Labelling and determination of the energy in reactive intermediates in solution enabled by energy-dependent reaction selectivity

• Published in: Nature chemistry Vol. 10; no. 2; pp. 237 - 241
• Main Authors: Kurouchi, Hiroaki, Singleton, Daniel A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2018; Nature Publishing Group
• Subjects: 639/638/403/934; 639/638/440/950; Analytical Chemistry; Balancing; Biochemistry; Chemistry; Chemistry/Food Science; Cleavage; Energy; Inorganic Chemistry; Intermediates; Isotope effect; Labeling; Organic Chemistry; Physical Chemistry; Selectivity

Any long-lived chemical structure in solution is subject to statistical energy equilibration, so the history of any specific structure does not affect its subsequent reactions. This is not true for very short-lived intermediates because energy equilibration takes time. Here, this idea is applied to...