Acute lymphoblastic leukemia with the phenotype of a putative B‐cell/T‐cell bipotential precursor

• Published in: American journal of hematology Vol. 77; no. 2; pp. 156 - 160
• Main Authors: Lau, Lee Gong, Tan, Lip Kun, Koay, Evelyn S.C., Ee, Melvin H.L., Tan, Suat Hoon, Liu, Te Chih
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2004; Wiley-Liss
• Subjects: acute lymphoblastic leukemia; Aged; Antigens, CD - analysis; Antigens, Neoplasm - analysis; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Bone Marrow - pathology; Fatal Outcome; Flow Cytometry; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics; Genes, Immunoglobulin - genetics; Hematologic and hematopoietic diseases; Humans; Immunophenotyping; In Situ Hybridization, Fluorescence; Leukemia, Biphenotypic, Acute - diagnosis; Leukemia, Biphenotypic, Acute - drug therapy; Leukemia, Biphenotypic, Acute - genetics; Leukemia, Biphenotypic, Acute - immunology; Leukemia, Biphenotypic, Acute - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leukemic Infiltration; lymphoid progenitor cell; Male; Medical sciences; Polymerase Chain Reaction; Skin - pathology; Lymphoid cell; Hematology; Immunophenotype; Acute; Stem cell; Precursor cell; Hematopoietic cell; Acute leukemia; Malignant hemopathy; acute lymphoblastic leukemia; immunophenotyping; Lymphoproliferative syndrome; T-Lymphocyte; Acute lymphocytic leukemia; lymphoid progenitor cell

Biphenotypic acute leukemias (BALs) are uncommon. Most are of myeloid‐B‐cell or myeloid‐T‐cell lineage. We report herein a 70‐year‐old man with an unusual acute leukemia where the blasts expressed both B‐ and T‐lymphoid markers. He presented to us with an enlarging cutaneous tumor. The presenting pe...