Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission

• Published in: AIDS (London) Vol. 28; no. 18; pp. 2739 - 2749
• Main Authors: DAVIS, Nicole L, MILLER, William C, JAMIESON, Denise J, VAN DER HORST, Charles, HUDGENS, Michael G, CHASELA, Charles S, SICHALI, Dorothy, KAYIRA, Dumbani, NELSON, Julie A. E, STRINGER, Jeffrey S. A, ELLINGTON, Sascha R, KOURTIS, Athena P
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 28.11.2014
• Subjects: Adolescent; Adult; Anti-Retroviral Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Breast Feeding; Cohort Studies; Disease Transmission, Infectious - prevention & control; Female; HIV Infections - drug therapy; HIV Infections - prevention & control; HIV Infections - transmission; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infant; Infant, Newborn; Infectious diseases; Lentivirus; Male; Medical sciences; Medication Adherence; Middle Aged; Milk, Human - virology; Pharmacology. Drug treatments; Postpartum Period; Pregnancy; Prospective Studies; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Young Adult; Antiretroviral agent; HIV-1 virus; Maternal diseases; prevention of mother-to-child HIV transmission; Prevention; Antiviral; HIV transmission; Immunopathology; adherence; Retroviridae; AIDS; Breast feeding; Puerperium; Immune deficiency; Lentivirus; Adhesion; Infection; Virus; antiretroviral; Viral disease; Human milk; Vertical transmission; Human immunodeficiency virus; breastfeeding; Breast milk

Estimate association between postpartum antiretroviral adherence and breast milk HIV-1 transmission. Prospective cohort study. Mother-infant pairs were randomized after delivery to immediately begin receiving 28 weeks of either triple maternal antiretrovirals (zidovudine, lamivudine, and either nevi...