Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2

• Published in: The American journal of medicine Vol. 113; no. 3; pp. 194 - 199
• Main Authors: Frémeaux-Bacchi, Véronique, Guinnepain, Marie-Thérèse, Cacoub, Patrice, Dragon-Durey, Marie-Agnès, Mouthon, Luc, Blouin, Jacques, Cherin, Patrick, Laurent, Jérome, Piette, Jean-Charles, Fridman, Wolf-H, Weiss, Laurence, Kazatchkine, Michel O
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.08.2002; Elsevier; Elsevier Sequoia S.A
• Subjects: Acquired angioedema; Age Distribution; Aged; Allergic diseases; Angioedema - diagnosis; Angioedema - epidemiology; Angioedema - immunology; Antibodies, Anti-Idiotypic - analysis; Antibodies, Anti-Idiotypic - immunology; Biological and medical sciences; Blotting, Western; C1 inhibitor; Cardiovascular disease; Cohort Studies; Comorbidity; Complement; Complement C1 Inactivator Proteins - analysis; Complement C1 Inactivator Proteins - immunology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Immunoglobulin A - analysis; Immunoglobulin G - analysis; Immunoglobulin M - analysis; Immunopathology; Lymphoproliferation; Lymphoproliferative Disorders - epidemiology; Lymphoproliferative Disorders - immunology; Male; Medical diagnosis; Medical research; Medical sciences; Middle Aged; Monoclonal gammopathy; Other localizations; Paraproteinemias - diagnosis; Paraproteinemias - epidemiology; Prevalence; Relapsing polychondritis; Risk Assessment; Sex Distribution; France; Europe; Acquired angioedema; C1 inhibitor; Monoclonal gammopathy; Complement; Lymphoproliferation; Relapsing polychondritis; Human; Immunopathology; Allergy; Prevalence; Antibody; Angioedema; Monoclonal immunoglobulinemia; Exploration; Epidemiology; Concomitant disease; Angioneurotic edema; Diagnosis; Public health

Acquired angioedema type 1 is characterized by a C1 inhibitor deficiency in patients with lymphoproliferative disorders, whereas acquired angioedema type 2 is characterized by anti-C1 inhibitor antibodies, and has not been thought to be associated with lymphoproliferative disease. We studied the cli...