Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting

• Published in: Learning & memory (Cold Spring Harbor, N.Y.) Vol. 31; no. 7; p. a053911
• Main Authors: Miles, Jesse T., Mullins, Ginger L., Mizumori, Sheri J. Y.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.07.2024
• Subjects: Accuracy; Animals; Behavior; Choice Behavior - physiology; Choice learning; Decision making; Decision Making - physiology; Exploratory behavior; Flexibility; Learning - physiology; Male; Mental task performance; Prefrontal cortex; Prefrontal Cortex - physiology; Rats; Rats, Long-Evans; Research Paper; Reward; Spatial discrimination learning

Flexible decision-making requires a balance between exploring features of an environment and exploiting prior knowledge. Behavioral flexibility is typically measured by how long it takes subjects to consistently make accurate choices after reward contingencies switch or task rules change. This measu...