Administration of Lactobacillus reuteri Combined with Clostridium butyricum Attenuates Cisplatin-Induced Renal Damage by Gut Microbiota Reconstitution, Increasing Butyric Acid Production, and Suppressing Renal Inflammation

• Published in: Nutrients Vol. 13; no. 8; p. 2792
• Main Authors: Hsiao, Yu-Ping, Chen, Hsiao-Ling, Tsai, Jen-Ning, Lin, Meei-Yn, Liao, Jiunn-Wang, Wei, Meng-Syuan, Ko, Jiunn-Liang, Ou, Chu-Chyn
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 15.08.2021; MDPI
• Subjects: apoptosis; Bifidobacterium; blood; butyric acid; Cancer therapies; Chemotherapy; cisplatin; Clostridium butyricum; collagen; dysbiosis; endotoxins; Enterobacteriaceae; epithelium; Feces; fibronectins; fibrosis; Gut microbiota; Inflammation; intestinal microorganisms; intestines; Lactobacillus reuteri; microbiome; Microbiota; Mucositis; nephrotoxicity; oxidative stress; Probiotics; protective effect; Proteins; renoprotective effect; Ruminococcaceae; sulfates; Tumors; Minneapolis Minnesota; United Kingdom > UK; United States > US; Taiwan

Cisplatin-induced nephrotoxicity is associated with gut microbiota disturbance. The present study aimed to investigate whether supplementation of Lactobacillus reuteri and Clostridium butyricum (LCs) had a protective effect on cisplatin-induced nephrotoxicity through reconstruction of gut microbiota...