Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 295; no. 2; pp. R463 - R471
• Main Authors: Sahr, Allison E, Sindelar, Dana K, Alexander-Chacko, Jesline T, Eastwood, Brian J, Mitch, Charles H, Statnick, Michael A
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2008
• Subjects: Animals; Appetite Regulation - drug effects; Behavior, Animal - drug effects; Body weight; Cyclohexanes - pharmacology; Diet; Dopamine - metabolism; Eating - drug effects; Food; Food Preferences; Male; Microdialysis; Narcotic Antagonists - pharmacology; Neurons - drug effects; Neurons - metabolism; Neurotransmitters; Nucleus Accumbens - cytology; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Obesity; Piperidines - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Opioid - metabolism; Reinforcement (Psychology); Rodents; Time Factors; Weight

Lilly Research Laboratories, Indianapolis, Indiana Submitted 5 June 2007 ; accepted in final form 3 June 2008 An analog of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine series (LY255582 ) exhibits high in vitro binding affinity and antagonist potency for the µ-, -, and -opioid receptors. In v...