Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes

• Published in: Journal of autoimmunity Vol. 117; p. 102581
• Main Authors: Okamato, Yuko, Ghosh, Tusharkanti, Okamoto, Tsukasa, Schuyler, Ronald P., Seifert, Jennifer, Charry, Laura Lenis, Visser, Ashley, Feser, Marie, Fleischer, Chelsie, Pedrick, Chong, August, Justin, Moss, Laurakay, Bemis, Elizabeth A., Norris, Jill M., Kuhn, Kristine A., Demoruelle, M. Kristen, Deane, Kevin D., Ghosh, Debashis, Holers, V. Michael, Hsieh, Elena W.Y.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2021
• Subjects: Adult; Aged; Arthritis, Rheumatoid - etiology; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - pathology; Autoantibodies - immunology; Autoantigens - immunology; Biomarkers; Citrullination; Cytokines; Cytokines - metabolism; Disease Susceptibility; Female; Fluorescent Antibody Technique; Histone H3 citrullination; Histones - metabolism; Humans; Immunometabolism; Immunophenotyping; Inflammation Mediators - metabolism; Male; Middle Aged; Monocyte extracellular traps; Monocytes - immunology; Monocytes - metabolism; Protein-Arginine Deiminase Type 4 - metabolism; Rheumatoid arthritis; Toll-like receptor; Toll-Like Receptors - metabolism; Monocyte extracellular traps; Immunometabolism; Cytokines; Rheumatoid arthritis; Histone H3 citrullination; Toll-like receptor

The presence of anti-citrullinated protein/peptide antibodies (ACPA) and epitope spreading across the target autoantigens is a unique feature of rheumatoid arthritis (RA). ACPA are present in the peripheral blood for several years prior to the onset of arthritis and clinical classification of RA. AC...