Cerebral metabolic and cognitive studies in dementia with frontal lobe behavioral features

• Published in: Journal of psychiatric research Vol. 24; no. 2; pp. 97 - 109
• Main Authors: Kumar, Anand, Schapiro, Mark B., Haxby, James V., Grady, Cheryl L., Friedland, Robert P.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1990; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - psychology; Biological and medical sciences; Blood Glucose - metabolism; Brain - diagnostic imaging; Deoxyglucose - analogs & derivatives; Deoxyglucose - metabolism; Energy Metabolism - physiology; Female; Fluorodeoxyglucose F18; Frontal Lobe - diagnostic imaging; Humans; Intellectual deficiency; Male; Medical sciences; Neuropsychological Tests; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Tomography, Emission-Computed; Human; Radionuclide study; Brain; Nervous system diseases; Senescence; Alzheimer disease; Cerebral hemisphere syndrome; Glucose; Metabolism; Screening; Frontal lobe syndrome; Positron emission tomography; Elderly; Positron

Three subjects with dementia of the Alzheimer type (DAT) with frontal lobe features of behavioral disinhibition were studied using positron emission tomography with [18F]2-fluoro-2-deoxy-D-glucose (18 FDG) and standardized neuropsychological tests. The three subjects showed significant decrements (...