Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation

• Published in: Nucleic acids research Vol. 49; no. 22; pp. 12706 - 12715
• Main Authors: Song, Yanhua, Hou, Gaopeng, Diep, Jonathan, Ooi, Yaw Shin, Akopyants, Natalia S, Beverley, Stephen M, Carette, Jan E, Greenberg, Harry B, Ding, Siyuan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 16.12.2021
• Subjects: CRISPR-Cas Systems; Endogenous Retroviruses; Gene regulation, Chromatin and Epigenetics; Gene Silencing; HeLa Cells; Histone Code; Homeodomain Proteins - metabolism; Homeodomain Proteins - physiology; HT29 Cells; Humans; Immunity, Innate - genetics; Tumor Suppressor Proteins - metabolism; Tumor Suppressor Proteins - physiology

Abstract Endogenous retroviruses (ERVs) are subject to transcriptional repression in adult tissues, in part to prevent autoimmune responses. However, little is known about the epigenetic silencing of ERV expression. Here, we describe a new role for inhibitor of growth family member 3 (ING3), to add...