Conserved Cysteines in the Type 1 Deiodinase Selenoprotein Are Not Essential for Catalytic Activity

• Published in: The Journal of biological chemistry Vol. 273; no. 39; pp. 25230 - 25236
• Main Authors: Croteau, Walburga, Bodwell, Jack E., Richardson, Jan M., Germain, Donald L. St
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.09.1998; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Catalysis; COS Cells; Cysteine - metabolism; Iodide Peroxidase - chemistry; Iodide Peroxidase - metabolism; Kinetics; Mutation; Proteins - chemistry; Proteins - metabolism; Rats; Selenoproteins

The iodothyronine deiodinases are a family of oxidoreductases that catalyze the removal of iodide from thyroid hormones. Each of the three isoforms contain selenocysteine at its active site and several cysteine residues that may be important for catalytic activity. Of particular interest in the type...