Comparison of results and age-related changes in establishing reference intervals for CEA, AFP, CA125, and CA199 using four indirect methods

•The reference intervals calculated using RefineR, Kosmic, TMC, and non-parametric methods are similar.•TMC algorithm is more robust, demonstrates a high pass rate among the four methods and has the ability to automatically isolate outliers.•The reference intervals of CA125 and CA199 showed signific...

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Published inPractical laboratory medicine Vol. 38; p. e00353
Main Authors Chen, Juping, Fan, Lina, Yang, Zheng, Yang, Dagan
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 01.01.2024
Online AccessGet full text
ISSN2352-5517
2352-5517
DOI10.1016/j.plabm.2023.e00353

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Summary:•The reference intervals calculated using RefineR, Kosmic, TMC, and non-parametric methods are similar.•TMC algorithm is more robust, demonstrates a high pass rate among the four methods and has the ability to automatically isolate outliers.•The reference intervals of CA125 and CA199 showed significant differences between age and sex.
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ISSN:2352-5517
2352-5517
DOI:10.1016/j.plabm.2023.e00353