Prevalence of suicide attempt in individuals with major depressive disorder: a meta-analysis of observational surveys

Suicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals wi...

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Published inPsychological medicine Vol. 49; no. 10; pp. 1691 - 1704
Main Authors Dong, Min, Zeng, Liang-Nan, Lu, Li, Li, Xiao-Hong, Ungvari, Gabor S., Ng, Chee H., Chow, Ines H. I., Zhang, Ling, Zhou, Yuan, Xiang, Yu-Tao
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.07.2019
Subjects
Confidence intervals
Depressive personality disorders
Epidemiology
Medical screening
Mental depression
Mental disorders
Meta-analysis
Observational studies
Original Articles
Prevalence
Random effects
Suicide
Suicides & suicide attempts
Systematic review
Beijing China
China
meta-analysis
suicide attempt
Major depressive disorder
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Abstract Suicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals with MDD. A systematic literature search was conducted in PubMed, Embase, PsycINFO, Web of Science and Cochrane Library from their commencement date until 27 December 2017. Original studies containing data on prevalence of SA in individuals with MDD were analyzed. In all, 65 studies with a total of 27 340 individuals with MDD were included. Using the random effects model, the pooled lifetime prevalence of SA was 31% [95% confidence interval (CI) 27-34%], 1-year prevalence was 8% (95% CI 3-14%) and 1-month prevalence was 24% (95% CI 15-34%). Subgroup analyses revealed that the lifetime prevalence of SA was significantly associated with the patient setting, study region and income level, while the 1-month prevalence of SA was associated with only the patient setting. This meta-analysis confirmed that SA was common in individuals with MDD across the world. Careful screening and appropriate interventions should be implemented for SA in the MDD population.
AbstractList Suicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals with MDD.BACKGROUNDSuicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals with MDD.A systematic literature search was conducted in PubMed, Embase, PsycINFO, Web of Science and Cochrane Library from their commencement date until 27 December 2017. Original studies containing data on prevalence of SA in individuals with MDD were analyzed.METHODSA systematic literature search was conducted in PubMed, Embase, PsycINFO, Web of Science and Cochrane Library from their commencement date until 27 December 2017. Original studies containing data on prevalence of SA in individuals with MDD were analyzed.In all, 65 studies with a total of 27 340 individuals with MDD were included. Using the random effects model, the pooled lifetime prevalence of SA was 31% [95% confidence interval (CI) 27-34%], 1-year prevalence was 8% (95% CI 3-14%) and 1-month prevalence was 24% (95% CI 15-34%). Subgroup analyses revealed that the lifetime prevalence of SA was significantly associated with the patient setting, study region and income level, while the 1-month prevalence of SA was associated with only the patient setting.RESULTSIn all, 65 studies with a total of 27 340 individuals with MDD were included. Using the random effects model, the pooled lifetime prevalence of SA was 31% [95% confidence interval (CI) 27-34%], 1-year prevalence was 8% (95% CI 3-14%) and 1-month prevalence was 24% (95% CI 15-34%). Subgroup analyses revealed that the lifetime prevalence of SA was significantly associated with the patient setting, study region and income level, while the 1-month prevalence of SA was associated with only the patient setting.This meta-analysis confirmed that SA was common in individuals with MDD across the world. Careful screening and appropriate interventions should be implemented for SA in the MDD population.CONCLUSIONThis meta-analysis confirmed that SA was common in individuals with MDD across the world. Careful screening and appropriate interventions should be implemented for SA in the MDD population.
Suicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals with MDD. A systematic literature search was conducted in PubMed, Embase, PsycINFO, Web of Science and Cochrane Library from their commencement date until 27 December 2017. Original studies containing data on prevalence of SA in individuals with MDD were analyzed. In all, 65 studies with a total of 27 340 individuals with MDD were included. Using the random effects model, the pooled lifetime prevalence of SA was 31% [95% confidence interval (CI) 27-34%], 1-year prevalence was 8% (95% CI 3-14%) and 1-month prevalence was 24% (95% CI 15-34%). Subgroup analyses revealed that the lifetime prevalence of SA was significantly associated with the patient setting, study region and income level, while the 1-month prevalence of SA was associated with only the patient setting. This meta-analysis confirmed that SA was common in individuals with MDD across the world. Careful screening and appropriate interventions should be implemented for SA in the MDD population.
BackgroundSuicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals with MDD.MethodsA systematic literature search was conducted in PubMed, Embase, PsycINFO, Web of Science and Cochrane Library from their commencement date until 27 December 2017. Original studies containing data on prevalence of SA in individuals with MDD were analyzed.ResultsIn all, 65 studies with a total of 27 340 individuals with MDD were included. Using the random effects model, the pooled lifetime prevalence of SA was 31% [95% confidence interval (CI) 27–34%], 1-year prevalence was 8% (95% CI 3–14%) and 1-month prevalence was 24% (95% CI 15–34%). Subgroup analyses revealed that the lifetime prevalence of SA was significantly associated with the patient setting, study region and income level, while the 1-month prevalence of SA was associated with only the patient setting.ConclusionThis meta-analysis confirmed that SA was common in individuals with MDD across the world. Careful screening and appropriate interventions should be implemented for SA in the MDD population.
Author Zeng, Liang-Nan
Dong, Min
Chow, Ines H. I.
Xiang, Yu-Tao
Li, Xiao-Hong
Ungvari, Gabor S.
Zhang, Ling
Zhou, Yuan
Ng, Chee H.
Lu, Li
Author_xml – sequence: 1
  givenname: Min
  surname: Dong
  fullname: Dong, Min
  organization: 1Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
– sequence: 2
  givenname: Liang-Nan
  surname: Zeng
  fullname: Zeng, Liang-Nan
  organization: 2Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China
– sequence: 3
  givenname: Li
  surname: Lu
  fullname: Lu, Li
  organization: 1Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
– sequence: 4
  givenname: Xiao-Hong
  surname: Li
  fullname: Li, Xiao-Hong
  organization: 3The National Clinical Research Center for Mental Disorders, China & Center of Depression, Beijing Institute for Brain Disorders & Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China
– sequence: 5
  givenname: Gabor S.
  surname: Ungvari
  fullname: Ungvari, Gabor S.
  organization: 4University of Notre Dame Australia/Marian Centre, Perth, Australia
– sequence: 6
  givenname: Chee H.
  surname: Ng
  fullname: Ng, Chee H.
  organization: 5Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
– sequence: 7
  givenname: Ines H. I.
  surname: Chow
  fullname: Chow, Ines H. I.
  organization: 1Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
– sequence: 8
  givenname: Ling
  surname: Zhang
  fullname: Zhang, Ling
  organization: 6Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University & Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
– sequence: 9
  givenname: Yuan
  surname: Zhou
  fullname: Zhou, Yuan
  organization: 7CAS Key Laboratory of Behavioral Science & Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
– sequence: 10
  givenname: Yu-Tao
  surname: Xiang
  fullname: Xiang, Yu-Tao
  email: xyutly@gmail.com
  organization: 1Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30178722$$D View this record in MEDLINE/PubMed
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Snippet Suicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across...
BackgroundSuicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence...
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SubjectTerms Confidence intervals
Depressive personality disorders
Epidemiology
Medical screening
Mental depression
Mental disorders
Meta-analysis
Observational studies
Original Articles
Prevalence
Random effects
Suicide
Suicides & suicide attempts
Systematic review
Title Prevalence of suicide attempt in individuals with major depressive disorder: a meta-analysis of observational surveys
URI https://www.cambridge.org/core/product/identifier/S0033291718002301/type/journal_article
https://www.ncbi.nlm.nih.gov/pubmed/30178722
https://www.proquest.com/docview/2280496863
https://www.proquest.com/docview/2099433304
Volume 49
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