Clinical outcomes of eradication of Helicobacter pylori in nonulcer dyspepsia in a population with a high prevalence of infection : Results of a 12-month randomized, double blind, placebo-controlled study
Ninety-one Helicobacter pylori-positive patients with nonulcer dyspepsia were randomized to receive either lansoprazole, amoxicillin, and clarithromycin or lansoprazole and placebo. A validated questionnaire assessed dyspeptic symptoms at baseline and at 3, 6, and 12 months. Endoscopies and biopsies...
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Published in | Digestive diseases and sciences Vol. 51; no. 1; pp. 89 - 98 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Heidelberg
Springer
2006
Springer Nature B.V |
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Abstract | Ninety-one Helicobacter pylori-positive patients with nonulcer dyspepsia were randomized to receive either lansoprazole, amoxicillin, and clarithromycin or lansoprazole and placebo. A validated questionnaire assessed dyspeptic symptoms at baseline and at 3, 6, and 12 months. Endoscopies and biopsies were performed at baseline and at 3 and 12 months. There was an overall trend, although not statistically significant, for a benefit of H. pylori eradication. Of the patients in the antibiotics group, 16 of 46 (35%) had symptomatic improvement, versus 9 of 43 (21%) in the control group (P = 0.164). In a secondary analysis, it was found that of the patients without endoscopic gastric erosions, 15 of 34 (44%) in the antibiotics group and 5 of 33 (15%) of controls had symptomatic improvement (P = 0.015). Helicobacter pylori eradication did not prove to be clinically beneficial, although a tendency to symptomatic benefit was detected. Further studies are necessary to confirm the implications of endoscopic gastric erosions in these patients. |
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AbstractList | Ninety-one Helicobacter pylori-positive patients with nonulcer dyspepsia were randomized to receive either lansoprazole, amoxicillin, and clarithromycin or lansoprazole and placebo. A validated questionnaire assessed dyspeptic symptoms at baseline and at 3, 6, and 12 months. Endoscopies and biopsies were performed at baseline and at 3 and 12 months. There was an overall trend, although not statistically significant, for a benefit of H. pylori eradication. Of the patients in the antibiotics group, 16 of 46 (35%) had symptomatic improvement, versus 9 of 43 (21%) in the control group (P = 0.164). In a secondary analysis, it was found that of the patients without endoscopic gastric erosions, 15 of 34 (44%) in the antibiotics group and 5 of 33 (15%) of controls had symptomatic improvement (P = 0.015). Helicobacter pylori eradication did not prove to be clinically beneficial, although a tendency to symptomatic benefit was detected. Further studies are necessary to confirm the implications of endoscopic gastric erosions in these patients. |
Author | THEIL, Alexandro L OTT, Eduardo A SANDER, Guilherme B WORTMANN, André C FRITSCHER, Leandro G PROLLA, Joao C EDELWEISS, Maria I. A BARROS, Sérgio G. S UCHOA, Diego M POLANCZYK, Carisi A FRANCESCONI, Carlos F CARTELL, André RIVERO, Luis F MAZZOLENI, Luiz E |
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Keywords | Helicohacter pylori Prognosis Prevalence Spirillales Dyspepsia Spirillaceae Metabolic diseases Eradication Gastrointestinal Epidemiology Gastritis Infection Helicobacter pylori Gastroenterology Double blind study Digestive diseases Bacteria Endoscopy Gastric disease |
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SubjectTerms | 2-Pyridinylmethylsulfinylbenzimidazoles Adolescent Adult Aged Amoxicillin - therapeutic use Anti-Infective Agents - therapeutic use Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biopsy Brazil - epidemiology Clarithromycin - therapeutic use Double-Blind Method Drug Therapy, Combination Dyspepsia - drug therapy Dyspepsia - etiology Dyspepsia - pathology Endoscopy, Gastrointestinal Feeding. Feeding behavior Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Gastric Mucosa - microbiology Gastric Mucosa - pathology Gastritis - complications Gastritis - drug therapy Gastritis - microbiology Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - drug therapy Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - isolation & purification Human bacterial diseases Humans Infectious diseases Lansoprazole Male Medical sciences Middle Aged Omeprazole - analogs & derivatives Omeprazole - therapeutic use Other diseases. Semiology Prevalence Prospective Studies Proton Pump Inhibitors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems |
Title | Clinical outcomes of eradication of Helicobacter pylori in nonulcer dyspepsia in a population with a high prevalence of infection : Results of a 12-month randomized, double blind, placebo-controlled study |
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