Acetylation of BLM protein regulates its function in response to DNA damage

• Published in: RSC advances Vol. 7; no. 87; pp. 5531 - 5538
• Main Authors: Wang, Yankun, Luo, Jianyuan
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 01.01.2017
• Subjects: Acetylation; Chromatin; Deoxyribonucleic acid; DNA; DNA damage; DNA helicases; DNA repair; etoposide; genes; genomics; hydroxyurea; Lysine; Mutation; neoplasms; phenotype

Bloom syndrome is an autosomal recessive disease with phenotypes of cancer predisposition and premature aging caused by mutations of the blm gene. BLM belongs to the RecQ DNA helicase family and functions in maintaining genomic stability. In this study, we found that several lysine residues of BLM w...