metabolic adaption to expand lung cancer stem‐like cells

• Published in: EMBO reports Vol. 24; no. 2; pp. e54006 - n/a
• Main Authors: Liu, Zhen, Shan, Shan, Yuan, Zixin, Wu, Fengying, Zheng, Ming, Wang, Ying, Gui, Jun, Xu, Wei, Wang, Chunhong, Ren, Tao, Wen, Zhenke
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.02.2023; Blackwell Publishing Ltd
• Subjects: Accumulation; AMP-Activated Protein Kinases - metabolism; AMPK; cancer stem‐like cell; Cell Line, Tumor; Chemoresistance; Chimeras; DNA, Mitochondrial - genetics; EMBO03; EMBO34; EMBO37; Hemostasis; Hemostatics; Humans; Hyperactivity; Life Sciences; LKB1 protein; Lung; Lung cancer; Lung Neoplasms - pathology; Lysosomes; Metabolic rate; Metabolism; Mitochondrial DNA; Mitophagy; Neoplastic Stem Cells - metabolism; Notch1; Notch1 protein; Phosphates; Phosphorylation; TLR9; TLR9 protein; Toll-Like Receptor 9 - metabolism; Toll-like receptors; Tumors; Xenografts; Xenotransplantation; TLR9; AMPK; mitophagy; Notch1; cancer stem‐like cell; cancer stem-like cell

While previous studies have identified cancer stem‐like cells (CSCs) as a crucial driver for chemoresistance and tumor recurrence, the underlying mechanisms for populating the CSC pool remain unclear. Here, we identify hypermitophagy as a feature of human lung CSCs, promoting metabolic adaption via...