Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates

• Published in: Journal of thrombosis and haemostasis Vol. 4; no. 2; pp. 392 - 397
• Main Authors: GRUBER, A., FERNÁNDEZ, J. A., BUSH, L., MARZEC, U., GRIFFIN, J. H., HANSON, S. R., DI CERA, E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.02.2006
• Subjects: Amino Acid Substitution; Animals; Anticoagulants - administration & dosage; Anticoagulants - pharmacology; anticoagulation; Hemostasis - drug effects; Humans; Infusions, Intravenous; Injections, Intravenous; Mutagenesis, Site-Directed; Papio; protein C; Protein C - metabolism; Recombinant Proteins - administration & dosage; Recombinant Proteins - genetics; Recombinant Proteins - pharmacology; Thrombin - administration & dosage; Thrombin - genetics; Thrombin - pharmacology; thrombomodulin

Anticoagulation with activated protein C (APC) reduces the mortality of severe sepsis. We investigated whether the circulating protein C (PC) pool could be utilized for sustained anticoagulation by endogenous APC. To generate APC without procoagulant effects, we administered the anticoagulant thromb...