Arterial dysgenesis and limb defects: Clinical and experimental examples

Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitio...

Full description

Saved in:
Bibliographic Details
Published inReproductive toxicology (Elmsford, N.Y.) Vol. 70; pp. 21 - 29
Main Authors Vargesson, Neil, Hootnick, David R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2017
Subjects
Animals
Blood Vessels - abnormalities
Blood Vessels - embryology
Clubfoot
Extremities - blood supply
Extremities - embryology
Female
Holt-Oram Syndrome
Human embryo
Humans
Limb Deformities, Congenital - etiology
Mifepristol
PFFD (proximal femoral focal deficiency)
Pregnancy
Teratogens - toxicity
Thalidomide
Vascular disruption
Vascular transition
Vertebrate embryo
Vertical talus
Vascular disruption
Holt-Oram Syndrome
Vascular transition
Vertical talus
Vertebrate embryo
PFFD (proximal femoral focal deficiency)
Thalidomide
Mifepristol
Human embryo
Clubfoot
Online AccessGet full text

Cover

More Information
Summary:Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitioning and from events such as amniocentesis, uterine constriction, and through teratogen exposure. We use several clinical and experimental examples and highlight the need to understand more about the role the vascular system plays in the molecular mechanisms underpinning normal limb development.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2016.10.005