Clinical applications of maternal plasma fetal DNA analysis: translating the fruits of 15 years of research

• Published in: Clinical chemistry and laboratory medicine Vol. 51; no. 1; pp. 197 - 204
• Main Authors: Kwun Chiu, Rossa Wai, Dennis Lo, Yuk Ming
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.01.2013; Walter De Gruyter & Company
• Subjects: Amniocentesis; Aneuploidy; Blood groups; cell-free fetal DNA; Deoxyribonucleic acid; Diagnosis; DNA; DNA - blood; DNA - genetics; DNA - history; Down syndrome; Fetuses; Genetic disorders; Genomes; Genotyping; History, 20th Century; History, 21st Century; Humans; maternal plasma DNA; next-generation sequencing; non-invasive prenatal diagnosis; Plasma; Prenatal diagnosis; Prenatal Diagnosis - history; Prenatal Diagnosis - methods; Research - history; Sampling; Villus

The collection of fetal genetic materials is required for the prenatal diagnosis of fetal genetic diseases. The conventional methods for sampling fetal genetic materials, such as amniocentesis and chorionic villus sampling, are invasive in nature and are associated with a risk of fetal miscarriage....