Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin‐6 on colonic function in Sprague–Dawley rats

• Published in: Experimental physiology Vol. 101; no. 12; pp. 1477 - 1491
• Main Authors: Buckley, Maria M., O'Brien, Rebecca, Devlin, Michelle, Creed, Aisling A., Rae, Mark G., Hyland, Niall P., Quigley, Eamonn M. M., McKernan, Declan P., O'Malley, Dervla
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2016
• Subjects: Adolescent; Adult; Aged; Animals; Colon - drug effects; Colon - metabolism; colonic contractility; colonic secretion; Cytokines - metabolism; enteric neurons; Gastrointestinal Motility - drug effects; Humans; Interleukin-6 - metabolism; interleukin‐6; Irritable Bowel Syndrome - metabolism; leptin; Leptin - pharmacology; Male; Middle Aged; Neurons - drug effects; Pneumoviridae; Rats; Rats, Sprague-Dawley; Young Adult; enteric neurons; colonic contractility; leptin; colonic secretion; interleukin-6

New Findings What is the central question of this study? Does crosstalk exist between leptin and interleukin‐6 in colonic enteric neurons, and is this a contributory factor in gastrointestinal dysfunction associated with irritable bowel syndrome? What is the main finding and its importance? Leptin a...